The aim of this study was to examine the associations of sleep problems with asthma and allergic rhinitis among Chinese preschoolers. This cross-sectional survey was conducted in Guangzhou, China. Children aged 3–6 years were recruited from 32 kindergartens in 7 administrative districts. Asthma, allergic rhinitis and sleep problems were evaluated using a valid questionnaire. Binary logistic regression models were employed to estimate the odds ratios (OR) and 95% confidence intervals (CI) for the associations of asthma and allergic rhinitis with short sleep duration, late bedtime and frequent nocturnal awakening. We included 4876 preschool children in the current analysis. Of these, 182 (3.7%) diagnosed as asthma, and 511 (10.5%) diagnosed as allergic rhinitis. Frequent nocturnal awakening was associated with asthma and allergic rhinitis, with adjusted OR were 1.49 (95% CI 1.05–2.13) and 1.59 (95% CI 1.27–1.99), respectively. Subgroup analysis showed the OR for frequent nocturnal awakening with asthma was higher in girls (1.68; 95% CI 1.02–2.78) than in boys (1.35; 95% CI 0.81–2.24), but the OR for frequent nocturnal awakening with allergic rhinitis were similar in girls (1.73; 95% CI 1.15–2.30) and boys (1.57; 95% CI 1.17–2.12). No significant associations of short sleep duration and late bedtime with asthma or allergic rhinitis were identified. Our data suggested that frequent nocturnal awakening was associated with asthma and allergic rhinitis among preschoolers, and the association of frequent nocturnal awakening with asthma differed by gender. Further studies are warranted to address the causal relationship between nocturnal awakening and asthma and allergic rhinitis.

Many studies have identified that adverse childhood experiences (ACEs) are associated with non-suicidal self-injury (NSSI) and suicidality. However, most studies have been restricted to a few types of ACEs. This study aims to investigate the association of 13 common types of ACEs with NSSI, suicidal ideation (SI), and suicide attempts (SA), as well as the mediation of depressive and anxiety symptoms therein. A total of 1771 (994 male, 777 female) students aged 11–16 (12.9 ± 0.6) years who participated in the baseline survey of the Chinese Adolescent Health Growth Cohort study were included in the analysis. ACEs, including childhood maltreatment, other common forms of ACEs, and smoking, were measured via the Chinese version of the Child Trauma Questionnaire (CTQ) and a series of valid questionnaires that were derived from previous studies. NSSI was measured using the Chinese version of the Functional Assessment of Self-mutilation. SI and SA were measured using questions derived from the Global School Based Student Health Survey. Depressive symptoms were measured via the Chinese version of the Center for Epidemiologic Studies Depression Scale, and anxiety symptoms were measured via the General Anxiety Disorder-7. Of the included participants, 92.0% reported one or more category of ACEs. Smoking, parent–child separation, emotional abuse, physical abuse, and being bullied were positively associated with NSSI; smoking, parent–child separation, emotional abuse, physical abuse, emotional neglect, and being bullied were positively associated with SI; smoking, emotional abuse, and being bullied were positively associated with SA. The associations of ACEs with NSSI, SI, and SA were each partially or completely mediated through depressive and anxiety symptoms. Children and adolescents who had experiences of smoking, physical abuse, and being bullied during childhood are consistently and independently associated with NSSI and suicidality, and these associations may be largely mediated through depressive and anxiety symptoms. In conclusion, not all the types of ACEs are independently associated with NSSI, and suicidality and other associations may mediate through depressive and anxiety symptoms. Target interventions for adolescents’ NSSI and suicidality should focus on those who have a history of ACEs and depressive and anxiety symptoms.

Many researches have identified that adverse childhood experiences (ACEs) are associated with non-suicidal self-injury (NSSI) and suicidality. However, most studies have been restricted to a few types of ACEs. This study aims to investigate associations of 13 common types of ACEs with NSSI, suicidal ideation (SI) and suicide attempt (SA), as well as the mediation of depressive and anxiety symptoms therein. A total of 1771 students aged 11-16 years who participated in the baseline survey of the Chinese Adolescent Health Growth Cohort study were included for the analysis. ACEs, SI, SA, depressive and anxiety symptoms were recorded by standard questionnaire. Of included participants, 92.0% reported one or more category of ACEs. Smoking, parent-child separation, emotional abuse, physical abuse and being bullied were positively associated with NSSI, with the adjusted odds ratio (aOR) of 2.41(95%CI, 1.01-5.75), 1.80(1.28-2.54), 1.69(1.21-2.37), 2.08(1.44-3.01) and 1.87(1.35-2.59), respectively; smoking (4.03, 1.66-9.81), parent-child separation (1.42, 1.07-1.90), emotional abuse (1.91, 1.41-2.59), physical abuse (1.80, 1.27-2.57), emotional neglect (1.78, 1.28-2.49) and being bullied (2.08, 1.54-2.81) were positively associated with SI; smoking(4.30, 1.67-11.10), emotional abuse (2.42, 1.58-3.72) and being bullied (1.75, 1.17-2.60) were positively associated with SA. The associations of ACEs with NSSI, SI and SA were each partially or completely mediated through depressive and anxiety symptoms. Children and adolescents who had experiences of smoking, physical abuse and being bullied during childhood are consistently and independently associated with NSSI and suicidality, and these associations may be largely mediated through depressive and anxiety symptoms.

Background The aim of this study was to examine the associations of sleep problems with asthma and allergic rhinitis among Chinese preschoolers. Methods This cross-sectional survey was conducted in Guangzhou, China. Children aged 3-6 years were selected from 32 kindergartens in 7 regions. Asthma, allergic rhinitis and sleep problem were evaluated by a valid questionnaire. Binary logistic regression models were employed to estimate the odds ratios (OR) and 95% confidence intervals (CI) for asthma and allergic rhinitis according to short sleep duration, late bedtime and frequent nocturnal awaking. Results We included 4876 preschool children. Of these, 182 (3.7%) diagnosed as asthma, and 511 (10.5%) diagnosed as allergic rhinitis. Frequent nocturnal awakening was associated with asthma and allergic rhinitis, adjusted OR were 1.49(95% CI: 1.05~2.13) and 1.59(95%CI: 1.27-1.99), respectively. Further subgroup analysis showed the association of frequent nocturnal awakening with asthma differed by gender. No significant associations of short duration and late bedtime with asthma/ and allergic rhinitis were identified. Conclusions Our data suggested that frequent nocturnal awakening was associated with asthma and allergic rhinitis, and the association of frequent nocturnal awakening with asthma differed by gender. Further studies are warranted to address the causal relationship between nocturnal awaking and asthma and allergic rhinitis.

Background: Asthma/wheeze and allergic rhinitis are common among pre-school age children, which urgently need to identify more modifiable risk factors for prevention. The aim of this study was to examine the associations of sleep problems with asthma/wheeze and allergic rhinitis among Chinese children aged 0-6 years. Methods: This cross-sectional survey, a part of the National Survey on Physical Growth and Development of Children in nine cities of China (NSPGDC), was conducted in Guangzhou, China. Children aged 0-6 years were randomly selected from 29 communities and 32 kindergartens. Asthma/wheeze, allergic rhinitis and sleep problem were evaluated by a valid questionnaire which was completed by participants’ parent(s). Binary logistic regression models were employed to estimate the odds ratios (OR) and 95% confidence intervals (CI) for asthma/wheeze and allergic rhinitis according to short sleep duration, late bedtime and frequent nocturnal awaking. Results: We included 13376 children aged 0~6 years. Of these, 371 (2.8%) diagnosed as asthma/wheeze, and 610 (4.6%) diagnosed as allergic rhinitis. Frequent nocturnal awakening was associated with asthma/wheeze and allergic rhinitis, adjusted OR were 1.53 (95% CI: 1.20~1.94) and 1.39(1.14-1.71), respectively. Further subgroup analysis showed the association of frequent nocturnal awakening with asthma/wheeze and allergic rhinitis differed by age. No significant associations of short duration and late bedtime with asthma/wheeze and allergic rhinitis were identified. Conclusions: Our data suggested that frequent nocturnal awakening was associated with asthma/wheeze and allergic rhinitis, but this association differed by age. Further studies are warranted to confirm its’ causal association and to understand the underlying mechanisms.