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Surface-enhanced Raman scattering (SERS) has been recognized as a powerful tool for biosensors due to the ultrahigh sensitivity and unique fingerprint information. However, there are some limitations in trace target nucleic acid detection for the restricted signal-transducing and amplification strategies. Inspired by CRISPR/Cas12a with specific target DNA-activated collateral single-strand DNA (ssDNA) cleavage activity and liposome with signal molecule-loading properties, we first proposed a sensitive SERS-based on-site nucleic acid detection strategy mediated by CRISPR/Cas12a with trans-cleavage activity on ssDNA linkers utilized to capture liposomes. Liposomes loading two kinds of signal molecules, 4-nitrothiophenol (4-NTP) and cysteine, could achieve the dual-mode detection of target DNA with SERS and naked eye, respectively. The promptly amplified signals were initiated by the triggered breakdown of signal molecule-loaded liposomes. Emancipated 4-NTP, a biological-silent Raman reporter, would achieve highly selective and sensitive SERS measurement. Released cysteine induced the aggregation of plasmonic gold nanoparticles, leading to an obvious red to blue colorimetric shift to realize portable naked-eye detection. With this strategy, target nucleic acid concentration was dexterously converted into SERS and visualization signals and could be detected as low as 100 aM and 10 pM, respectively. The approach was also successfully applied to determine meat adulteration, achieving the detection of a low adulteration ratio in the complicated food matrix. We anticipate that this strategy will not only be regarded as a universal platform for the on-site detection of food authenticity but also broaden SERS application for the accurate determination of diverse biomarkers.
Jianghua Liu; Jiahui Chen; Di Wu; Mingquan Huang; Jian Chen; Ruiyuan Pan; Yongning Wu; Guoliang Li. CRISPR-/Cas12a-Mediated Liposome-Amplified Strategy for the Surface-Enhanced Raman Scattering and Naked-Eye Detection of Nucleic Acid and Application to Food Authenticity Screening. Analytical Chemistry 2021, 93, 10167 -10174.
AMA StyleJianghua Liu, Jiahui Chen, Di Wu, Mingquan Huang, Jian Chen, Ruiyuan Pan, Yongning Wu, Guoliang Li. CRISPR-/Cas12a-Mediated Liposome-Amplified Strategy for the Surface-Enhanced Raman Scattering and Naked-Eye Detection of Nucleic Acid and Application to Food Authenticity Screening. Analytical Chemistry. 2021; 93 (29):10167-10174.
Chicago/Turabian StyleJianghua Liu; Jiahui Chen; Di Wu; Mingquan Huang; Jian Chen; Ruiyuan Pan; Yongning Wu; Guoliang Li. 2021. "CRISPR-/Cas12a-Mediated Liposome-Amplified Strategy for the Surface-Enhanced Raman Scattering and Naked-Eye Detection of Nucleic Acid and Application to Food Authenticity Screening." Analytical Chemistry 93, no. 29: 10167-10174.
The genus Alternaria is widely distributed in the environment. Numerous species of the genus Alternaria can produce a variety of toxic secondary metabolites, called Alternaria mycotoxins. In this review, natural occurrence, toxicity, metabolism, and analytical methods are introduced. The contamination of these toxins in foodstuffs is ubiquitous, and most of these metabolites present genotoxic and cytotoxic effects. Moreover, Alternaria toxins are mainly hydroxylated to catechol metabolites and combined with sulfate and glucuronic acid in in vitro arrays. A more detailed summary of the metabolism of Alternaria toxins is presented in this work. To effectively detect and determine the mycotoxins in food, analytical methods with high sensitivity and good accuracy are also reviewed. This review will guide the formulation of maximum residue limit standards in the future, covering both toxicity and metabolic mechanism of Alternaria toxins.
Anqi Chen; Xin Mao; Qinghui Sun; Zixuan Wei; Juan Li; Yanli You; Jiqiang Zhao; Guibin Jiang; Yongning Wu; Liping Wang; Yanshen Li. Alternaria Mycotoxins: An Overview of Toxicity, Metabolism, and Analysis in Food. Journal of Agricultural and Food Chemistry 2021, 69, 7817 -7830.
AMA StyleAnqi Chen, Xin Mao, Qinghui Sun, Zixuan Wei, Juan Li, Yanli You, Jiqiang Zhao, Guibin Jiang, Yongning Wu, Liping Wang, Yanshen Li. Alternaria Mycotoxins: An Overview of Toxicity, Metabolism, and Analysis in Food. Journal of Agricultural and Food Chemistry. 2021; 69 (28):7817-7830.
Chicago/Turabian StyleAnqi Chen; Xin Mao; Qinghui Sun; Zixuan Wei; Juan Li; Yanli You; Jiqiang Zhao; Guibin Jiang; Yongning Wu; Liping Wang; Yanshen Li. 2021. "Alternaria Mycotoxins: An Overview of Toxicity, Metabolism, and Analysis in Food." Journal of Agricultural and Food Chemistry 69, no. 28: 7817-7830.
The contents of 62 fatty acids, including saturated fatty acids (SFA) and trans fatty acids (TFA) in 192 composites from the 6th (2015–2018) Chinese Total Diet Study (TDS) were determined using gas chromatography (GC) with flame ionization detector (FID). The contents of total fat, SFA, and TFA varied greatly among various food categories with meats recording the highest level. The TFA intake for adult males was 0.19 ± 0.10 percentage of total energy intake (% E) within an range of 0.08−0.42% E, which was lower than the maximum (1% E) recommended by the World Health Organization (WHO), while the intakes of total fat and SFA were 29.51 ± 6.01 % E and 7.01 ± 1.95 % E respectively. Comparing to the 5th Chinese TDS, the intakes of SFA and TFA, which were statistically significant, had been reduced by 8.1 % and 30.18 %, indicating the dietary variations for Chinese.
Ziwei Pei; Lei Zhang; Congrong Fang; Jie Yang; Jingguang Li; Yunfeng Zhao; Yongning Wu. Assessment of dietary intakes of total fat and fatty acids for residents in China in 2015-2018. Journal of Food Composition and Analysis 2021, 102, 104045 .
AMA StyleZiwei Pei, Lei Zhang, Congrong Fang, Jie Yang, Jingguang Li, Yunfeng Zhao, Yongning Wu. Assessment of dietary intakes of total fat and fatty acids for residents in China in 2015-2018. Journal of Food Composition and Analysis. 2021; 102 ():104045.
Chicago/Turabian StyleZiwei Pei; Lei Zhang; Congrong Fang; Jie Yang; Jingguang Li; Yunfeng Zhao; Yongning Wu. 2021. "Assessment of dietary intakes of total fat and fatty acids for residents in China in 2015-2018." Journal of Food Composition and Analysis 102, no. : 104045.
Polychlorinated naphthalenes (PCNs) are carcinogenic contaminants. Residues from historical production and ongoing unintentional releases from industrial thermal sources have led to the ubiquitous presence of PCNs in the environment. Our previous study has revealed that unintentional releases may be the main sources of PCNs in human milk from China. However, an assessment of PCN burden in human milk and exposure differences between historical residues and unintentional release exposure has not been conducted. In this study, we performed the first comparison of human exposure to PCNs and evaluated the differences between the estimated health risks from historical residues and unintentional releases. Three characteristic PCN congener patterns found in Chinese human milk specimens collected from 100 cities/counties can be considered characteristic of PCN exposures in regions with unintentional industrial releases as the main PCN sources. The health risk assessment suggested potential noncarcinogenic health effects in infants aged 0–6 months. The hazard index calculated for infants in Sweden indicates a strong impact of historical residues that nonetheless decreases over time, and a comparison of the hazard indices calculated for China and Ireland suggests that ongoing unintentional formation and release of PCNs from industrial processes should be a matter of public health concern.
Cui Li; Jingguang Li; Bing Lyu; Yongning Wu; Lili Yang; Minghui Zheng; Yihao Min; Lei Zhang; Guorui Liu. Burden and Risk of Polychlorinated Naphthalenes in Chinese Human Milk and a Global Comparison of Human Exposure. Environmental Science & Technology 2021, 55, 6804 -6813.
AMA StyleCui Li, Jingguang Li, Bing Lyu, Yongning Wu, Lili Yang, Minghui Zheng, Yihao Min, Lei Zhang, Guorui Liu. Burden and Risk of Polychlorinated Naphthalenes in Chinese Human Milk and a Global Comparison of Human Exposure. Environmental Science & Technology. 2021; 55 (10):6804-6813.
Chicago/Turabian StyleCui Li; Jingguang Li; Bing Lyu; Yongning Wu; Lili Yang; Minghui Zheng; Yihao Min; Lei Zhang; Guorui Liu. 2021. "Burden and Risk of Polychlorinated Naphthalenes in Chinese Human Milk and a Global Comparison of Human Exposure." Environmental Science & Technology 55, no. 10: 6804-6813.
Perchlorate in various foods continuously arouses public health concern. Bioavailability is a critical parameter to better estimate perchlorate exposure from diets. In this study, perchlorate bioavailability in five foods was determined in an in vivo mouse model and compared with in vitro bioaccessibility/bioavailability. The estimated in vivo perchlorate bioavailability for different foods ranged from 18.01 ± 4.53% to 45.60 ± 7.11%, with the order lettuce > pork > rice > milk powder > soybean. Moisture, fiber, and fat in foods were identified as critical factors affecting perchlorate bioavailability (correlation r = 0.71, 0.52, and −0.67, respectively). Linear regression analysis revealed that the in vitro perchlorate bioavailability determined using the Caco-2 cell model has the potential to estimate the in vivo perchlorate bioavailability in foods (R2 = 0.67, slope = 1.33, and y intercept = 4.99). These findings provide insights into the effects of the food matrices on perchlorate bioavailability and could contribute to decrease the uncertainty regarding perchlorate dietary exposure risk assessment.
Xin Liu; Hu Zhang; Yimei Tian; Min Fang; Lin Xu; Qiao Wang; Jingguang Li; Haitao Shen; Yongning Wu; Zhiyong Gong. Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment. Journal of Agricultural and Food Chemistry 2021, 69, 5189 -5197.
AMA StyleXin Liu, Hu Zhang, Yimei Tian, Min Fang, Lin Xu, Qiao Wang, Jingguang Li, Haitao Shen, Yongning Wu, Zhiyong Gong. Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment. Journal of Agricultural and Food Chemistry. 2021; 69 (17):5189-5197.
Chicago/Turabian StyleXin Liu; Hu Zhang; Yimei Tian; Min Fang; Lin Xu; Qiao Wang; Jingguang Li; Haitao Shen; Yongning Wu; Zhiyong Gong. 2021. "Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment." Journal of Agricultural and Food Chemistry 69, no. 17: 5189-5197.
Microplastics (MPs) are distributed in the oceans, freshwater, and soil environment and have become major pollutants. MPs are generally referred to as plastic particles less than 5 mm in diameter. They consist of primary microplastics synthesized in microscopic size manufactured production and secondary microplastics generated by physical and environmental degradation. Plastic particles are long-lived pollutants that are highly resistant to environmental degradation. In this review, the distribution and possible sources of MPs in aquatic and terrestrial environments are described. Moreover, the adverse effects of MPs on natural creatures due to ingestion have been discussed. We also have summarized identification methods based on MPs particle size and chemical bond. To control the pollution of MPs, the biodegradation of MPs under the action of different microbes has also been reviewed in this work. This review will contribute to a better understanding of MPs pollution in the environment, as well as their identification, toxicity, and biodegradation in the ocean, freshwater, and soil, and the assessment and control of microplastics exposure.
Qinghui Sun; Juan Li; Chen Wang; Anqi Chen; Yanli You; Shupeng Yang; Huihui Liu; Guibin Jiang; Yongning Wu; Yanshen Li. Research progress on distribution, sources, identification, toxicity, and biodegradation of microplastics in the ocean, freshwater, and soil environment. Frontiers of Environmental Science & Engineering 2021, 16, 1 -14.
AMA StyleQinghui Sun, Juan Li, Chen Wang, Anqi Chen, Yanli You, Shupeng Yang, Huihui Liu, Guibin Jiang, Yongning Wu, Yanshen Li. Research progress on distribution, sources, identification, toxicity, and biodegradation of microplastics in the ocean, freshwater, and soil environment. Frontiers of Environmental Science & Engineering. 2021; 16 (1):1-14.
Chicago/Turabian StyleQinghui Sun; Juan Li; Chen Wang; Anqi Chen; Yanli You; Shupeng Yang; Huihui Liu; Guibin Jiang; Yongning Wu; Yanshen Li. 2021. "Research progress on distribution, sources, identification, toxicity, and biodegradation of microplastics in the ocean, freshwater, and soil environment." Frontiers of Environmental Science & Engineering 16, no. 1: 1-14.
Bee products have been considered as functional foods for a long time in China because of their wide range of biological activity. China has the largest number of bee colonies and the highest production of bee products in the world. Major bee products include honey, royal jelly, propolis and bee pollen. In recent years, consumption of bee products in China has been increasing due to an increased public awareness of their nutritional and health benefits. With the development of the Chinese economy and the improvement of people’s living standards, high-end and gift-oriented products have become more popular and bee products are one of the options. However, the production of bee products cannot increase rapidly in short term and this is a driver for substantial economic-motivated adulteration. This is compounded by globalisation of supply chains which has also resulted in a rise in bee products fraud. These illicit products are eroding market prices and consumer trust, causing significant damage to the beekeeping industry. In order to provide information or solutions for regulators and consumers, in this article, we review he characteristics of bee products in China and the current situation regarding adulteration and authenticity of bee products. Moreover, advances in analytical techniques for detection of adulteration and authenticity of bee products including sensory techniques, DNA methods, isotope ratio mass spectrometry, spectroscopic techniques and mass spectrometry are reviewed. Finally, the applications and limitations of analytical methods in authentication are critically assessed. Suggestions are also put forward for the future management of China’s bee products industry.
Ziying Wang; Pingping Ren; Yongning Wu; Qinghua He. Recent advances in analytical techniques for the detection of adulteration and authenticity of bee products – A review. Food Additives & Contaminants: Part A 2021, 38, 533 -549.
AMA StyleZiying Wang, Pingping Ren, Yongning Wu, Qinghua He. Recent advances in analytical techniques for the detection of adulteration and authenticity of bee products – A review. Food Additives & Contaminants: Part A. 2021; 38 (4):533-549.
Chicago/Turabian StyleZiying Wang; Pingping Ren; Yongning Wu; Qinghua He. 2021. "Recent advances in analytical techniques for the detection of adulteration and authenticity of bee products – A review." Food Additives & Contaminants: Part A 38, no. 4: 533-549.
Deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON) and 15-acetyldeoxynivalenol (15-ADON) are type B trichothecenes; one of the major pollutants in food and feed products. Although the toxicity of DON has been well documented, information on the toxicity of its acetylated derivative remains incomplete. To acquire more detailed insight into 3-ADON and 15-ADON, Caco-2 cells under 0.5 µM DON, 3-ADON and 15-ADON treatment for 24 h were subjected to RNA-seq analysis. In the present study, 2656, 3132 and 2425 differentially expressed genes (DEGs) were selected, respectively, and were enriched utilizing the Kyoto Encyclopedia of Genes and Genomes (KEGG) and the Gene Ontology (GO) database. The upregulation of ataxia-telangiectasia mutated kinase (ATM), WEE1 homolog 2 (WEE2) and downregulation of proliferating cell nuclear antigen (PCNA), minichromosome maintenance (MCMs), cyclin dependent kinase (CDKs), and E2Fs indicate that the three toxins induced DNA damage, inhibition of DNA replication and cell cycle arrest in Caco-2 cells. Additionally, the upregulation of sestrin (SENEs) and NEIL1 implied that the reason for DNA damage may be attributable to oxidative stress. Our study provides insight into the toxic mechanism of 3-ADON and 15-ADON.
Yuyun He; Xiaoyao Yin; Jingjing Dong; Qing Yang; Yongning Wu; Zhiyong Gong. Transcriptome Analysis of Caco-2 Cells upon the Exposure of Mycotoxin Deoxynivalenol and Its Acetylated Derivatives. Toxins 2021, 13, 167 .
AMA StyleYuyun He, Xiaoyao Yin, Jingjing Dong, Qing Yang, Yongning Wu, Zhiyong Gong. Transcriptome Analysis of Caco-2 Cells upon the Exposure of Mycotoxin Deoxynivalenol and Its Acetylated Derivatives. Toxins. 2021; 13 (2):167.
Chicago/Turabian StyleYuyun He; Xiaoyao Yin; Jingjing Dong; Qing Yang; Yongning Wu; Zhiyong Gong. 2021. "Transcriptome Analysis of Caco-2 Cells upon the Exposure of Mycotoxin Deoxynivalenol and Its Acetylated Derivatives." Toxins 13, no. 2: 167.
Ligang Hu; Jie Gao; Linlin Yao; Li Zeng; Qian Liu; QunFang Zhou; Haiyan Zhang; Dawei Lu; Jianjie Fu; Min Li; Xingchen Zhao; Xingwang Hou; Jianbo Shi; Lihong Liu; Yingying Guo; Yawei Wang; Guang-Guo Ying; Yong Cai; Maosheng Yao; Zongwei Cai; Yongning Wu; Guangbo Qu; Guibin Jiang. Evidence of Foodborne Transmission of the Coronavirus (COVID-19) through the Animal Products Food Supply Chain. Environmental Science & Technology 2021, 55, 2713 -2716.
AMA StyleLigang Hu, Jie Gao, Linlin Yao, Li Zeng, Qian Liu, QunFang Zhou, Haiyan Zhang, Dawei Lu, Jianjie Fu, Min Li, Xingchen Zhao, Xingwang Hou, Jianbo Shi, Lihong Liu, Yingying Guo, Yawei Wang, Guang-Guo Ying, Yong Cai, Maosheng Yao, Zongwei Cai, Yongning Wu, Guangbo Qu, Guibin Jiang. Evidence of Foodborne Transmission of the Coronavirus (COVID-19) through the Animal Products Food Supply Chain. Environmental Science & Technology. 2021; 55 (5):2713-2716.
Chicago/Turabian StyleLigang Hu; Jie Gao; Linlin Yao; Li Zeng; Qian Liu; QunFang Zhou; Haiyan Zhang; Dawei Lu; Jianjie Fu; Min Li; Xingchen Zhao; Xingwang Hou; Jianbo Shi; Lihong Liu; Yingying Guo; Yawei Wang; Guang-Guo Ying; Yong Cai; Maosheng Yao; Zongwei Cai; Yongning Wu; Guangbo Qu; Guibin Jiang. 2021. "Evidence of Foodborne Transmission of the Coronavirus (COVID-19) through the Animal Products Food Supply Chain." Environmental Science & Technology 55, no. 5: 2713-2716.
The copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) click reaction has drawn increasing attention in the field of analytical science. However, the poor stability of Cu(I) usually hinders not only the simplicity of the click reaction but also its applications in precise analyses. Therefore, the development of a nanocatalyst containing stable Cu(I) is of great significance for broadening the application of CuAAC-based assays. Herein, inspired by the active center structure of natural multicopper oxidases (MCOs), we successfully prepared a novel nanocatalyst containing abundant stable Cu(I) as an artificial “clickase” (namely, CCN) by using glutathione to stabilize Cu(I). The stability and enzyme-like catalytic activity in the CuAAC reaction of the prepared CCN clickase were studied, and the catalytic mechanism of the CCN clickase-mediated CuAAC reaction between 3-azide-7-hydroxycoumarin (Azide 1) and propargyl alcohol (Alkyne 2) was also revealed. Compared with the existing solid CuO nanocatalysts used in CuAAC-based assays, CCN clickases exhibited plenty of superior properties (including high stability, excellent catalytic activity, no requirements of dissolution and reducing agents/radical initiator during the detection, well-defined porosities benefiting the substrate diffusion, and good biocompatibility), which can greatly increase the reaction efficiency and shorten the detection time. Encouraged by these remarkable performances, CCN clickases were used as labels to establish a new catalytic click fluorescence immunoassay for foodborne pathogens. Notably, the proposed CCN clickase-based immunoassay exhibited high analytical performances for the quantification of Salmonella enteritidis in the linear range of 102–106 CFU/mL with a limit of detection as low as 11 CFU/mL. The developed method has also been used in the determination of S. enteritidis in food samples, showing its great potential in the detection of foodborne pathogens.
Xianlong Zhang; Yongning Wu; Juhong Chen; Yan Yang; Guoliang Li. Bioinspired Artificial “Clickase” for the Catalytic Click Immunoassay of Foodborne Pathogens. Analytical Chemistry 2021, 93, 3217 -3225.
AMA StyleXianlong Zhang, Yongning Wu, Juhong Chen, Yan Yang, Guoliang Li. Bioinspired Artificial “Clickase” for the Catalytic Click Immunoassay of Foodborne Pathogens. Analytical Chemistry. 2021; 93 (6):3217-3225.
Chicago/Turabian StyleXianlong Zhang; Yongning Wu; Juhong Chen; Yan Yang; Guoliang Li. 2021. "Bioinspired Artificial “Clickase” for the Catalytic Click Immunoassay of Foodborne Pathogens." Analytical Chemistry 93, no. 6: 3217-3225.
Concentrations of bisphenol A (BPA) and its analogues (together with their chlorinated derivatives are referred to as BPs) were measured in 181 breastmilk samples collected from 9 provinces in China in 2014. Twelve BP types were found. The BP concentrations ranged from not detected to 5.912 μg/L. BPA was the predominant BP, followed by bisphenol F (BPF) and bisphenol S (BPS). The mean BPA, BPF, and BPS levels were 0.444, 0.107, and 0.027 μg/L, respectively. Other BPs were sporadically detected in breastmilk samples. There were no differences (p > 0.05) in BPA, BPF, BPS, or total BP levels in the urban and rural regions or the northern and southern regions. BPA accounted for approximately 70% of the BPs and BPF accounted for more than 20% of the BPs in breast milk samples. The high contribution of BPF indicated that BPA analogues, not only BPA, should receive attention. The upper-bound daily intakes of BPs for infants 0–6 months old were 0.044–1.291 μg/kg bw/day. Despite the absence of tolerable daily intake data, attention should be paid not only on BPA but also BPF.
Yumin Niu; Bin Wang; Runhui Yang; Yongning Wu; Yunfeng Zhao; Cuizhi Li; Jing Zhang; Yang Xing; Bing Shao. Bisphenol Analogues and Their Chlorinated Derivatives in Breast Milk in China: Occurrence and Exposure Assessment. Journal of Agricultural and Food Chemistry 2021, 69, 1391 -1397.
AMA StyleYumin Niu, Bin Wang, Runhui Yang, Yongning Wu, Yunfeng Zhao, Cuizhi Li, Jing Zhang, Yang Xing, Bing Shao. Bisphenol Analogues and Their Chlorinated Derivatives in Breast Milk in China: Occurrence and Exposure Assessment. Journal of Agricultural and Food Chemistry. 2021; 69 (4):1391-1397.
Chicago/Turabian StyleYumin Niu; Bin Wang; Runhui Yang; Yongning Wu; Yunfeng Zhao; Cuizhi Li; Jing Zhang; Yang Xing; Bing Shao. 2021. "Bisphenol Analogues and Their Chlorinated Derivatives in Breast Milk in China: Occurrence and Exposure Assessment." Journal of Agricultural and Food Chemistry 69, no. 4: 1391-1397.
Persistent organic pollutants (POPs) remain a major point of concern worldwide, and surveillance monitoring of these contaminants presents a significant challenge. Here, we conducted an assessment of combined exposure to multiple POPs components [10 perfluoroalkyl acids (PFAAs), seven polybrominated diphenyl ethers (PBDEs), six polychlorinated biphenyls (PCBs) and 29 dioxin-like compounds (DLCs)] in relation to gestational diabetes mellitus (GDM) risk, and determined the identification and prioritization of potent components in these POPs mixtures. The results indicated a significant mixture effect and the combined exposure index estimated from multiple POPs components was associated with GDM and glucose homeostasis (P < 0.001). Based on the mixture effects on GDM, the procedure of prioritization identified DLCs as the components of the greatest concern, although at the lowest body burden in the population compared with PBDEs, PFAAs, and PCBs. For glucose homeostasis, BDE-153 was the chemical of top-ranked priority of concern. The final effect-based prioritized list of POPs was DLCs > PBDEs >PFAAs > PCBs. This prioritization is important for developing a more cost-effective regulation framework focusing on the POPs components of the greatest concern to human health.
Xin Liu; Lei Zhang; Liangkai Chen; Jingguang Li; Jun Wang; Yunfeng Zhao; Liegang Liu; Yongning Wu. Identification and prioritization of the potent components for combined exposure of multiple persistent organic pollutants associated with gestational diabetes mellitus. Journal of Hazardous Materials 2021, 409, 124905 .
AMA StyleXin Liu, Lei Zhang, Liangkai Chen, Jingguang Li, Jun Wang, Yunfeng Zhao, Liegang Liu, Yongning Wu. Identification and prioritization of the potent components for combined exposure of multiple persistent organic pollutants associated with gestational diabetes mellitus. Journal of Hazardous Materials. 2021; 409 ():124905.
Chicago/Turabian StyleXin Liu; Lei Zhang; Liangkai Chen; Jingguang Li; Jun Wang; Yunfeng Zhao; Liegang Liu; Yongning Wu. 2021. "Identification and prioritization of the potent components for combined exposure of multiple persistent organic pollutants associated with gestational diabetes mellitus." Journal of Hazardous Materials 409, no. : 124905.
Si Chen; Juana Du; Fangmin Gong; Hongwei Han; Jianwen Li; Jinjun Liang; Patrick Wall; Yongning Wu; Zhenyi Li; Changsha Hunan Disease Prevention And Control Center. Upgrading from One-way Informing to Two-way Audience-oriented Health Communication: CFSA Initiations for World Food Safety Day. China CDC Weekly 2021, 3, 523 -525.
AMA StyleSi Chen, Juana Du, Fangmin Gong, Hongwei Han, Jianwen Li, Jinjun Liang, Patrick Wall, Yongning Wu, Zhenyi Li, Changsha Hunan Disease Prevention And Control Center. Upgrading from One-way Informing to Two-way Audience-oriented Health Communication: CFSA Initiations for World Food Safety Day. China CDC Weekly. 2021; 3 (24):523-525.
Chicago/Turabian StyleSi Chen; Juana Du; Fangmin Gong; Hongwei Han; Jianwen Li; Jinjun Liang; Patrick Wall; Yongning Wu; Zhenyi Li; Changsha Hunan Disease Prevention And Control Center. 2021. "Upgrading from One-way Informing to Two-way Audience-oriented Health Communication: CFSA Initiations for World Food Safety Day." China CDC Weekly 3, no. 24: 523-525.
Di Wu; Christopher Elliott; Yongning Wu. Food Safety Strategies: The One Health Approach to Global Challenges and China’s Actions. China CDC Weekly 2021, 3, 507 -513.
AMA StyleDi Wu, Christopher Elliott, Yongning Wu. Food Safety Strategies: The One Health Approach to Global Challenges and China’s Actions. China CDC Weekly. 2021; 3 (24):507-513.
Chicago/Turabian StyleDi Wu; Christopher Elliott; Yongning Wu. 2021. "Food Safety Strategies: The One Health Approach to Global Challenges and China’s Actions." China CDC Weekly 3, no. 24: 507-513.
Information on the burden of disease due to foodborne pathogens in China is quite limited. To understand the incidence of foodborne gastroenteritis due to non-typhoidal Salmonella enterica and Vibrio parahaemolyticus, population survey and sentinel hospital surveillance were conducted during July 2010 to June 2011 in Shanghai, east China, and a model for calculating disease burden was established. The multiplier for gastroenteritis caused by these pathogens was estimated at 59 [95% confidence interval (CI) 30–102]. Annual incidence per 100,000 population in Shanghai was estimated as 48 (95% CI 24–83) and 183 (95% CI 93–317) cases for foodborne non-typhoidal salmonellosis and V. parahaemolyticus gastroenteritis, respectively, illustrating that bacterial gastroenteritis due to these two pathogens poses a substantial health burden. There is a significant difference between our simulated incidence and the data actually reported for foodborne diseases, indicating significant underreporting and underdiagnosis of non-typhoidal S. enterica and V. parahaemolyticus gastroenteritis in the surveillance area. The present research demonstrates basic situation of the health burden caused by major foodborne pathogens in the surveillance area. Enhanced laboratory-based sentinel hospital surveillance is one of the effective ways to monitor food safety in east China.
Yan Chen; Hong Liu; Min Chen; He-Yang Sun; Yong-Ning Wu. The human health burden of non-typhoidal Salmonella enterica and Vibrio parahaemolyticus foodborne gastroenteritis in Shanghai, east China. PLOS ONE 2020, 15, e0242156 .
AMA StyleYan Chen, Hong Liu, Min Chen, He-Yang Sun, Yong-Ning Wu. The human health burden of non-typhoidal Salmonella enterica and Vibrio parahaemolyticus foodborne gastroenteritis in Shanghai, east China. PLOS ONE. 2020; 15 (11):e0242156.
Chicago/Turabian StyleYan Chen; Hong Liu; Min Chen; He-Yang Sun; Yong-Ning Wu. 2020. "The human health burden of non-typhoidal Salmonella enterica and Vibrio parahaemolyticus foodborne gastroenteritis in Shanghai, east China." PLOS ONE 15, no. 11: e0242156.
Presently, the potential health risks of neonicotinoid insecticides (neonics) are now receiving much attention, but no data regarding the exposure of infants to neonics via human breast milk intake have been reported. In this study, a nationwide survey was conducted during the period of 2017-2019, wherein 97 pooled breast milk samples were collected from 3570 lactating women of 23 provinces in China. Nationally, acetamiprid-N-desmethyl was the most predominant compound, accounting for 61.2% of the total amount of neonics, followed by imidacloprid (15.6%). The concentration of the sum of acetamiprid and its metabolite acetamiprid-N-desmethyl in breast milk was positively correlated with corresponding dietary exposure, while no statistically significant association between the other neonic levels in breast milk and dietary exposure was found. The cumulative daily intakes of neonics (9.40-249 ng kg-1 of body weight day-1) were estimated for breastfed infants, indicating a minuscule risk to Chinese infants from neonic exposure via breastfeeding.
Dawei Chen; Zhibin Liu; Holly Barrett; Jiajun Han; Bing Lv; Yan Li; Jingguang Li; Yunfeng Zhao; Yongning Wu. Nationwide Biomonitoring of Neonicotinoid Insecticides in Breast Milk and Health Risk Assessment to Nursing Infants in the Chinese Population. Journal of Agricultural and Food Chemistry 2020, 1 .
AMA StyleDawei Chen, Zhibin Liu, Holly Barrett, Jiajun Han, Bing Lv, Yan Li, Jingguang Li, Yunfeng Zhao, Yongning Wu. Nationwide Biomonitoring of Neonicotinoid Insecticides in Breast Milk and Health Risk Assessment to Nursing Infants in the Chinese Population. Journal of Agricultural and Food Chemistry. 2020; ():1.
Chicago/Turabian StyleDawei Chen; Zhibin Liu; Holly Barrett; Jiajun Han; Bing Lv; Yan Li; Jingguang Li; Yunfeng Zhao; Yongning Wu. 2020. "Nationwide Biomonitoring of Neonicotinoid Insecticides in Breast Milk and Health Risk Assessment to Nursing Infants in the Chinese Population." Journal of Agricultural and Food Chemistry , no. : 1.
To ensure food safety in livestock industries, developing a non-lethal and cost-effective detection method for the long-term monitoring of veterinary antibiotics in animals will be beneficial to avoid unnecessary losses. In this study, a highly-selective extraction using dispersive micro solid–phase extraction method coupled with an enhanced-sensitivity detection by pre-column dilution injection and liquid chromatography–high resolution mass spectrometry was used to determine the restricted fluoroquinolones (FQs) in swine body fluids. The proposed method showed good linear coefficients higher than 0.999, and high sensitivity with the LODs and LOQs in the range of 0.02-0.03 μg/L and 0.06-0.1 μg/L in swine body fluids, respectively. For further evaluation, the adequate recoveries (85.3-112.8%), satisfactory repeatability (intra-day and inter-day precisions of 2.1%-8.2% and 3.8%-13.7%, respectively), and acceptable matrix effect (0.92-1.12) of the FQs were achieved. It has been successfully applied for analysis of the FQs in body fluids without sacrificing animals in the future.
Rui Wang; Si Li; Dawei Chen; Yunfeng Zhao; Yongning Wu; Kemin Qi. Selective extraction and enhanced-sensitivity detection of fluoroquinolones in swine body fluids by liquid chromatography–high resolution mass spectrometry: Application in long-term monitoring in livestock. Food Chemistry 2020, 341, 128269 .
AMA StyleRui Wang, Si Li, Dawei Chen, Yunfeng Zhao, Yongning Wu, Kemin Qi. Selective extraction and enhanced-sensitivity detection of fluoroquinolones in swine body fluids by liquid chromatography–high resolution mass spectrometry: Application in long-term monitoring in livestock. Food Chemistry. 2020; 341 ():128269.
Chicago/Turabian StyleRui Wang; Si Li; Dawei Chen; Yunfeng Zhao; Yongning Wu; Kemin Qi. 2020. "Selective extraction and enhanced-sensitivity detection of fluoroquinolones in swine body fluids by liquid chromatography–high resolution mass spectrometry: Application in long-term monitoring in livestock." Food Chemistry 341, no. : 128269.
Background: A rapid and simple analytical method for the screening and quantification of multi-residues was established by a quick, easy, cheap, effective, rugged and safe (QuEChERS) approach coupled to ultra-performance liquid chromatography and electrospray ionization quadrupole orbitrap high-resolution mass spectrometry (UPLC-Q-Orbitrap HRMS). A total number of 59 veterinary drugs were investigated, which belonged to 12 classes, such as β-agonist, quinolones, sulfonamides, tetracyclines, lincomycin series, triphenylmethane, nitroimidazoles, macrolides, amide alcohols, quinoxalines, steroid hormone and sedatives. Methods: The factors which influence the determination of veterinary drugs residues, such as mobile phase, extract solvent, clean up sorbent, and re-dissolved solvent, were optimized by the single factor experiment. The method was sufficiently validated by using the parameters of linearity, sensitivity, accuracy, and repeatability. Results: The response of the detector was linear for 59 veterinary drug residues in extensive range (two to three orders of magnitude) with a high coefficient of determination (R2) (0.9995-0.9998). The limit of quantification (LOQ) ranged from 0.1μg/kg to 2.0μg/kg for 59 veterinary drug residues in pork samples. The repeatability was in the range of 1.0%-9.5%. Average recoveries of 59 veterinary drugs at three spiked levels ranged from 53.7%-117.8% with relative standard deviation (RSD) of 1.9%-13.9%. The full MS scan coupled with data-dependent MS/MS mode was applied for screening the target compounds to simultaneously obtain the accurate mass of parent ion and the mass spectrum of fragments. Elemental composition, accurate mass, and retention time and characteristic fragment ions were used to establish a homemade database. Conclusion: The ability of the homemade database was verified by analyzing the real pork samples, and the result was satisfactory.
Liya Wang; Chunyan Qi; Lidan Wang; Tingcai Wang; Yi Lei; Xuefang Zeng; Jiafei Liu; Xuxia Liang; Lixin Huang; Yongning Wu. Rapid Screening and Quantification of Multi-Class Multi-Residue Veterinary Drugs in Pork by a Modified Quechers Protocol Coupled to UPLC-QOrbitrap HRMS. Current Analytical Chemistry 2020, 16, 863 -879.
AMA StyleLiya Wang, Chunyan Qi, Lidan Wang, Tingcai Wang, Yi Lei, Xuefang Zeng, Jiafei Liu, Xuxia Liang, Lixin Huang, Yongning Wu. Rapid Screening and Quantification of Multi-Class Multi-Residue Veterinary Drugs in Pork by a Modified Quechers Protocol Coupled to UPLC-QOrbitrap HRMS. Current Analytical Chemistry. 2020; 16 (7):863-879.
Chicago/Turabian StyleLiya Wang; Chunyan Qi; Lidan Wang; Tingcai Wang; Yi Lei; Xuefang Zeng; Jiafei Liu; Xuxia Liang; Lixin Huang; Yongning Wu. 2020. "Rapid Screening and Quantification of Multi-Class Multi-Residue Veterinary Drugs in Pork by a Modified Quechers Protocol Coupled to UPLC-QOrbitrap HRMS." Current Analytical Chemistry 16, no. 7: 863-879.
Food and environmental safety issues attributable to the polybrominated diphenyl ethers (PBDEs) are gaining increasing attention, and these urge us to establish a high-performance sample-handling technique. In this study, an outstanding adsorption performance with short adsorption time (10 min) was achieved for PBDEs using a novel synthesized dispersive solid-phase extraction adsorbent, a reticulated covalent organic framework with N/O functional groups (i.e., imine linkage, triazine, and methoxy) (TAPT–DMTA–COF). By conducting sufficient experimentation and theoretical simulation on adsorption mechanism, the halogen bond between electronegative N/O atoms of TAPT–DMTA–COF and the electropositive Br atoms of PBDEs were observed to play a more pivotal role than π–π, C–H…π interactions, and hydrophobic effects. Furthermore, the positive linear relation between calculated adsorption energy and Br content directly clarified that enrichment behavior of PBDEs can be attributed to halogen bonding. These data implied that integrated nanostructure (i.e., N/O functional groups and reticulated architecture) effectively enhanced adsorption capacity. In case of PBDE analysis, this approach achieved excellent results with low limits of detection (0.03−0.13 ng L–1). Finally, the promising potential applications of aforementioned method were verified by spiking water, fish, and milk samples with PBDEs; good PBDEs recoveries were obtained.
Lu Liu; Xiao-Xing Wang; Xia Wang; Gui-Ju Xu; Yan-Fang Zhao; Ming-Lin Wang; Jing-Ming Lin; Ru-Song Zhao; Yongning Wu. Triazine-cored covalent organic framework for ultrasensitive detection of polybrominated diphenyl ethers from real samples: Experimental and DFT study. Journal of Hazardous Materials 2020, 403, 123917 .
AMA StyleLu Liu, Xiao-Xing Wang, Xia Wang, Gui-Ju Xu, Yan-Fang Zhao, Ming-Lin Wang, Jing-Ming Lin, Ru-Song Zhao, Yongning Wu. Triazine-cored covalent organic framework for ultrasensitive detection of polybrominated diphenyl ethers from real samples: Experimental and DFT study. Journal of Hazardous Materials. 2020; 403 ():123917.
Chicago/Turabian StyleLu Liu; Xiao-Xing Wang; Xia Wang; Gui-Ju Xu; Yan-Fang Zhao; Ming-Lin Wang; Jing-Ming Lin; Ru-Song Zhao; Yongning Wu. 2020. "Triazine-cored covalent organic framework for ultrasensitive detection of polybrominated diphenyl ethers from real samples: Experimental and DFT study." Journal of Hazardous Materials 403, no. : 123917.
Facile enrichment and determination of trace organophosphorus pesticides (OPPs) in foods has been a constantly pursuing goal in food safety field. Herein, Zr4+-immobilized covalent organic frameworks ([email protected][email protected]4+) have been first constructed and utilized as the powerful adsorbents for magnetic solid-phase extraction (MSPE) of OPPs. Owing to the π-π stacking interaction, hydrogen bonding and Zr4+-phosphate coordination reaction, the composites exhibited excellent selectivity and superior affinity to OPPs. Under optimized conditions, the proposed MSPE method coupled with GC-FPD showed good linearity (R2 ≥ 0.9990) and yielded low limits of detection (0.7-3.0 μg kg−1) for OPPs. Moreover, the developed method was successfully employed for the quantitation of OPPs in spiked vegetable samples and obtained satisfactory recoveries in the range of 87-121% with the relative standard deviations (RSDs) ≤ 8.9%. These results demonstrated that the prepared nanoparticles hold unique advantages for trace OPPs analysis in foodstuffs.
Guoliang Li; Aying Wen; Jianghua Liu; Di Wu; Yongning Wu. Facile extraction and determination of organophosphorus pesticides in vegetables via magnetic functionalized covalent organic framework nanocomposites. Food Chemistry 2020, 337, 127974 .
AMA StyleGuoliang Li, Aying Wen, Jianghua Liu, Di Wu, Yongning Wu. Facile extraction and determination of organophosphorus pesticides in vegetables via magnetic functionalized covalent organic framework nanocomposites. Food Chemistry. 2020; 337 ():127974.
Chicago/Turabian StyleGuoliang Li; Aying Wen; Jianghua Liu; Di Wu; Yongning Wu. 2020. "Facile extraction and determination of organophosphorus pesticides in vegetables via magnetic functionalized covalent organic framework nanocomposites." Food Chemistry 337, no. : 127974.