Herein, a conductivity method was engaged to explore the effects of a fluoroquinolone drug, namely ciprofloxacin hydrochloride (CFH)/CFH + polyols (organic compounds with multiple hydroxyl groups (glucose and fructose)), on the aggregation phenomenon of sodium dodecyl sulfate (SDS) at different temperatures (298.15–318.15 K) while maintaining a gap of 5 K. In this study, the critical micelle concentration (cmc) of the SDS/SDS + CFH mixture in water and polyols media was determined from plots of the specific conductivity versus the concentration of SDS to gain knowledge of the effects of CFH/CFH + polyols on the micelle formation behavior of SDS. The cmc value of the surfactant decreases in the presence of CFH in an aqueous medium; thus, CFH favors the micellization of SDS. The cmc values of SDS and the SDS + CFH mixture were enhanced in polyols media. The cmc values of SDS/SDS + CFH show a U-shaped behavior with temperature. The counterion dissociation (α) of the pure surfactant is higher in the presence of the drug and is further enhanced through an increase in the CFH concentration in water/polyols media. Different thermodynamic parameters, such as the Gibbs free energy of micellization , standard enthalpy , entropy , different transfer energies and enthalpy–entropy compensation parameters of micellization were determined and illustrated in detail to compare these parameters between the pure SDS and SDS + CFH mixture in polyols media. The negative values of for the SDS/SDS + CFH mixture in all cases indicate spontaneous micelle formation. The and values indicate the presence of both hydrophobic and electrostatic interactions amongst the studied components.

Interaction of moxifloxacin hydrochloride (MFH) with tetradecyltrimethylammonium bromide (TTAB) along with Triton X-100 (TX-100) under different experimental conditions has been carried out using multiple physico-chemical techniques. The micellar parameters like critical micelle concentration (cmc), counter ion binding (β), thermodynamic parameters such as , , and etc. associated with the drug-TTAB interaction have been determined. The changes of the values of cmc of TTAB by the addition of drug indicate the existence of TTAB-MFH interaction. The cmc values of drug-TTAB systems were found to be dependent on the variation of temperature, salt and alcohol concentrations. In all the cases the negative values of indicated the spontaneous micelle formation of drug-TTAB system. The values of and reveal the existence of hydrophobic and electrostatic interactions between drug and TTAB. The CP values of TX-100 in water were increased in the presence of MFH. The values of of drug-TX-100 mixed system are found to be positive which indicates the clouding process is nonspontaneous in nature. The binding constant (K_b) value for MFH-TX-100 system was found to be temperature dependent and the binding interaction between MFH and TX-100 is mainly due to hydrogen bonding.