Production of crude oil from matured oil reservoirs has major issues due to decreased oil recovery with water channeling; however, the low-salinity water flooding technique is more commonly used to maximize recovery of the remaining oil. In this study, we demonstrated a new hybridization technique of combining low-salinity water and nanofluids; this was achieved by using experiments such as contact angle measurement with water of different salinity levels and nanofluid concentrations, core displacement, and NMR (nuclear magnetic resonance) between low-/high-permeability rock. The trial results demonstrated that the test with KCl-1+NF outperformed those with other compositions by changing the original contact angle from 112.50° to 53.3° and increasing formation production up to 15 cc. In addition, we saw that when 2 PV of KCl-1+NF was injected at a rate of 5 mL/min, the middle pores’ water saturation dropped quickly to 73% and then steadily stabilized in the middle and late stages. Regarding the novel application of the hybridization technique, the insights presented in this paper serve as a helpful resource for future studies in this field.