Regenerative Peripheral Nerve Interfaces (RPNIs) encompass neurotized muscle grafts employed for the purpose of amplifying peripheral nerve electrical signaling. The aim of this investigation was to undertake an analysis of the extant literature concerning animal models utilized in the context of RPNIs. A systematic review of the literature of RPNI techniques in animal models was performed in line with the PRISMA statement using the MEDLINE/PubMed and Embase databases from January 1970 to September 2023. Within the compilation of one hundred and four articles employing the RPNI technique, a subset of thirty-five were conducted using animal models across six distinct institutions. The majority (91%) of these studies were performed on murine models, while the remaining (9%) were conducted employing macaque models. The most frequently employed anatomical components in the construction of the RPNIs were the common peroneal nerve and the extensor digitorum longus (EDL) muscle. Through various histological techniques, robust neoangiogenesis and axonal regeneration were evidenced. Functionally, the RPNIs demonstrated the capability to discern, record, and amplify action potentials, a competence that exhibited commendable long-term stability. Different RPNI animal models have been replicated across different studies. Histological, neurophysiological, and functional analyses are summarized to be used in future studies.

Background and Objectives: Tuberous breast is a complex congenital deformity that requires correction of the underlying stenotic anatomy. Clinical evidence on the use of conical polyurethane implants in this setting is limited. To evaluate clinical outcomes and patient-reported satisfaction following correction of tuberous breast deformity using a standardized, implant-assisted reconstructive protocol with exclusive use of conical polyurethane implants. Materials and Methods: An ambispective study included 50 patients with tuberous breast deformity treated between 2020 and 2025 by two surgeons using a standardized implant-assisted reconstructive protocol. All patients underwent systematic glandular ring release and inframammary fold repositioning, followed by placement of conical polyurethane implants. Outcomes included complications, reoperations, and BREAST-Q Augmentation V2.0 scores. The mean follow-up was 17 months (range, 9–24 months). Results: The mean patient age was 29.8 years. According to the Grolleau classification, 62% of patients were type I, 30% type II, and 8% type III. The mean implant volume was 258.2 cc. Overall complication rate was 10%, including one case (2%) of capsular contracture secondary to infection, with a reoperation rate of 8%. Postoperative BREAST-Q scores showed high levels of patient satisfaction, with mean “satisfaction with breasts” scores of 90.1 ± 11.9 and 92.0 ± 9.7 at the first and second postoperative assessments, respectively. Conclusions: Within a standardized reconstructive protocol, conical polyurethane implants were associated with high postoperative patient satisfaction and acceptable complication rates during early-to-mid-term follow-up in the correction of tuberous breast deformity. These findings suggest that the use of conical polyurethane implants within a standardized reconstructive approach is feasible in selected cases. Further comparative studies with longer follow-up are warranted.

Regenerative Peripheral Nerve Interfaces (RPNIs) and Vascularized Denervated Muscle Targets (VDMTs) are emerging strategies for nerve regeneration and myoe