Metabolomics is an advanced technology, still under development, with multiple research applications, especially in the field of health. Individual metabolic profiles, the functionality of the body, as well as its interaction with the environment, can be established using this technology. The body’s response to various external factors, including the food consumed and the nutrients it contains, has increased researchers’ interest in nutrimetabolomics. Establishing correlations between diet and the occurrence of various diseases, or even the development of personalized nutrition plans, could contribute to advances in precision medicine. The interdependence between humans, animals, and the environment is of particular importance today, with the dramatic emergence and spread of zoonotic diseases, food, water and soil contamination, and the degradation of resources and habitats. All these events have led to an increase in risk factors for functional diseases, burdening global health. Thus, this study aimed to highlight the importance of metabolomics, and, in particular, nutrimetabolomics, as a technical solution for a holistic, collaborative, and precise approach for the advancement of the One Health strategy.

Bee products have a millennia-old tradition in human apitherapy, thanks to their numerous curative properties. The aim of this study was to perform a physicochemical characterization, including the percentage of water content, dry matter, pH, acidity, impurity content, protein, ash, and macro and micro minerals, and to evaluate the antioxidant activity of apiculture products, including apilarnil, royal jelly, and propolis. Samples were collected from our apiary in the Banat region of Romania in 2022 as well as from the market. Apilarnil and royal jelly were analyzed in pure and freeze-dried form, and propolis in pure and tincture form. Our results show that there is a large variability in the chemical composition and antioxidant activity of the three bee products studied, depending on the form of presentation and source of origin. In the case of commercial bee products, the best results were obtained in terms of chemical composition, including the content of macro and micro nutrients. All the samples analyzed showed acidity, pH, and impurity content values within the limits allowed by the quality standards. Apilarnil from our own apiary recorded the highest values for antioxidant activity, followed by propolis tincture and fresh propolis from own apiary.

Wheat (Triticum aestivum L.) is the basic cereal in human and animal nutrition. Every month, wheat is harvested somewhere in the world. In Romania, a country with a temperate-continental climate, the wheat is harvested between June and July, while the sowing is carried out between September and October. Climatic and meteorological factors during these periods can influence the nutritional quality of wheat. The aim of this study was to analyse the influence of annual average temperature and the amount of precipitate on the chemical composition and on the value of metabolizable energy of the wheat, respectively. The climatic and meteorological data used in this study come from NMA database. Were analysed the periods September 2017 - July 2018 (period 1, noted with 2018 - the year of harvesting) and September 2018 - July 2019 (period 2, noted with 2019 - the year of harvesting), respectively. For the chemical analysis, the NIR (Near InfraRed spectroscopy) method was used. The calculation of metabolizable energy was performed based on the ATWATER system, a system applicable to both human and animal nutrition. The statistical analysis of the climatic and meteorological data showed that the annual average temperature for period 1 was lower compared to the temperatures of period 2. Also, the precipitations were more abundant in period 1 compared to period 2. There were no significant statistical differences for any of the climatic and meteorological factors assayed during the analyzed periods. Following the statistical correlations between the nutrients studied by chemical analysis, for those 2 periods, significant differences were observed (p <0.001). The humidity of wheat grains harvested in 2018 was higher (average = 13.03%) compared to that of grains harvested in 2019 (average = 10.72%). The protein content was lower in 2018 (average = 10.02%) than in 2019 (average = 11.04%); and similar results were obtained for the fibre content (average 2018 = 2.17%; average 2019 = 2.96%). Also, the value of metabolizable energy was lower for wheat harvested in 2018 (average = 3517.90 kcal/kg) compared to 2019 (average = 3611.04 kcal/kg). In conclusion, the results of this study highlight the influence of temperature and precipitation on the chemical composition of wheat, thus having a direct impact on the nutritional quality of this grain for human and animal nutrition.

Sheep nutrition is of paramount importance for ensuring sustainable sheep production, regardless of whether it follows traditional or precision methods. Optimal nutrition not only contributes to the well-being and productivity of sheep but also mitigates environmental consequences. Both traditional and precision production systems can adopt responsible management practices to enhance sustainability. These practices encompass maximizing pasture utilization, reducing dependency on synthetic inputs, minimizing waste generation, and implementing efficient feeding strategies. By giving due consideration to the nutritional requirements of sheep and their ecological footprint, sustainable sheep production can be successfully attained across various production systems. It is essential to strike a balance between meeting the nutritional needs of sheep and minimizing environmental impacts to foster a sustainable future for sheep farming.

Metabolomics is an advanced technology, still under development, with multiple research applications, especially in the field of health. Individual metabolic profiles, the functionality of the body, as well as its interaction with the environment can be established using this technology. The body's response to various external factors, including the food consumed and the nutrients it contains, has increased researchers' interest in nutrimetabolomics. Establishing correlations between diet and the occurrence of various diseases or even the development of personalized nutrition plans, could contribute to advances in precision medicine. The interdependence between humans, animals and the environment are of particular importance today, with the dramatic emergence and spread of zoonotic diseases, food, water and soil contamination, and the degradation of resources and habitats. All these events have led to an increase of risk factors for functional diseases, burdening global health. Thus, this study aimed to highlight the importance of metabolomics, in particular of nutrimetabolomics, as a technical solution for a holistic, collaborative, and precise approach for the advancement of the One Health strategy.