By using the intelligent edge computing technologies, a large number of computing tasks of end devices in Industrial Internet of Things (IIoT) can be offloaded to edge servers, which can effectively alleviate the burden and enhance the performance of IIoT. However, in large-scale multi-service-oriented IIoT scenarios, offloading service resources are heterogeneous and offloading requirements are mutually exclusive and time-varying, which reduce the offloading efficiency. In this paper, we propose a cloud-edge-end collaboration intelligent service computation offloading scheme based on Digital Twin (DT) driven Edge Coalition Formation (DECF) approach to improve the offloading efficiency and the total utility of edge servers, respectively. Firstly, we establish a DT model to obtain accurate digital representations of heterogeneous end devices and network state parameters in dynamic and complex IIoT scenarios. The DT model can capture time-varying requirements in a low latency manner. Secondly, we formulate two optimization problems to maximize the offloading throughput and total system utility. Finally, we convert the multiobjective optimization problems to a Stackelberg coalition game model and develop a distributed coalition formation approach to balance the two optimizing objectives. Simulation results indicate that, compared with the nearest coalition scheme and non-coalition scheme, the proposed approach achieves offloading throughput improvements of 11.5% and 148%, and enhances the overall utility by 12% and 170%, respectively.

CDR1as is a well‐identified circular RNA with regulatory roles in a variety of physiological processes. However, the effects of CDR1as on stemness of periodontal ligament stem cells (PDLSCs) and the underlying mechanisms remain unclear. In this study, we detect CDR1as in human PDLSCs, and subsequently demonstrate that CDR1as maintains PDLSC stemness. Knockdown of CDR1as decreases the expression levels of stemness‐related genes and impairs the cell's multi‐differentiation and cell migration abilities, while overexpression of CDR1as increases the expression levels of stemness‐related genes and enhances these abilities. Furthermore, our results indicate that the RNA‐binding protein hnRNPM directly interacts with CDR1as and regulates its expression in PDLSCs. In addition, we show that CDR1as promotes the expression of stemness‐related genes in PDLSCs by inhibiting miR‐7‐mediated suppression of KLF4 expression. Collectively, our results demonstrate that CDR1as participates in the molecular circuitry that regulates PDLSC stemness.

CircRNA is a novel class of noncoding RNA with closed‐loop structure. Increasing biological experiments have shown that circRNAs play an important role in many diseases by acting as a miRNA sponge to indirectly regulate the expression of miRNA target genes. Therefore, predicting associations between circRNAs and miRNAs can promote the understanding of pathogenesis of disease. In this paper, we propose a new computational method, NECMA, based on network embedding to predict potential associations between circRNAs and miRNAs. In our method, the Gaussian interaction profile (GIP) kernel similarities of circRNA and miRNA are calculated based on the known circRNA‐miRNA associations, respectively. Then, the circRNA‐miRNA association network, circRNA GIP kernel similarity network, and miRNA GIP kernel similarity network are utilized to construct the heterogeneous network. Furthermore, the network embedding algorithm is used to extract potential features of circRNA and miRNA from the heterogeneous network, respectively. Finally, the associations between circRNAs and miRNAs are predicted by using neighborhood regularization logic matrix decomposition and inner product. The performance of NECMA is evaluated by using ten‐fold cross‐validation. The results show that this method has better prediction accuracy than other state‐of‐the‐art methods.

Many Carrier Sense Multiple Access (CSMA) and Time Division Multiple Access (TDMA) based medium access control (MAC) protocols for vehicular ad hoc networks (VANETs) have been proposed recently. Contrary to the common perception that they are competitors, we argue that the underlying strategies used in these MAC protocols are complementary. Based on this insight, we design CTMAC, a MAC protocol that synthesizes existing strategies; namely, random accessing channel (used in CSMA-style protocols) and arbitral reserving channel (used in TDMA-based protocols). CTMAC swiftly changes its strategy according to the vehicle density, and its performance is better than the state-of-the-art protocols. We evaluate CTMAC using at-scale simulations. Our results show that CTMAC reduces the channel completion time and increases the network goodput by 45% for a wide range of application workloads and network settings.

The low energy adaptive clustering hierarchy (LEACH) is the classical hierarchical topology control algorithm and still widely used today in wireless sensor networks. There are some problems in LEACH such us an unreasonable selection and uneven distribution of cluster heads, not considering the residual energy of nodes, the cluster head is overloaded and there is a high energy consumption of data transmission. In this paper, a topology control algorithm with double cluster heads and multi-hop based on affinity propagation clustering (APDC-M) was proposed. In APDC-M, firstly, a cluster head election algorithm with double choices based on the affinity propagation clustering algorithm (AP) and reference node strategy (APDC) was proposed. APDC is responsible to elect the fusion cluster head for node clustering. Secondly, a forwarding cluster head is elected within each cluster. The forwarding cluster head is responsible for the data transmission in order to reduce the energy consumption of a single cluster head. Lastly, the forwarding cluster heads complete the data transmission from a cluster to the base station by the shortest path inter-cluster multi-hop mode. The comparison simulation results show that APDC-M can make the cluster head election more reasonable and the cluster head distribution more uniform, and effectively reduce the energy consumption of the cluster head nodes when transmitting data, thus prolonging the network life.

Obesity has become a widespread health problem worldwide. The body mass index (BMI) is a simple and reliable index based on weight and height that is commonly used to identify and classify adults as underweight, normal, overweight (pre-obesity), or obese. In this paper, we propose a hybrid deep neural network for predicting the BMI of smartphone users, based only on the characteristics of body movement captured by the smartphone’s built-in motion sensors without any other sensitive data. The proposed deep learning model consists of four major modules: a transformation module for data preprocessing, a convolution module for extracting spatial features, a long short-term memory (LSTM) module for exploring temporal dependency, and a fully connected module for regression. We define motion entropy (MEn), which is a measure of the regularity and complexity of the motion sensor, and propose a novel MEn-based filtering strategy to select parts of sensor data that met certain thresholds for training the model. We evaluate this model using two public datasets in comparison with baseline conventional feature-based methods using leave-one-subject-out (LOSO) cross-validation. Experimental results show that the proposed model with the MEn-based filtering strategy outperforms the baseline approaches significantly. The results also show that jogging may be a more suitable activity of daily living (ADL) for BMI prediction than walking and walking upstairs. We believe that the conclusions of this study will help to develop a long-term remote health monitoring system.