Economic transformation is an effective strategy for resource-based regions to avoid the “resource curse”. In China’s high-quality development stage, using new-generation IT to guide economic structure adjustment, industrial upgrading, and technological innovation is of great practical significance. It also helps regions achieve ecological and high-quality development. Based on SDM, this paper takes smart eco-innovation as the driving force for high-quality transformation. The system constructed is built from five aspects: innovation, coordination, green development, openness, and sharing. Additionally, based on the interrelationships among the subsystems, this paper constructs causal loop diagrams and flow diagrams. Taking Daqing City in China as an example, it conducts a scenario simulation of high-quality transformation driven by smart eco-innovation. The finding shows that the combined policy effects of smart eco-innovation are the most significant for the high-quality transformation of resource-based regions. This study provides a new perspective. It explores the transformation of resource-based regions driven by a “smart eco-style” approach and provides references for such regions in China.