For decades, there has been increasing interest in pharmaceuticals’ prevalence in water bodies. This represents a major challenge in providing clean water, free from pharmaceutical contaminants, in different parts of the world. The misuse and overuse of pharmaceuticals, their elevated concentrations in surface waters, and their negative impacts on humans, aquatic organisms, and ecosystems cannot be ignored. Significant efforts have been made toward the discovery of efficient water treatment techniques. Various technologies have been researched and applied, including co-precipitation, membrane separation, ion-exchange, oxidation, adsorption, and biochemical processes. Amidst these technologies, adsorption is considered a promising due to its unique advantages. This review discusses the pharmaceuticals that have been detected in surface waters in concentrations ranging from ng/L to μg/L. It also offers insights into the diverse applications of low-cost adsorbents to deal with pharmaceutical water pollutants and various parameters influencing the adsorption process. This article will assist in promoting the utilization of sustainable, low-cost adsorbents with high adsorption efficiencies in the water treatment process, and it will aid environmentalists in devising strategies for anticipated challenges and provide policymakers with valuable guidance.