Aim: The objective of this systematic review was to offer quantitative evidence regarding the influence of surface properties on the mechanical stability of miniscrews. Materials and Methods: The comprehensive search strategy involved querying databases, namely PubMed, Web of Science, and Scopus. PRISMA guidelines were followed to determine relevant studies according to specific eligibility criteria. The final search was conducted on 30 August 2023. In this systematic review, in vivo studies published in the English language were included. Results: A total of 364 articles were viewed, and 17 of them were considered for evaluation. Two of the articles are about human studies, while the rest are about animal studies. The number of miniscrew samples ranged between 18 and 144 (totaling 1097 with a mean of 64.52). Among the surface modifications in the articles, the sandblasting with large grit and acid etching (SLA) method was most frequently applied, followed by acid etching in second place. The control groups’ (machined surface) maximum removal torque (MRT) values varied from 2.05 to 50.50 Ncm, while maximum insertion torque (MIT) values varied from 7.23 to 19.25 Ncm. Conclusions: The development of novel applications to improve the surface properties and survival rates of miniscrews is ongoing. In future studies, emerging surface modifications should be evaluated clinically, taking into account their cost and associated harm to the environment.