Ship motion is an important factor affecting on the safety of ski-jump take-off. The simplified frigate ship SFS1 was numerically simulated, and the results were compared with the experimental data, the feasibility of the calculation method was verified; Meshless method and WALE turbulence model were used to simulate the process of aircraft ski-jump take-off, aerodynamic characteristics under different rolling conditions during the aircraft ski-jump take-off process were presented. The results showed that: the influence of ship rolling motion on lift coefficient, drag coefficient and pitching moment was small, side force and rolling moment were greatly affected by rolling motion; the region of downwash with the maximum speed was about 10 m from the bow; the safety of ski-jump take-off was greatly affected when aircraft was close to the bow within 20 m.