Cardiac arrhythmias are a frequent complication in the evolution of patients with congenital heart disease. Corrective surgery for these malformations is an additional predisposition to the appearance of arrhythmias. Several factors related to the patient, as well as to the therapeutic management, are involved in the etiopathogenesis of cardiac arrhythmias occurring post-operatively. The risk of arrhythmias in the immediate postoperative period is correlated with the patient’s young age and low weight at surgery. The change in heart geometry, hemodynamic stress, and post-surgical scars represent the main etiopathogenic factors that can contribute to the occurrence of cardiac arrhythmias in the population of patients with operated-on congenital heart malformations. Clinical manifestations differ depending on the duration of the arrhythmia, underlying structural defects, hemodynamic conditions, and comorbidities. The accurate diagnosis and the establishment of specific management options strongly influence the morbidity and mortality associated with arrhythmias. As such, identifying the risk factors for the occurrence of cardiac arrhythmias in the case of each patient is essential to establish a specific follow-up and management plan to improve the life expectancy and quality of life of children.

Psoriasis is a chronic skin condition that can significantly impact the quality of life of those affected. As an autoimmune disease, it can lead to itchy, painful, and scaly patches on the skin. Although various treatments, including topical creams, phototherapy, and systemic medications, are currently available, they may not always offer effective relief and can have side effects. Researchers have thus been exploring the potential benefits of non-psychoactive compounds such as CBD, found in Cannabis sativa plants, for treating psoriasis. CBD treatment may reduce inflammation, oxidative stress, itching, abnormal proliferation of keratinocytes, and may increase hydration. This review aims to provide an overview of the existing literature on the potential uses of CBD for psoriasis treatment.

Introduction: From the observation of a negative relationship between UV-B exposure and cancer rates, we hypothesized that vitamin D (VD) may play a protective role in oncogenesis. Moreover, repurposing a well-known and relatively safe drug for conditions with dismal prospects, such as pancreatic ductal adenocarcinoma (PDAC), is a tempting idea. Thus, we aimed to summarize the current knowledge regarding the role of VD in the prevention and treatment of PDAC. Methods: We conducted a systematic review of VD and PDAC using Medline-indexed studies accessed through PubMed as the primary data source. This study aimed to identify articles focusing on the role of VD as a risk and prognostic factor for PDAC, mechanistic studies evaluating the effects of VD or vitamin D analogs (VDAs) in PDAC models, and clinical trials on VDAs in PDAC. After the screening, 97 studies were included in the final manuscript. Conclusion: Even though the results from epidemiologic studies were contradictory, basic research has demonstrated that VD can act on PDAC cells either directly, inhibiting proliferation, apoptosis, EMT, migration, invasion, and stemness, or indirectly, through stromal remodeling. A better understanding of the consequences of VD-induced tumor–stroma cross-talk alterations is needed to determine whether VD/VDAs can be used to our own advantage in the treatment of PDAC.

Seasonal influenza coupled with COVID-19, infection with the virus SARS-CoV2, represents a dual challenge to the primary care. As well as this, the staff in primary health care, ambulatory centers and hospitals are intensively involved in the diagnosis, treatment and monitoring of people with the flu during the peak periods of the disease. In Romania, in primary healthcare, the diagnosis is based more on clinical criteria and not always by determining the etiology of the respiratory infection. The use of rapid tests in the diagnosis of respiratory infections has increased in the last year. Given the current increase in cases of both COVID-19 and seasonal influenza, early diagnosis is also of great importance to enable efficient use of healthcare resources in primary care. Patients with influenza and risk factors should be monitored for complications, upper respiratory infections, secondary pneumonia and acute cardio and cerebrovascular events. Additionally, vaccination should be very strong recommended in patients with chronic diseases.

Osteoporosis is a metabolic bone disorder characterized by decreased bone mass and increased risk of fracture. Most of the time, the evolution is asymptomatic, whether it is the primary form or the secondary osteoporosis. The diag­nosis should be suspected in patients in whom fac­tors favoring secondary osteoporosis are identified or in el­der­ly people or menopausal women, using the FRAX score that estimates the risk of fracture in the next 10 years. The family doctor can raise the suspicion of osteoporosis, recom­mend paraclinical investigations and he can diagnose os­teo­po­rosis, in order to initiate the treatment as early as possible, with the aim of avoiding the occurrence of fractures.