Polypharmacy, a common condition among the older population, is associated with adverse outcomes, including higher mortality, falls and hospitalization rates, adverse drug reactions, drug–drug interactions, medication nonadherence, and consequently increased healthcare costs. Background/Objectives: This study aims to explore the prevalence of polypharmacy and its associated factors among older adults across 27 European countries and Israel. Methods: In this cross-sectional analysis, we used data from participants aged 65 years or older from Wave 9 of the Survey of Health, Aging, and Retirement in Europe (SHARE) database. The variables studied were classified into the following categories: sociodemographic, behavioral factors, physical functioning, physical health, mental health, and living conditions. Results: Our results showed an overall prevalence of polypharmacy of 36.2%, ranging from 25.0 to 51.8%. Slovenia, Greece, and Switzerland were the countries with the lowest prevalence, whereas Portugal, Israel, and Poland were the countries where the prevalence of polypharmacy was the highest. Polypharmacy was shown to be associated with variables from all categories. Conclusions: Polypharmacy is a highly prevalent condition in the older population. Identification of variables associated with polypharmacy, such as those identified in this study, is important to identify and monitor older groups, which are most vulnerable to polypharmacy. Interventions designed to reduce polypharmacy should consider these associations.

Background: Digital health technologies (DHTs) are transformative solutions for health care challenges; however, sustaining long-term adherence remains a significant barrier, limiting their effectiveness. Objective: This systematic review aims to identify and categorize factors influencing adherence to DHTs and to identify theoretical foundations used to predict it. Methods: This review was conducted according to the PICO (population, intervention, comparison, outcome) strategy and followed the Cochrane Handbook and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines. The protocol was prospectively registered on PROSPERO (CRD42024628168). Literature searches were performed in December 2024 in PubMed, PsycINFO, Scopus, and IEEE Xplore for studies published between 2019 and 2024 in English, Portuguese, or Spanish. Studies were eligible if they investigated factors influencing adherence to DHTs or theoretical foundations and tools predicting adherence. Nonpeer-reviewed studies, study protocols, and studies that did not explicitly report adherence outcomes were excluded. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Tools. Data were synthesized narratively through inductive thematic analysis, with factors influencing adherence extracted and categorized. Results: In total, 61 studies were included, mostly quantitative and conducted in Europe and North America. The populations were mainly patients with medical conditions, and most studies focused on mobile health apps. Study quality was moderate to high. The findings highlight a complex and multifaceted range of factors influencing adherence, which were categorized into four key domains: (1) personal factors (sociodemographic characteristics, health status, user characteristics, and personal beliefs and perceptions), (2) technology and intervention content factors (infrastructure and accessibility, user experience and performance, and content and features of the intervention), (3) social and support system factors (family and informal support and health care professional support), and (4) contextual factors. Among the theoretical foundations identified, the Unified Theory of Acceptance and Use of Technology (UTAUT) emerged as the most frequently applied. Conclusions: The findings highlight the need for integrative, health-specific models that combine behavioral, technological, and clinical aspects. Future research should focus on developing standardized adherence metrics and exploring the interactions between these factors to improve predictive models. However, the evidence base is limited by heterogeneity in study designs and adherence definitions, potential publication, and language bias.

Digital therapeutics (DTx) are transforming healthcare delivery through personalised, evidence-based interventions that offer a cost-effective approach to health management. However, their widespread adoption faces significant barriers including privacy concerns, usability issues, and integration challenges within healthcare systems. This review assesses the current evidence on DTx, with a particular focus on the role of co-creation in enhancing design and usability. A narrative review was conducted to identify studies exploring co-creation in DTx development. Three studies were selected for in-depth analysis, demonstrating that co-creation processes significantly improve the usability and effectiveness of DTx interventions. Findings underscore challenges in DTx implementation, including complex regulatory processes, digital inequality, high development costs, and difficulties in integrating with existing healthcare systems. Despite the existence of discrete examples of co-creation in DTx and its acknowledged value in the healthcare domain, systematic research in this field remains markedly limited. Future studies should prioritise establishing best practises for co-creation, with particular emphasis on methods to enhance data privacy and security, standardisation protocols, and patient engagement strategies to optimise DTx adoption and effectiveness. This review contributes to the growing body of literature on DTx by highlighting the potential of co-creation while also identifying critical areas for future research.

Background/Objectives: The rapid ageing of the European population presents growing challenges for mental health, highlighting the need to identify factors that can prevent or delay psychological decline and promote a higher quality of life in later life. This study aims to provide an updated and comprehensive overview of mental health among older adults in Europe by examining the prevalence of depressive symptoms and identifying key associated factors. Methods: We analysed data from individuals (n = 45,601) aged 65 years and older across 27 European countries and Israel who participated in Wave 9 of the Survey of Health, Ageing and Retirement in Europe (SHARE). This study assessed the prevalence of depressive symptoms, which were evaluated using the EURO-D scale (score range: 0–12), with a cut-off of ≥4 indicating clinically relevant symptoms. It also explored associations with sociodemographic characteristics, physical health, behavioural factors, social participation, internet skills and living conditions. Results: Our findings confirm that depressive symptoms remain highly prevalent among older adults in Europe, with 35.1% of women and 21.5% of men affected, reflecting persistent gender disparities in mental health. Depression in later life was significantly associated with poor physical health, loneliness and lower quality of life. Conversely, moderate involvement in grandchild care and in social participation emerged as potential protective factors. Conclusions: Late-life depression has substantial implications for both mental and physical well-being. Our findings suggest that social integration, gender related factors and physical health are closely associated with depressive symptoms in older adults. These associations highlight the importance of considering these domains when designing interventions and policies aimed at promoting mental health in ageing populations.

With Europe’s ageing population and rising demand for palliative care, it is crucial to examine the use of palliative care among older adults during their last years of life and understand the factors influencing their access and end-of-life circumstances. This study employed a cohort of SHARE participants aged 65 years or older who had passed away between Wave 6 (2015) and Wave 7 (2017). Information on death circumstances, palliative care utilization, and associated variables were analysed. The study revealed that nearly 13.0% of individuals across these countries died under palliative care, with Slovenia having the lowest rate (0.3%) and France the highest (30.4%). Palliative care utilization in the last 30 days before death was observed in over 24.0% of participants, with the Czech Republic having the lowest rate (5.0%) and Greece the highest (48.8%). A higher risk of using or dying in palliative care was significantly associated with cognitive impairment (low verbal fluency), physical inactivity, and good to excellent self-perceived health. This work highlights the urgent need for enhanced global access to palliative care and advocates for the cross-country comparison of effective practices within Europe, tailored to the unique healthcare needs of older adults.

Urban environments and climate-related challenges impact older adults’ health and well-being. To address these challenges, climate adaptation strategies and urban design guidelines should be tailored to older adults’ needs. Ethnographic studies can help identify these needs by involving them directly in the research process. This study uses ethnographic research to explore older adults’ perceptions and behaviours regarding climate change risks and impacts, health, and mobility challenges in a vulnerable urban area—São Roque da Lameira, Porto, Portugal. It studies the applicability and complementarity of four participatory methods that can inform urban design: (I) semi-structured interviews, (II) ‘go-along’ interviews, (III) user observations, and (IV) emotional mapping. The qualitative data collected were analysed through thematic and spatial analysis. Common themes emerged between the four methods, including concerns about accessibility, safety, and comfort, such as uneven pavements, lack of seating, and poor infrastructure for people with reduced mobility. Participants recommended improvements, such as more green spaces and better pedestrian infrastructure quality. Notably, each method uncovered distinct dimensions, highlighting the added value of a multi-method approach. This study demonstrates that combining participatory methods offers deeper, context-specific insights to inform age-friendly and climate-resilient urban design. Future research should take climate-focused methods and a multidisciplinary approach into consideration.