Andrea Cossarizza

Prof. Andrea Cossarizza

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Academic Career Length

41Years (1986-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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17 August 2007 in Science
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Journal Article
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JFJacques Fellay
Jacques Fellay
KSKevin V. Shianna
Kevin V. Shianna
DGDongliang Ge
Dongliang Ge
SCSara Colombo
Sara Colombo
BLBruno Ledergerber
Bruno Ledergerber
DGDavid B. Goldstein
David B. Goldstein
Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen ( HLA )– B*5701 , whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
21 October 2019 in European Journal of Immunology
Verified
Journal Article
Open access
ACAndrea Cossarizza
Andrea Cossarizza
HCHyun-Dong Chang
Hyun-Dong Chang
ARAndreas Radbruch
Andreas Radbruch
AAAndreas Acs
Andreas Acs
DADieter Adam
Dieter Adam
AZArturo Zychlinsky
Arturo Zychlinsky
These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer‐reviewed by leading experts in the field, making this an essential research companion.
7 July 1997 in FEBS Letters
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Journal Article
Closed access
SSStefano Salvioli
Stefano Salvioli
Andrea ArdizzoniAndrea Ardizzoni
Andrea Ardizzoni
CFClaudio Franceschi
Claudio Franceschi
ACAndrea Cossarizza
Andrea Cossarizza
1 November 1993 in Biochemical and Biophysical Research Communications
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Journal Article
Closed access
ACAndrea Cossarizza
Andrea Cossarizza
MBM. Baccaranicontri
M. Baccaranicontri
GKG. Kalashnikova
G. Kalashnikova
CFC. Franceschi
C. Franceschi
6 July 2020 in Nature Communications
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Journal Article
Open access
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SBSara De Biasi
Sara De Biasi
MMMarianna Meschiari
Marianna Meschiari
LGLara Gibellini
Lara Gibellini
CBCaterina Bellinazzi
Caterina Bellinazzi
RBRebecca Borella
Rebecca Borella
ACAndrea Cossarizza
Andrea Cossarizza
The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients’ T cell compartment displays several alterations involving naïve, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1+CD57+ exhausted T cells. Significant alterations exist also in several lineage-specifying transcription factors and chemokine receptors. Terminally differentiated T cells from patients proliferate less than those from healthy controls, whereas their mitochondria functionality is similar in CD4+ T cells from both groups. Patients display significant increases of proinflammatory or anti-inflammatory cytokines, including T helper type-1 and type-2 cytokines, chemokines and galectins; their lymphocytes produce more tumor necrosis factor (TNF), interferon-γ, interleukin (IL)-2 and IL-17, with the last observation implying that blocking IL-17 could provide a novel therapeutic strategy for COVID-19.
7 December 2021 in European Journal of Immunology
Verified
Journal Article
Open access
PDF file
ACAndrea Cossarizza
Andrea Cossarizza
HCHyun-Dong Chang
Hyun-Dong Chang
ARAndreas Radbruch
Andreas Radbruch
SASergio Abrignani
Sergio Abrignani
RARichard Addo
Richard Addo
JYJuhao Yang
Juhao Yang
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical samples with examples of flow cytometry applications in the context of autoimmune diseases, cancers as well as acute and chronic infectious diseases. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid. All sections are written and peer‐reviewed by leading flow cytometry experts and immunologists, making this edition an essential and state‐of‐the‐art handbook for basic and clinical researchers.