This paper presents a temperature study of cellular spheroids of the line MCF-07 under a hyperthermia (HT) treatment. A 3D printed culture plate embedded with optical fiber Bragg grating (FBG) sensors was designed to perform real-time temperature measurements of the spheroids. The proposed culture plate preserves the fiber sensors' integrity and functionality while remaining immune to the high electromagnetic interference scenario. A custom microwave applicator was designed to eliminate direct contact between the heating element and the samples, while considering the culture plate material's permittivity to ensure efficient heating. The heating setup maintains the samples' temperature within the HT range, which is crucial for predicting treatment outcomes. The sensors embedded in the designed culture plate achieved an accuracy within 0.31 ${}^\mathrm{C}$ . Initial observations of the temperature effects on spheroids are discussed, highlighting the potential of this approach to understand how temperature variations within the HT range affect cell cultures.
The validation and construction of a setup for the measurement of changes in temperature product of the exposition of biological tissue substitute material (phantom) to microwave radiation is presented, in this were used optical Fiber Bragg Gratings FBGs sensors to validate the hypotesis that their presence in the phantom does not disturb the electromagnetic fields a nd f or t hat r eason t hey a re s uitable t o p erform m easurements of temperature in real time. This is a key factor in hyperthermia treatments were many of its benefits d epends i n a c ritical way o n t he a bility t o m easure h igh t emperatures specially when the heating is carried out via irradiation of microwave energy. From these results a linear relation between the temperature reached and the irradiation time is obtained. This is a good departure point to consider other factors in the irradiation instruments that ensure temperature changes that are not harmful to the human body.
Design and characterization of 3D spheroids culture plates with embedded FBG sensors for temperature measurements during induced hyperthermia using an RF source, are presented. Additionally, initial observations of the effects on the spheroids are discussed.
The Amazon rainforest plays a crucial role in stabilizing the global climate and is vital for preserving biodiversity, wildlife, and indigenous cultures. Despite efforts to protect the Amazon rainforest, deforestation, wildlife trafficking, mining, oil exploitation and other extractive industries continue to threaten the region. Remote Monitoring Systems (RMS) are necessary to effectively detect and analyze these threats. This systematic review of technological initiatives to protect natural resources demonstrates the importance of technology in conservation and the need for further research and development. This article identifies technologies used worldwide for conservation efforts and highlights the challenges in developing an RMS for the Amazon region, such as harsh environmental conditions and limited infrastructure. The timely detection of threats could help authorities take corrective actions and prevent further environmental effects on the Amazon rainforest.
In this work we propose the use of Optical Fiber Bragg Gratings (FBGs), due to their electromagnetic immunity, to monitor the temperature in tumor cell cultures exposed to microwave radiation for their application in hyperthermia treatments.