Dr. Chunbo He is a leading figure in anti-tumor research, dedicated to identifying innovative therapeutic targets and improving treatment strategies for malignant tumors. His academic foundation was established under Professor Cheng Wang, where he explored the Hippo/YAP signaling pathway and its implications for cancers such as ovarian and cervical cancer. His esteemed publications span top journals, highlighting his contributions to cancer biology. As a doctoral student and postdoctoral fellow, Dr. He collaborated with prominent scholars to examine how targeted nutrient metabolism can enhance the tumor immune microenvironment, improving the efficacy of immunotherapies. His notable findings include: 1. Discovering that vitamin B6 metabolism fosters pancreatic tumor growth while hindering NK cell-mediated immunity, suggesting a new therapeutic direction for pancreatic cancer. 2. Investigating the regulatory interplay between the Hippo/YAP pathway and HPV, pointing to YAP as a potential target in cervical cancer treatment. 3. Defining the Hippo/YAP pathway's roles in ovarian function and cancer development, advocating for its targeting in both ovarian cancer and certain infertility cases.
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, USA
University Educator/Researcher
OKLAHOMA UNIVERSITY HEALTH SCIENCE CENTER
01 Sep 2023 - present
Post Doctoral Researcher
OKLAHOMA UNIVERSITY HEALTH SCIENCE CENTER
01 May 2022 - 01 Mar 2025
Graduate Student or Post Graduate
UNIVERSITY OF NEBRASKA MEDICAL CENTER
01 Aug 2018 - 01 May 2022