Dr. Samuele Notarbartolo
Infectious Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Lombardy, Italy
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Academic Career Length
20Years (2007-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 September 2007 in Cell
Journal Article
FSFrancesca De Santa
Francesca De SantaMTMaria Grazia Totaro
Maria Grazia Totaro
EPElena Prosperini
Elena Prosperini
Samuele NotarbartoloGTGiuseppe Testa
Giuseppe TestaGNGioacchino Natoli
Gioacchino Natoli7 December 2021 in European Journal of Immunology
Journal Article
ACAndrea Cossarizza
Andrea CossarizzaHCHyun-Dong Chang
Hyun-Dong ChangARAndreas Radbruch
Andreas Radbruch
SASergio Abrignani
Sergio Abrignani
RARichard Addo
Richard Addo
JYJuhao Yang
Juhao Yang
+187
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical samples with examples of flow cytometry applications in the context of autoimmune diseases, cancers as well as acute and chronic infectious diseases. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid. All sections are written and peer‐reviewed by leading flow cytometry experts and immunologists, making this edition an essential and state‐of‐the‐art handbook for basic and clinical researchers.
24 September 2009 in The EMBO Journal
Journal Article
FSFrancesca De Santa
Francesca De SantaVNVipin Narang
Vipin Narang
ZYZhei Hwee Yap
Zhei Hwee Yap
BTBetsabeh Khoramian Tusi
Betsabeh Khoramian TusiTBThomas Burgold
Thomas Burgold
GNGioacchino Natoli
Gioacchino Natoli +8
Jmjd3, a JmjC family histone demethylase, is induced by the transcription factor NF‐kB in response to microbial stimuli. Jmjd3 erases H3K27me3, a histone mark associated with transcriptional repression and involved in lineage determination. However, the specific contribution of Jmjd3 induction and H3K27me3 demethylation to inflammatory gene expression remains unknown. Using chromatin immunoprecipitation‐sequencing we found that Jmjd3 is preferentially recruited to transcription start sites characterized by high levels of H3K4me3, a marker of gene activity, and RNA polymerase II (Pol\_II). Moreover, 70% of lipopolysaccharide (LPS)‐inducible genes were found to be Jmjd3 targets. Although most Jmjd3 target genes were unaffected by its deletion, a few hundred genes, including inducible inflammatory genes, showed moderately impaired Pol\_II recruitment and transcription. Importantly, most Jmjd3 target genes were not associated with detectable levels of H3K27me3, and transcriptional effects of Jmjd3 absence in the window of time analysed were uncoupled from measurable effects on this histone mark. These data show that Jmjd3 fine‐tunes the transcriptional output of LPS‐activated macrophages in an H3K27 demethylation‐independent manner.
6 July 2020 in Nature Immunology
Journal Article
TWTobias Wolf
Tobias Wolf
WJWenjie Jin
Wenjie Jin
GZGiada Zoppi
Giada Zoppi
IVIan A. Vogel
Ian A. VogelMAMurodzhon Akhmedov
Murodzhon Akhmedov
RGRoger Geiger
Roger Geiger +13
1 February 2010 in Molecular Cell
Journal Article
LGLuca Giorgetti
Luca Giorgetti
TSTrevor Siggers
Trevor Siggers
GTGuido Tiana
Guido TianaGCGreta Caprara
Greta CapraraSamuele NotarbartoloGNGioacchino Natoli
Gioacchino Natoli +4
10 August 2021 in Science Immunology
Journal Article
Samuele NotarbartoloVRValeria Ranzani
Valeria RanzaniABAlessandra Bandera
Alessandra BanderaPGPaola Gruarin
Paola Gruarin
VBValeria Bevilacqua
Valeria Bevilacqua
SASergio Abrignani
Sergio Abrignani +31
Characterization of the immune responses to SARS-CoV-2 reveals a CD8 + T cell subset that likely establishes the memory to the virus.
About Me
Dr. Samuele Notarbartolo is a researcher with extensive experience in Cellular and Molecular Immunology. He has dedicated his professional life to advancing our understanding of the cellular and molecular mechanisms regulating immune system function.Currently, Dr. Notarbartolo is Principal Investigator in the Infectious Disease Unit at the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico in Milan. His research centres on elucidating the transcriptional circuits that regulate the differentiation of memory precursor effector T cells to develop improved vaccine adjuvants. Dr. Notarbartolo earned his Ph.D. in Molecular Medicine in 2011 from the European School of Molecular Medicine under the guidance of Prof. Gioacchino Natoli. During his Postdoc in the "Cellular Immunology" laboratory at the Institute for Research in Biomedicine in Bellinzona (Switzerland), under the supervision of Prof. Federica Sallusto, he investigated the molecular mechanisms governing T-cell identity and plasticity in physiology and pathology. Between 2020 and 2023, he was a Junior Principal Investigator at the National Institute of Molecular Genetics in Milan, where he studied the molecular circuits that define cell identity and function in human anti-tumour CD4+ T lymphocytes. Dr. Notarbartolo is a member of the Italian Society of Immunology, Clinical Immunology and Allergology (SIICA) and the Italian Society of Biology and General and Molecular Genetics (AIBG).
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