George Tsokos

Dr. George Tsokos

orcid

Research Focus & Metrics

Academic Career Length

30Years (1997-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 December 2011 in New England Journal of Medicine
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Journal Article
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GTGeorge Tsokos
George Tsokos
The author reviews environmental, genetic, epigenetic, and hormonal factors in systemic lupus erythematosus, its diverse organ manifestations, and the myriad immune abnormalities that characterize this autodestructive disease, which mainly affects women of childbearing age.

15 December 2008 in The Journal of Immunology
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Journal Article
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JCJosé C. Crispín
José C. Crispín
MOMohamed Oukka
Mohamed Oukka
GBGeorge Bayliss
George Bayliss
RCRobert A Cohen
Robert A Cohen
CBChristine A Van Beek
Christine A Van Beek
GTGeorge Tsokos
George Tsokos
Double negative (DN) T cells are expanded in patients with systemic lupus erythematosus (SLE) and stimulate autoantibody production as efficiently as CD4+ T cells. In this study, we demonstrate that DN T cells from patients with SLE produce significant amounts of IL-17 and IFN-γ, and expand when stimulated in vitro with an anti-CD3 Ab in the presence of accessory cells. Furthermore, IL-17+ and DN T cells are found in kidney biopsies of patients with lupus nephritis. Our findings establish that DN T cells produce the inflammatory cytokines IL-17 and IFN-γ, and suggest that they contribute to the pathogenesis of kidney damage in patients with SLE.

4 May 2020 in Nature Immunology
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Journal Article
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GTGeorge Tsokos
George Tsokos

12 August 2021 in Nature Immunology
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Journal Article
Closed access
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PLPengchong Li
Pengchong Li
MJMengdi Jiang
Mengdi Jiang
KLKetian Li
Ketian Li
HLHao Li
Hao Li
YZYangzhong Zhou
Yangzhong Zhou
XZXuan Zhang
Xuan Zhang

1 July 2017 in Trends in Molecular Medicine
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Journal Article
Closed access
VMVaishali R. Moulton
Vaishali R. Moulton
AFAbel Suarez Fueyo
Abel Suarez Fueyo
EMEsra Meidan
Esra Meidan
HLHao Li
Hao Li
MMMasayuki Mizui
Masayuki Mizui
GTGeorge Tsokos
George Tsokos

27 January 2023 in Nature Reviews Immunology
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Journal Article
Closed access
PDF file
MSMarc Scherlinger
Marc Scherlinger
CRChristophe Richez
Christophe Richez
GTGeorge Tsokos
George Tsokos
EBEric Boilard
Eric Boilard
PBPatrick Blanco
Patrick Blanco