Although nebulized liposomal amphotericin B (NLAB) is being used in invasive pulmonary aspergillosis (IPA) prophylaxis, no clinical trial has shown its efficacy as a therapeutic strategy. NAIFI is the inaugural randomized, controlled clinical trial designed to examine the safety and effectiveness of NLAB (dosage: 25 mg in 6 mL, three times per week for 6 weeks) against a placebo, in the auxiliary treatment of IPA. Throughout the three-year clinical trial, thirteen patients (six NLAB, seven placebo) were included, with 61% being onco-hematological with less than 100 neutrophils/μL. There were no significant differences noted in their pre- and post-nebulization results of forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and oxygen saturation between the groups. Neither bronchospasm nor serum amphotericin B levels were reported in any patients given NLAB. ¹⁸F-Fluorodeoxyglucose positron emission tomography (FDG-PET-TC) was carried out at the baseline and after 6 weeks. A notable decrease in median SUV (standardized uptake value) was observed in NLAB patients after 6 weeks (−3.6 vs. −0.95, p: 0.039, one tail). Furthermore, a reduction in serum substance galactomannan and beta-D-Glucan was identified within NLAB recipients. NLAB is well tolerated and safe for patients with IPA. Encouraging indirect efficacy data have been derived from image monitoring or biomarkers. However, further studies involving more patients are necessary.

Daily clinical practice is an important source of stress and emotional exhaustion. In the health field, patients could experience a significant number of emotional reactions. There are high levels of anxiety in patients referred for medical imaging, and these levels are even higher in patients undergoing complicated diagnostic procedures. All this shows the need to understand that anxiety must be diagnosed and treated. This situation forces radiologist to develop emotional and social skills to resolve difficulties that may arise in the communicative act. In the patient-radiologist interaction, many elements have been analysed, being communication and communicative skills one of the most important elements. The objective is to present an emotional management tool, the U-technique. It consists of four movements: sympathize, empathize, feel the antidote emotion and spread the antidote emotion in order that the health professionals recognize their emotional state in each moment of the relationship with the patient.

El nacimiento de un hijo/a con discapacidad es un acontecimiento que genera estrés, depresión y un fuerte impacto emocional en padres y madres, por ello el objetivo de este trabajo es investigar este aspecto. Método: Han participado 59 familias con hijos/as con diagnóstico discapacidad de la Comunidad de Madrid, siendo el 71.2% mujeres. Se usó un cuestionario elaborado ad hoc, la Escala de Estrés Percibido, el Inventario de Depresión Beck-II, la Escala de Resiliencia de Connor y Davidson (CD-RISC) y la Escala de Confianza Familiar (Con-Fam). Resultados: Las familias han manifestado estrés percibido, así como síntomas de depresión leve, sin embargo, los niveles de resiliencias son altos. En cuanto a la confianza familiar también ha sido adecuada. El análisis de las diferencias estadísticamente significativas muestra como el tipo de discapacidad, el número de hijos, la búsqueda de ayuda, la estructura familiar y las distintas emociones sentidas en distintos momentos temporales mostraron interesantes resultados. Conclusiones: Tener un hijo/a con discapacidad provoca en la familia respuestas de estrés y depresión, sin embargo, a pesar de este impacto las familias sienten capacidad de afrontamiento y confianza ante el cuidado del hijo/a.