This page has only limited features, please log in for full access.
The neurobiology of Parkinson’s disease and its progression has been investigated during the last few decades. Braak et al. proposed neuropathological stages of this disease based on the recognizable topographical extent of Lewy body lesions. This pathological process involves specific brain areas with an ascending course from the brain stem to the cortex. Post-mortem studies are of importance to better understand not only the progression of motor symptoms, but also the involvement of other domains, including cognition and behavior. The correlation between the neuropathological expansion of the disease and the clinical phases remains demanding. Neuroimaging, including magnetic resonance imaging (MRI), positron emission tomography (PET), and single photon emission computed tomography (SPECT), could help to bridge this existing gap by providing in vivo evidence of the extension of the disorders. In the last decade, we observed an overabundance of reports regarding the sensitivity of neuroimaging techniques. All these studies were aimed at improving the accuracy of Parkinson’s disease (PD) diagnosis and discriminating it from other causes of parkinsonism. In this review, we look at the recent literature concerning PD and address the new frontier of diagnostic accuracy in terms of identification of early stages of the disease and conventional neuroimaging techniques that, in vivo, are capable of photographing the basal ganglia network and its cerebral connections.
Fulvio Lauretani; Yari Longobucco; Giulia Ravazzoni; Elena Gallini; Marco Salvi; Marcello Maggio. Imaging the Functional Neuroanatomy of Parkinson’s Disease: Clinical Applications and Future Directions. International Journal of Environmental Research and Public Health 2021, 18, 2356 .
AMA StyleFulvio Lauretani, Yari Longobucco, Giulia Ravazzoni, Elena Gallini, Marco Salvi, Marcello Maggio. Imaging the Functional Neuroanatomy of Parkinson’s Disease: Clinical Applications and Future Directions. International Journal of Environmental Research and Public Health. 2021; 18 (5):2356.
Chicago/Turabian StyleFulvio Lauretani; Yari Longobucco; Giulia Ravazzoni; Elena Gallini; Marco Salvi; Marcello Maggio. 2021. "Imaging the Functional Neuroanatomy of Parkinson’s Disease: Clinical Applications and Future Directions." International Journal of Environmental Research and Public Health 18, no. 5: 2356.
The gut microbiota could influence the pathophysiology of age-related sarcopenia through multiple mechanisms implying modulation of chronic inflammation and anabolic resistance. The aim of this study was to compare the fecal microbiota composition and functionality, assessed by shotgun metagenomics sequencing, between two groups of elderly outpatients, differing only for the presence of primary sarcopenia. Five sarcopenic elderly subjects and twelve non-sarcopenic controls, classified according to lower limb function and bioimpedance-derived skeletal muscle index, provided a stool sample, which was analyzed with shotgun metagenomics approaches, to determine the overall microbiota composition, the representation of bacteria at the species level, and the prediction of bacterial genes involved in functional metabolic pathways. Sarcopenic subjects displayed different fecal microbiota compositions at the species level, with significant depletion of two species known for their metabolic capacity of producing short-chain fatty acids (SCFAs), Faecalibacterium prausnitzii and Roseburia inulinivorans, and of Alistipes shahii. Additionally, their fecal metagenome had different representation of genes belonging to 108 metabolic pathways, namely, depletion of genes involved in SCFA synthesis, carotenoid and isoflavone biotransformation, and amino acid interconversion. These results support the hypothesis of an association between microbiota and sarcopenia, indicating novel possible mediators, whose clinical relevance should be investigated in future studies.
Andrea Ticinesi; Leonardo Mancabelli; Sara Tagliaferri; Antonio Nouvenne; Christian Milani; Daniele Del Rio; Fulvio Lauretani; Marcello Giuseppe Maggio; Marco Ventura; Tiziana Meschi. The Gut–Muscle Axis in Older Subjects with Low Muscle Mass and Performance: A Proof of Concept Study Exploring Fecal Microbiota Composition and Function with Shotgun Metagenomics Sequencing. International Journal of Molecular Sciences 2020, 21, 8946 .
AMA StyleAndrea Ticinesi, Leonardo Mancabelli, Sara Tagliaferri, Antonio Nouvenne, Christian Milani, Daniele Del Rio, Fulvio Lauretani, Marcello Giuseppe Maggio, Marco Ventura, Tiziana Meschi. The Gut–Muscle Axis in Older Subjects with Low Muscle Mass and Performance: A Proof of Concept Study Exploring Fecal Microbiota Composition and Function with Shotgun Metagenomics Sequencing. International Journal of Molecular Sciences. 2020; 21 (23):8946.
Chicago/Turabian StyleAndrea Ticinesi; Leonardo Mancabelli; Sara Tagliaferri; Antonio Nouvenne; Christian Milani; Daniele Del Rio; Fulvio Lauretani; Marcello Giuseppe Maggio; Marco Ventura; Tiziana Meschi. 2020. "The Gut–Muscle Axis in Older Subjects with Low Muscle Mass and Performance: A Proof of Concept Study Exploring Fecal Microbiota Composition and Function with Shotgun Metagenomics Sequencing." International Journal of Molecular Sciences 21, no. 23: 8946.
Background The association between amyloid deposition and cognitive, behavioral and physical performance in mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) has been poorly investigated, especially in older persons. Methods We studied the in vivo correlation between the amyloid deposition at Positron Emission Tomography (amyloid-PET) and the presence of memory loss, reduced executive function, neuropsychiatric symptoms and physical performance in older persons with MCI. Amyloid-PET was performed with 18F-flutemetamol and quantitatively analyzed. Results We evaluated 48 subjects, 21 men and 27 women. We performed in each patient a comprehensive geriatric assessment (CGA) including Mini Mental State Examination (MMSE), Clock Drawing Test (CDT), Activity Daily Living (ADL), Instrumental Activity of Daily Living (IADL), Neuropsychiatric inventory (NPI) questionnaire, 15 Geriatric Depression Scale (GDS), Short Physical Performance Battery (SPPB) and Hand Grip strength. Then, each patient underwent amyloid-PET. Mean age of the enrolled subjects was 74.6 ± 7.8 years. All of these subjects showed preserved cognitive function at MMSE > 24, while 29 of 48 subjects (61.0%) had altered CDT. Mean NPI score was 6.9 ± 5.9. The mean value of SPPB score was 9.0 ± 2.6, while the average muscle strength of the upper extremities measured by hand grip was 25.6 ± 7.7 Kg. CT/MRI images showed cortical atrophic changes in 26 of the 48 examined subjects (54.0%), while cerebrovascular modifications were present in 31 subjects (64.5%). Pathological burden of amyloid deposits was detected in 25 of 48 (52.0%) patients with a mean value of global z-score of 2.8 (subjects defined as MCI due to AD). After stratifying subjects in subclasses of clinical alterations, more probability of pathological amyloid deposition was found in subjects with impaired CDT and higher NPI score (O.R. = 3.45 [1.01–11.2], p = 0.04), with both impaired CDT and low physical performance (O.R. = 5.80 [1.04–32.2], p = 0.04), with altered CDT and high NPI score (O.R. = 7.98 [1.38–46.0], p = 0.02), and finally in those subjects with altered CDT, high NPI and low physical performance (O.R. = 5.80 [1.05–32.2], p = 0.04). Conclusion Our findings support the recent hypothesis that amyloid deposition could be associated with multiple cerebral dysfunction, mainly affecting executive, behavioral and motor abilities.
Fulvio Lauretani; Livia Ruffini; Maura Scarlattei; Marcello Maggio. Relationship between comprehensive geriatric assessment and amyloid PET in older persons with MCI. BMC Geriatrics 2020, 20, 1 -9.
AMA StyleFulvio Lauretani, Livia Ruffini, Maura Scarlattei, Marcello Maggio. Relationship between comprehensive geriatric assessment and amyloid PET in older persons with MCI. BMC Geriatrics. 2020; 20 (1):1-9.
Chicago/Turabian StyleFulvio Lauretani; Livia Ruffini; Maura Scarlattei; Marcello Maggio. 2020. "Relationship between comprehensive geriatric assessment and amyloid PET in older persons with MCI." BMC Geriatrics 20, no. 1: 1-9.
Background. The association between amyloid deposition and cognitive, behavioral and physical performance in mild cognitive impairment (MCI) due to Alzheimer's disease (AD) has been poorly investigated, especially in older persons. Methods. We studied the in vivo correlation between the amyloid deposition at Positron Emission Tomography (amyloid-PET) and the presence of memory loss, reduced executive function, physical performance and neuropsychiatric symptoms in older persons with MCI. Amyloid-PET was performed with 18F-flutemetamol and quantitatively analyzed. Results. We evaluated 48 subjects, 21 men and 27 women. We performed in each patient a comprehensive geriatric assessment (CGA) including Mini Mental State Examination (MMSE), Clock Drawing Test (CDT), Activity Daily Living (ADL), Instrumental Activity of Daily Living (IADL), Neuropsychiatric inventory (NPI) questionnaire, 15 Geriatric Depression Scale (GDS), Short Physical Performance Battery (SPPB) and Hand Grip strength. Then, each patient underwent amyloid-PET. Mean age of the enrolled subjects was 74.6 ± 7.8 years. All of these subjects showed preserved cognitive function at MMSE > 24, while 29 of 48 subjects (61.0 %) had altered CDT. Mean NPI score was 6.9 ± 5.9. The mean value of SPPB score was 9.0 ± 2.6, while the average muscle strength of the upper extremities measured by hand grip was 25.6±7.7 Kg. CT/MRI images showed cortical atrophic changes in 26 of the 48 examined subjects (54.0 %), while cerebrovascular modifications were present in 31 subjects (64.5 %). Pathological burden of amyloid deposits was detected in 25 of 48 (52.0 %) patients with a mean value of global z-score of 2.8 (subjects defined as MCI due to AD). After stratifying subjects in subclasses of clinical alterations, more probability of pathological amyloid deposition was found in subjects with impaired CDT and higher NPI score (O.R.= 3.45 [1.01-11.2], p=0.04), with both impaired CDT and low physical performance (O.R.= 5.80 [1.04-32.2], p=0.04), with altered CDT and high NPI score (O.R.=7.98 [1.38-46.0], p=0.02), and finally in those subjects with altered CDT, high NPI and low physical performance (O.R.= 5.80 [1.05-32.2], p=0.04). Conclusion. Our findings support the recent hypothesis that amyloid deposition could be associated with multiple cerebral dysfunction, mainly affecting executive, behavioral and motor abilities.
Fulvio Lauretani; Livia Ruffini; Maura Scarlattei; Marcello Maggio. Relationship between comprehensive geriatric assessment and amyloid PET in older persons with MCI. 2020, 1 .
AMA StyleFulvio Lauretani, Livia Ruffini, Maura Scarlattei, Marcello Maggio. Relationship between comprehensive geriatric assessment and amyloid PET in older persons with MCI. . 2020; ():1.
Chicago/Turabian StyleFulvio Lauretani; Livia Ruffini; Maura Scarlattei; Marcello Maggio. 2020. "Relationship between comprehensive geriatric assessment and amyloid PET in older persons with MCI." , no. : 1.
Covid-19 infection is a multisystem disease more frequent in older individuals, especially in those with multiple chronic diseases. This multimorbid and frail population requires attention and a personalized comprehensive assessment in order to avoid the occurrence of adverse outcomes. As other diseases, the COVID-19 presentation in older patients is often atypical with less severe and unspecific symptoms. These subjects both at home and during hospitalization suffer isolation and the lack of support of caregivers. The geriatric care in COVID-19 wards is often missing. The application of additional instruments would be necessary to facilitate and personalize the clinical approach, not only based on diseases but also on functional status. This narrative review starts from diagnostic evaluation, continues with adapted pharmacologic treatment and ends with the recovery phase targeting the nutrition and physical exercise. We developed a check-list of respiratory, gastro-intestinal and other less-specific symptoms, summarized in a table and easily to be filled-up by patients, nurses and general practitioners. As second step, we reported the clinical phases of this disease. Far to be considered just viral infective and respiratory, this disease is also an inflammatory and thrombotic condition with frequent bacterial over-infection. We finally considered timing and selection of treatment, which depend on the disease phase, co-administration of other drugs and require the monitoring of renal, liver and cardiac function. This underlines the role of age not just as a limitation, but also an opportunity to increase the quality and the appropriateness of multidisciplinary and multidimensional intervention in this population. (www.actabiomedica.it)
Fulvio Lauretani; Giulia Ravazzoni; Maria Federica Roberti; Yari Longobucco; Elisa Adorni; Margherita Grossi; Aurelio De Iorio; Umberto La Porta; Chiara Fazio; Elena Gallini; Raffaele Federici; Marco Salvi; Erika Ciarrocchi; Francesca Rossi; Marina Bergamin; Giacomo Bussolati; Ilaria Grieco; Federica Broccoli; Irene Zucchini; Giuseppe Ielo; Simonetta Morganti; Andrea Artoni; Arianna Arisi; Sara Tagliaferri; Marcello Maggio. Assessment and treatment of older individuals with COVID-19 multi-system disease: clinical and ethical implications. Acta bio-medica : Atenei Parmensis 2020, 91, 150 -168.
AMA StyleFulvio Lauretani, Giulia Ravazzoni, Maria Federica Roberti, Yari Longobucco, Elisa Adorni, Margherita Grossi, Aurelio De Iorio, Umberto La Porta, Chiara Fazio, Elena Gallini, Raffaele Federici, Marco Salvi, Erika Ciarrocchi, Francesca Rossi, Marina Bergamin, Giacomo Bussolati, Ilaria Grieco, Federica Broccoli, Irene Zucchini, Giuseppe Ielo, Simonetta Morganti, Andrea Artoni, Arianna Arisi, Sara Tagliaferri, Marcello Maggio. Assessment and treatment of older individuals with COVID-19 multi-system disease: clinical and ethical implications. Acta bio-medica : Atenei Parmensis. 2020; 91 (2):150-168.
Chicago/Turabian StyleFulvio Lauretani; Giulia Ravazzoni; Maria Federica Roberti; Yari Longobucco; Elisa Adorni; Margherita Grossi; Aurelio De Iorio; Umberto La Porta; Chiara Fazio; Elena Gallini; Raffaele Federici; Marco Salvi; Erika Ciarrocchi; Francesca Rossi; Marina Bergamin; Giacomo Bussolati; Ilaria Grieco; Federica Broccoli; Irene Zucchini; Giuseppe Ielo; Simonetta Morganti; Andrea Artoni; Arianna Arisi; Sara Tagliaferri; Marcello Maggio. 2020. "Assessment and treatment of older individuals with COVID-19 multi-system disease: clinical and ethical implications." Acta bio-medica : Atenei Parmensis 91, no. 2: 150-168.
To investigate the current evidence on the use of point-of-care chest ultrasonography in older patients and geriatric settings and present the current state of the art of chest ultrasound applications. Special article based on a literature review with narrative analyses and expert clinical knowledge. All studies performed in a geriatric setting were included. Observational and intervention studies and meta-analyses including participants aged ≥70 years were also considered, even if not specifically focused on a geriatric setting. Data on participant characteristics, diagnostic accuracy of chest ultrasonography, and outcomes were collected for each considered study. Data were analyzed and discussed with a particular focus on the possible applications and advantages of chest ultrasonography in geriatric medicine, underlining the possible areas of future research. We found only 5 studies on the diagnostic accuracy and prognostic relevance of chest ultrasonography in geriatrics. However, several studies performed in emergency departments, intensive care units, and internal medicine wards included a large number of participants ≥70 years old; they suggest that chest ultrasonography may represent a valid aid to the diagnostics of acute dyspnea, pneumonia, acute heart failure, pneumothorax, and pleural diseases, with an accuracy in some cases superior to standard x-rays, especially when mobility limitation is present. Diaphragm ultrasonography may also represent a valid tool to guide mechanical ventilation weaning in older patients with acute respiratory failure. Chest ultrasonography may represent a valid bedside diagnostic aid to the management of acute respiratory diseases in older patients. However, specific evidence is lacking for geriatric patients. Future research will need to focus on defining the reference standards and the diagnostic accuracy for older patients with frailty and multimorbidity, cost-efficacy and cost-effectiveness of the technique, its impact for clinical outcomes, and role for follow-up in the post-acute care.
Andrea Ticinesi; Simone Scarlata; Antonio Nouvenne; Fulvio Lauretani; Raffaele Antonelli Incalzi; Andrea Ungar. The Geriatric Patient: The Ideal One for Chest Ultrasonography? A Review From the Chest Ultrasound in the Elderly Study Group (GRETA) of the Italian Society of Gerontology and Geriatrics (SIGG). Journal of the American Medical Directors Association 2020, 21, 447 -454.e6.
AMA StyleAndrea Ticinesi, Simone Scarlata, Antonio Nouvenne, Fulvio Lauretani, Raffaele Antonelli Incalzi, Andrea Ungar. The Geriatric Patient: The Ideal One for Chest Ultrasonography? A Review From the Chest Ultrasound in the Elderly Study Group (GRETA) of the Italian Society of Gerontology and Geriatrics (SIGG). Journal of the American Medical Directors Association. 2020; 21 (4):447-454.e6.
Chicago/Turabian StyleAndrea Ticinesi; Simone Scarlata; Antonio Nouvenne; Fulvio Lauretani; Raffaele Antonelli Incalzi; Andrea Ungar. 2020. "The Geriatric Patient: The Ideal One for Chest Ultrasonography? A Review From the Chest Ultrasound in the Elderly Study Group (GRETA) of the Italian Society of Gerontology and Geriatrics (SIGG)." Journal of the American Medical Directors Association 21, no. 4: 447-454.e6.
The prognostic value of quick Sepsis-related Organ Failure Assessment (qSOFA) score in geriatric patients is uncertain. We aimed to compare qSOFA vs. Systemic Inflammatory Response Syndrome (SIRS) criteria for mortality prediction in older multimorbid subjects, admitted for suspected sepsis in a geriatric ward. We prospectively enrolled 272 patients (aged 83.7 ± 7.4). At admission, qSOFA and SIRS scores were calculated. Mortality was assessed during hospital stay and three months after discharge. The predictive capacity of qSOFA and SIRS was assessed by calculating the Area Under the Receiver Operating Characteristic Curve (AUROC), through pairwise AUROC comparison, and multivariable logistic regression analysis. Both qSOFA and SIRS exhibited a poor prognostic performance (AUROCs 0.676, 95% CI 0.609–0.738, and 0.626, 95% CI 0.558–0.691 for in-hospital mortality; 0.684, 95% CI 0.614–0.748, and 0.596, 95% CI 0.558–0.691 for pooled three-month mortality, respectively). The predictive capacity of qSOFA showed no difference to that of SIRS for in-hospital mortality (difference between AUROCs 0.05, 95% CI −0.05 to 0.14, p = 0.31), but was superior for pooled three-month mortality (difference between AUROCs 0.09, 95% CI 0.01–0.17, p = 0.029). Multivariable logistic regression analysis, accounting for possible confounders, including frailty, showed that both scores were not associated with in-hospital mortality, although qSOFA, unlike SIRS, was associated with pooled three-month mortality. In conclusion, neither qSOFA nor SIRS at admission were strong predictors of mortality in a geriatric acute-care setting. Traditional geriatric measures of frailty may be more useful for predicting adverse outcomes in this setting.
Davide Bastoni; Andrea Ticinesi; Fulvio Lauretani; Simone Calamai; Maria Letizia Catalano; Pamela Catania; Martina Cecchia; Nicoletta Cerundolo; Claudia Galluzzo; Manuela Giovini; Giulia Mori; Marco Davìd Zani; Antonio Nouvenne; Tiziana Meschi. Application of The Sepsis-3 Consensus Criteria in a Geriatric Acute Care Unit: A Prospective Study. Journal of Clinical Medicine 2019, 8, 359 .
AMA StyleDavide Bastoni, Andrea Ticinesi, Fulvio Lauretani, Simone Calamai, Maria Letizia Catalano, Pamela Catania, Martina Cecchia, Nicoletta Cerundolo, Claudia Galluzzo, Manuela Giovini, Giulia Mori, Marco Davìd Zani, Antonio Nouvenne, Tiziana Meschi. Application of The Sepsis-3 Consensus Criteria in a Geriatric Acute Care Unit: A Prospective Study. Journal of Clinical Medicine. 2019; 8 (3):359.
Chicago/Turabian StyleDavide Bastoni; Andrea Ticinesi; Fulvio Lauretani; Simone Calamai; Maria Letizia Catalano; Pamela Catania; Martina Cecchia; Nicoletta Cerundolo; Claudia Galluzzo; Manuela Giovini; Giulia Mori; Marco Davìd Zani; Antonio Nouvenne; Tiziana Meschi. 2019. "Application of The Sepsis-3 Consensus Criteria in a Geriatric Acute Care Unit: A Prospective Study." Journal of Clinical Medicine 8, no. 3: 359.
In older patients with acute illness, a condition of “hospital-dependence” may arise: patients get adapted to the hospital care and, once discharged, may experience health status decline, requiring repeated readmissions despite appropriate treatments. The objective of this case-series study was to describe the characteristics of 118 patients (72 F) aged ≥75 (mean 83.7 ± 4.9) who were urgently admitted to our institution at least 4 times in 2015. For each patient and admission, data on multimorbidity (Cumulative Illness Rating Scale Comorbidity Score and Severity Index), frailty (Rockwood Clinical Frailty Scale), functional dependence, functional status, polypharmacy, length of stay and interval between admissions were extrapolated from clinical records. Mortality during the years 2015 and 2016 was assessed on the institutional database. At the first admission, patients had a high burden of polypharmacy (median number of drugs 8.5, IQR 6–11) and multimorbidity (Comorbidity Score 15.8 ± 4.1, Severity Index 2.9 ± 1.1). However, most (55.5%) were fit or pre-frail according to Clinical Frailty Scale (score 1–4). At multivariate models, Severity Index was significantly correlated with the length of stay (β ± SE 2.23 ± 0.89, p = .01) and readmission interval (β ± SE -22.49 ± 9.27, p = .02). Significantly increasing trends of multimorbidity and disability occurred across admissions. By the end of 2016, 66% of patients had died. Frailty (RR 2.005, 95%CI 1.054–3.814, p = .007) and cancer were the only predictors of mortality. Hospital-dependent patients had severe multimorbidity, but exhibited an unexpectedly low prevalence of frailty/disability at baseline, though increasing across admissions. Trends of frailty and multimorbidity are paramount for profiling the hospital-dependence risk.
Andrea Ticinesi; Antonio Nouvenne; Beatrice Prati; Fulvio Lauretani; Ilaria Morelli; Claudio Tana; Massimo Fabi; Tiziana Meschi. Profiling the hospital-dependent patient in a large academic hospital: Observational study. European Journal of Internal Medicine 2019, 64, 41 -47.
AMA StyleAndrea Ticinesi, Antonio Nouvenne, Beatrice Prati, Fulvio Lauretani, Ilaria Morelli, Claudio Tana, Massimo Fabi, Tiziana Meschi. Profiling the hospital-dependent patient in a large academic hospital: Observational study. European Journal of Internal Medicine. 2019; 64 ():41-47.
Chicago/Turabian StyleAndrea Ticinesi; Antonio Nouvenne; Beatrice Prati; Fulvio Lauretani; Ilaria Morelli; Claudio Tana; Massimo Fabi; Tiziana Meschi. 2019. "Profiling the hospital-dependent patient in a large academic hospital: Observational study." European Journal of Internal Medicine 64, no. : 41-47.
The assistance to older community-dwellers provided by family caregivers is crucial for the maintenance of an acceptable quality of life, especially when dementia is present. The caregiver burden may be extremely high, but few data are available on what patient domains mainly affect the caregiver. The aim of this cross-sectional study, performed in older outpatients, was to examine the impact of cognitive, physical and nutritional status of elderly community-dwellers on the caregiver burden, as evaluated by the Caregiver Burden Inventory (CBI). A group of 406 elderly outpatients (161 M, 245 F, mean age of 83.20 ± 6.40) was enrolled. A significant correlation was observed between Mini Nutritional Assessment Instrument-Short Form (MNA-SF) and CBI (r = −0.34; p < 0.001), suggesting that a poor nutritional status is significantly associated with the caregiver burden. There was also a significant correlation between CBI and Short Physical Performance Battery score (r = −0.29; p < 0.001), hand grip strength (r = −0.25; p < 0.001), Mini-Mental State Examination score (r = −0.39; p < 0.001), Geriatric Depression Scale (r = 0.23; p < 0.001), Body Mass Index (BMI) (r = 0.01; p = 0.03), Activities of Daily Living and Instrumental Activities of Daily Living (ADL/IADL) (r = −0.61 and −0.62, respectively; p < 0.001), and with the 4-m walking speed (r = −0.42; p < 0.001). In the multivariate analysis, only the relationships of the CBI (in particular the physical subcomponent) with ADL, IADL and MNA-SF remained statistically significant (β ± SE −0.89 ± 0.20, p < 0.001; −0.58 ± 0.15, p < 0.001 and −0.25 ± 0.11, p = 0.02, respectively). The relationship between CBI and BMI remained statistically significant only for the physical subcomponent (β ± SE 0.14 ± 0.05; p = 0.006). Thus, in this study, we confirmed that the impairment in the activities of daily living is associated with a significant impact on the caregiver burden, and we found also that a poor nutritional status of the older outpatient is independently more associated with the caregiver burden than cognitive and physical disability. The combined evaluation of both patients and caregivers can improve the knowledge and assistance to the elderly subjects.
Claudio Tana; Fulvio Lauretani; Andrea Ticinesi; Luciano Gionti; Antonio Nouvenne; Beatrice Prati; Tiziana Meschi; Marcello Maggio. Impact of Nutritional Status on Caregiver Burden of Elderly Outpatients. A Cross-Sectional Study. Nutrients 2019, 11, 281 .
AMA StyleClaudio Tana, Fulvio Lauretani, Andrea Ticinesi, Luciano Gionti, Antonio Nouvenne, Beatrice Prati, Tiziana Meschi, Marcello Maggio. Impact of Nutritional Status on Caregiver Burden of Elderly Outpatients. A Cross-Sectional Study. Nutrients. 2019; 11 (2):281.
Chicago/Turabian StyleClaudio Tana; Fulvio Lauretani; Andrea Ticinesi; Luciano Gionti; Antonio Nouvenne; Beatrice Prati; Tiziana Meschi; Marcello Maggio. 2019. "Impact of Nutritional Status on Caregiver Burden of Elderly Outpatients. A Cross-Sectional Study." Nutrients 11, no. 2: 281.
The capacity of Short-Physical Performance Battery (SPPB) test to discriminate between fallers and non-fallers is controversial, and has never been compared with fall risk assessment-specific tools, such as Performance-Oriented Mobility Assessment (POMA). To verify the association of SPPB and POMA scores with falls in older outpatients. 451 older subjects (150 males, mean age 82.1 ± 6.8) evaluated in a geriatric outpatient clinic for suspected frailty were enrolled in this cross-sectional study. Self-reported history of falls and medication history were carefully assessed. Each participant underwent comprehensive geriatric assessment, including SPPB, POMA, Geriatric Depression Scale (GDS), mini-mental state examination (MMSE) and mini-nutritional assessment-short form (MNA-SF). Multivariate logistic regression and receiver-operating characteristic (ROC) analyses were performed to determine the factors associated with the status of faller. 245 (54.3%) subjects were identified as fallers. They were older and had lower SPPB and POMA test scores than non-fallers. At ROC analysis, SPPB (AUC 0.676, 95% CI 0.627–0.728, p < 0.001) and POMA (AUC 0.677, 95% CI 0.627–0.726, p < 0.001) scores were both associated with falls. At multivariate logistic regression models, SPPB total score (OR 0.83, 95% CI 0.76–0.92, p < 0.001), POMA total score (OR 0.94, 95% CI 0.91–0.98, p = 0.002) and SPPB balance score alteration (OR 2.88, 95% CI 1.42–5.85, p = 0.004), but not POMA balance subscale score alteration, were independently associated with recorded falls, as also GDS, MMSE and MNA-SF scores. SPPB total score was independently associated with reported falls in older outpatients, resulting non-inferior to POMA scale. The use of SPPB for fall risk assessment should be implemented.
Fulvio Lauretani; Andrea Ticinesi; Luciano Gionti; Beatrice Prati; Antonio Nouvenne; Claudio Tana; Tiziana Meschi; Marcello Maggio. Short-Physical Performance Battery (SPPB) score is associated with falls in older outpatients. Aging Clinical and Experimental Research 2018, 31, 1435 -1442.
AMA StyleFulvio Lauretani, Andrea Ticinesi, Luciano Gionti, Beatrice Prati, Antonio Nouvenne, Claudio Tana, Tiziana Meschi, Marcello Maggio. Short-Physical Performance Battery (SPPB) score is associated with falls in older outpatients. Aging Clinical and Experimental Research. 2018; 31 (10):1435-1442.
Chicago/Turabian StyleFulvio Lauretani; Andrea Ticinesi; Luciano Gionti; Beatrice Prati; Antonio Nouvenne; Claudio Tana; Tiziana Meschi; Marcello Maggio. 2018. "Short-Physical Performance Battery (SPPB) score is associated with falls in older outpatients." Aging Clinical and Experimental Research 31, no. 10: 1435-1442.
Background: Hyperuricemia and gout represent important issues in the obese patients. Considering the epidemic trend of overweight and obesity in developed countries, the impact of these conditions is likely to increase. At present, bariatric surgery represents the most effective treatment for the management of severe obesity for reducing weight and the impact of associated comorbidities, but its effects on hyperuricemia and gout have not been fully elucidated. Methods: In this narrative review, we discuss the current knowledge about hyperuricemia and gout in obese patients undergoing bariatric surgery. We also suggest a useful approach to prevent gouty attacks in the perioperative period. Results: Weight loss seems to reduce hyperuricemia in the long-term follow-up, but there is evidence also of a high frequency of acute attacks early after surgery in patients with a diagnosis of gout. Conclusion: Bariatric surgery has a high impact on hyperuricemia and gout. A perioperative approach is suggested, based on appropriate hydration, early physical resumption, urate lowering drugs and nonsteroidal anti-inflammatory drugs (NSAIDs), or colchicine and corticosteroids if NSAIDs are ineffective or not tolerated.
Claudio Tana; Luca Busetto; Angelo Di Vincenzo; Fabrizio Ricci; Andrea Ticinesi; Fulvio Lauretani; Antonio Nouvenne; Maria Adele Giamberardino; Francesco Cipollone; Roberto Vettor; Tiziana Meschi. Management of hyperuricemia and gout in obese patients undergoing bariatric surgery. Postgraduate Medicine 2018, 130, 523 -535.
AMA StyleClaudio Tana, Luca Busetto, Angelo Di Vincenzo, Fabrizio Ricci, Andrea Ticinesi, Fulvio Lauretani, Antonio Nouvenne, Maria Adele Giamberardino, Francesco Cipollone, Roberto Vettor, Tiziana Meschi. Management of hyperuricemia and gout in obese patients undergoing bariatric surgery. Postgraduate Medicine. 2018; 130 (6):523-535.
Chicago/Turabian StyleClaudio Tana; Luca Busetto; Angelo Di Vincenzo; Fabrizio Ricci; Andrea Ticinesi; Fulvio Lauretani; Antonio Nouvenne; Maria Adele Giamberardino; Francesco Cipollone; Roberto Vettor; Tiziana Meschi. 2018. "Management of hyperuricemia and gout in obese patients undergoing bariatric surgery." Postgraduate Medicine 130, no. 6: 523-535.
Thyroid hormone variation may be correlated with adverse health outcomes, even within the normal reference range in euthyroid individuals. To determine the association between plasma thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels and physical performance score in middle age and older adults who had levels of all three hormones in the normal range. In this community-based, cross-sectional study, euthyroid participants of the Invecchiare in Chianti study, aged 23–102 years (N = 1060), were considered. Physical performance was evaluated by the Summary Physical Performance Battery (SPPB) score. Plasma TSH, FT3, and FT4 levels were predictors, and SPPB score was the outcome. At the univariate analyses, TSH, FT4, and FT3 were not significantly associated with SPPB score in young individuals, whereas, in older participants, SBBP score was positively (P < 0.001) associated with FT3, and negatively associated with both TSH (P < 0.02) and FT4 (P < 0.001). After adjusting for multiple confounders, FT3 remained significantly associated with SPPB (beta ± SE, 0.35 ± 0.17, P = 0.04), but FT4 and TSH were not. Results did not change when all the three hormones FT3, FT4, and TSH were simultaneously considered in the fully adjusted model (beta ± SE for FT3, 0.37 ± 0.18, P = 0.04). The results of this study demonstrate that SPPB score is positively associated with circulating FT3 but not with FT4 or with TSH, in older euthyroid individuals. In euthyroid older adults, circulating FT3 may play an important role in the thyroid effects on physical function.
Graziano Ceresini; Michela Marina; Fulvio Lauretani; Marcello Maggio; Maria Francesca Serra; Tiziana Meschi; Stefania Bandinelli; Gian Paolo Ceda; Luigi Ferrucci. Physical performance across the thyroid function values within the normal range in adult and older persons. Aging Clinical and Experimental Research 2018, 31, 385 -391.
AMA StyleGraziano Ceresini, Michela Marina, Fulvio Lauretani, Marcello Maggio, Maria Francesca Serra, Tiziana Meschi, Stefania Bandinelli, Gian Paolo Ceda, Luigi Ferrucci. Physical performance across the thyroid function values within the normal range in adult and older persons. Aging Clinical and Experimental Research. 2018; 31 (3):385-391.
Chicago/Turabian StyleGraziano Ceresini; Michela Marina; Fulvio Lauretani; Marcello Maggio; Maria Francesca Serra; Tiziana Meschi; Stefania Bandinelli; Gian Paolo Ceda; Luigi Ferrucci. 2018. "Physical performance across the thyroid function values within the normal range in adult and older persons." Aging Clinical and Experimental Research 31, no. 3: 385-391.
Based on meta-analyses results, it is currently acknowledged that there is an increased risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD) undergoing inhaled corticosteroids (ICS) treatment. However, this is not found to be true in those with asthma. No data on this risk are available for COPD patients involved in pulmonary rehabilitation program (PR). For 1 year, we prospectively studied 2 cohorts of COPD patients—undergoing PR and not undergoing PR. The first group included 438 patients undergoing PR of which 353 were treated with ICS, and 85 were treated with bronchodilators only. The second group was comprised of 76 COPD patients who were treated with ICS, but not PR. The control group consisted of 49 ICS-treated patients with asthma. The diagnosis of pneumonia, when suspected, had to be confirmed with a chest x-ray. Overall, 6 cases of pneumonia were diagnosed in the first study group: 5 ICS-treated patients and 1 patient treated only with bronchodilators. This corresponded to a rate of 1.41 and 1.17%, respectively, compared to a rate of 6.6% in COPD patients not treated with PR, which was significantly higher (p = 0.029) than that in the first study group. No case of pneumonia was registered among patients with asthma. These findings suggest that a significantly lower incidence of pneumonia is found in COPD patients treated with ICS and PR than in patients treated with ICS but not with PR. This observation deserves to be investigated in large populations of PR-treated COPD patients, possibly in multi-centric cohort studies.
Erminia Ridolo; Cristoforo Incorvaia; Irene Martignago; Laura Pessina; Fulvio Lauretani; Luciano Loperfido; Gian Galeazzo Riario-Sforza; Annalisa Broglia; Bruna L. Gritti; Lorenzo Panella. Low incidence of pneumonia in COPD patients treated with inhaled corticosteroids undergoing pulmonary rehabilitation. Clinical and Molecular Allergy 2018, 16, 12 .
AMA StyleErminia Ridolo, Cristoforo Incorvaia, Irene Martignago, Laura Pessina, Fulvio Lauretani, Luciano Loperfido, Gian Galeazzo Riario-Sforza, Annalisa Broglia, Bruna L. Gritti, Lorenzo Panella. Low incidence of pneumonia in COPD patients treated with inhaled corticosteroids undergoing pulmonary rehabilitation. Clinical and Molecular Allergy. 2018; 16 (1):12.
Chicago/Turabian StyleErminia Ridolo; Cristoforo Incorvaia; Irene Martignago; Laura Pessina; Fulvio Lauretani; Luciano Loperfido; Gian Galeazzo Riario-Sforza; Annalisa Broglia; Bruna L. Gritti; Lorenzo Panella. 2018. "Low incidence of pneumonia in COPD patients treated with inhaled corticosteroids undergoing pulmonary rehabilitation." Clinical and Molecular Allergy 16, no. 1: 12.
Previous observational studies using old qualitative methods have not clarified the role of amyloid positron emission tomography (PET) in the assessment of dementia. Given the moderately positive predictive value, the presence of amyloid deposition does not necessarily imply the diagnosis of dementia. Conversely, the absence of amyloid PET deposition has been shown to be useful in excluding the neurodegenerative pathology, irrespective of the aging process. We describe the clinical application of new innovative software recently developed to increase the sensitivity of this technique and to discriminate pathological deposition of cerebral amyloid from the age-related changes, reporting preliminary findings from a case-series study. In three different clinical profiles, we underline the need of integrating neuropsychological assessment and findings with this new PET scan and software that provide quantitative information of the cerebral amyloid and may increase the probability of rapid and accurate assessment of Alzheimer's disease. Although this amyloid quantification is promising, these preliminary results should be confirmed in future prospective studies with adequate sample size.
Fulvio Lauretani; Livia Ruffini; Andrea Ticinesi; Antonio Nouvenne; Marcello Maggio; Tiziana Meschi. Accuracy of Quantitative Positron Emission Tomography Assessment for Differentiating Cerebral Age-related from Pathological Amyloid Deposition: A Preliminary Report from a Case-series Study. World Journal of Nuclear Medicine 2018, 17, 106 -111.
AMA StyleFulvio Lauretani, Livia Ruffini, Andrea Ticinesi, Antonio Nouvenne, Marcello Maggio, Tiziana Meschi. Accuracy of Quantitative Positron Emission Tomography Assessment for Differentiating Cerebral Age-related from Pathological Amyloid Deposition: A Preliminary Report from a Case-series Study. World Journal of Nuclear Medicine. 2018; 17 (2):106-111.
Chicago/Turabian StyleFulvio Lauretani; Livia Ruffini; Andrea Ticinesi; Antonio Nouvenne; Marcello Maggio; Tiziana Meschi. 2018. "Accuracy of Quantitative Positron Emission Tomography Assessment for Differentiating Cerebral Age-related from Pathological Amyloid Deposition: A Preliminary Report from a Case-series Study." World Journal of Nuclear Medicine 17, no. 2: 106-111.
ObjectivesThe involvement of the gut microbiota in the pathogenesis of calcium nephrolithiasis has been hypothesised since the discovery of the oxalate-degrading activity of Oxalobacter formigenes, but never comprehensively studied with metagenomics. The aim of this case–control study was to compare the faecal microbiota composition and functionality between recurrent idiopathic calcium stone formers (SFs) and controls.DesignFaecal samples were collected from 52 SFs and 48 controls (mean age 48±11). The microbiota composition was analysed through 16S rRNA microbial profiling approach. Ten samples (five SFs, five controls) were also analysed with deep shotgun metagenomics sequencing, with focus on oxalate-degrading microbial metabolic pathways. Dietary habits, assessed through a food-frequency questionnaire, and 24-hour urinary excretion of prolithogenic and antilithogenic factors, including calcium and oxalate, were compared between SFs and controls, and considered as covariates in the comparison of microbiota profiles.ResultsSFs exhibited lower faecal microbial diversity than controls (Chao1 index 1460±363vs 1658±297, fully adjusted p=0.02 with stepwise backward regression analysis). At multivariate analyses, three taxa (Faecalibacterium, Enterobacter, Dorea) were significantly less represented in faecal samples of SFs. The Oxalobacter abundance was not different between groups. Faecal samples from SFs exhibited a significantly lower bacterial representation of genes involved in oxalate degradation, with inverse correlation with 24-hour oxalate excretion (r=−0.87, p=0.002). The oxalate-degrading genes were represented in several bacterial species, whose cumulative abundance was inversely correlated with oxaluria (r=−0.85, p=0.02).ConclusionsIdiopathic calcium SFs exhibited altered gut microbiota composition and functionality that could contribute to nephrolithiasis physiopathology.
Andrea Ticinesi; Christian Milani; Angela Guerra; Franca Allegri; Fulvio Lauretani; Antonio Nouvenne; Leonardo Mancabelli; Gabriele Andrea Lugli; Francesca Turroni; Sabrina Duranti; Marta Mangifesta; Alice Viappiani; Chiara Ferrario; Rossella Dodi; Margherita Dall’Asta; Daniele Del Rio; Marco Ventura; Tiziana Meschi. Understanding the gut–kidney axis in nephrolithiasis: an analysis of the gut microbiota composition and functionality of stone formers. Gut 2018, 67, 2097 -2106.
AMA StyleAndrea Ticinesi, Christian Milani, Angela Guerra, Franca Allegri, Fulvio Lauretani, Antonio Nouvenne, Leonardo Mancabelli, Gabriele Andrea Lugli, Francesca Turroni, Sabrina Duranti, Marta Mangifesta, Alice Viappiani, Chiara Ferrario, Rossella Dodi, Margherita Dall’Asta, Daniele Del Rio, Marco Ventura, Tiziana Meschi. Understanding the gut–kidney axis in nephrolithiasis: an analysis of the gut microbiota composition and functionality of stone formers. Gut. 2018; 67 (12):2097-2106.
Chicago/Turabian StyleAndrea Ticinesi; Christian Milani; Angela Guerra; Franca Allegri; Fulvio Lauretani; Antonio Nouvenne; Leonardo Mancabelli; Gabriele Andrea Lugli; Francesca Turroni; Sabrina Duranti; Marta Mangifesta; Alice Viappiani; Chiara Ferrario; Rossella Dodi; Margherita Dall’Asta; Daniele Del Rio; Marco Ventura; Tiziana Meschi. 2018. "Understanding the gut–kidney axis in nephrolithiasis: an analysis of the gut microbiota composition and functionality of stone formers." Gut 67, no. 12: 2097-2106.
Venous thromboembolism (VTE) is a common and potentially life-threatening condition which includes both deep-vein thrombosis (DVT) and pulmonary embolism (PE). VTE has a significant clinical and epidemiological impact in the elderly, and its incidence increases to more than 1% per year in older patients, suggesting the presence of specific age-related risk factors in this population. Immobilization seems to predominate as the main cause in patients admitted for medical acute illness in medicine wards, and there is evidence of a high risk in older patients with immobilization resulting from advanced forms of Parkinson’s disease (PD), regardless of the presence of an acute medical condition. In this review, we would to discuss the recent evidence on clinical, molecular and epidemiological features of VTE in older frail subjects focusing on patients with PD and parkinsonism. We also discuss some therapeutic issues about the risk prevention and we suggest a thorough comprehensive geriatric assessment that can represent an optimal strategy to identify and prevent the VTE risk in these patients.
Claudio Tana; Fulvio Lauretani; Andrea Ticinesi; Beatrice Prati; Antonio Nouvenne; Tiziana Meschi. Molecular and Clinical Issues about the Risk of Venous Thromboembolism in Older Patients: A Focus on Parkinson’s Disease and Parkinsonism. International Journal of Molecular Sciences 2018, 19, 1299 .
AMA StyleClaudio Tana, Fulvio Lauretani, Andrea Ticinesi, Beatrice Prati, Antonio Nouvenne, Tiziana Meschi. Molecular and Clinical Issues about the Risk of Venous Thromboembolism in Older Patients: A Focus on Parkinson’s Disease and Parkinsonism. International Journal of Molecular Sciences. 2018; 19 (5):1299.
Chicago/Turabian StyleClaudio Tana; Fulvio Lauretani; Andrea Ticinesi; Beatrice Prati; Antonio Nouvenne; Tiziana Meschi. 2018. "Molecular and Clinical Issues about the Risk of Venous Thromboembolism in Older Patients: A Focus on Parkinson’s Disease and Parkinsonism." International Journal of Molecular Sciences 19, no. 5: 1299.
Muscle ultrasound (MUS) has so far not been implemented for sarcopenia assessment in clinical geriatric practice due to allegedly low reproducibility of results in the absence of standardization of procedures. However, rigorous and standardized application of this technique yields highly reproducible results. Its application, especially if integrated with clinical evaluation and comprehensive geriatric assessment, proofs very useful for rapidly obtaining information on muscle mass and architecture. Here, we present a standardized protocol for performing right vastus lateralis (RVL) MUS and measuring parameters of muscle size and architecture. RVL muscle thickness (MT), fascicle length (FL), pennation angle (PA), echo-intensity (EI) and cross-sectional area (CSA) can be assessed with this protocol. A portable instrument equipped with a 5-cm long 3–11 mHz linear probe should be used with both B-mode real-time and extended-field-of-view (EFOV) techniques. Longitudinal B-mode and transverse EFOV images should be acquired during each exam, and analyzed with NIH-ImageJ software. This operative protocol represents a good compromise between the feasibility of MUS in clinical settings and the need of obtaining precise measurements of muscle parameters. Future studies should verify the reproducibility of the proposed technique, and its correlation with appendicular lean mass and parameters of muscle function.
Andrea Ticinesi; Marco V. Narici; Fulvio Lauretani; Antonio Nouvenne; Elena Colizzi; Marco Mantovani; Andrea Corsonello; Francesco Landi; Tiziana Meschi; Marcello Maggio. Assessing sarcopenia with vastus lateralis muscle ultrasound: an operative protocol. Aging Clinical and Experimental Research 2018, 30, 1437 -1443.
AMA StyleAndrea Ticinesi, Marco V. Narici, Fulvio Lauretani, Antonio Nouvenne, Elena Colizzi, Marco Mantovani, Andrea Corsonello, Francesco Landi, Tiziana Meschi, Marcello Maggio. Assessing sarcopenia with vastus lateralis muscle ultrasound: an operative protocol. Aging Clinical and Experimental Research. 2018; 30 (12):1437-1443.
Chicago/Turabian StyleAndrea Ticinesi; Marco V. Narici; Fulvio Lauretani; Antonio Nouvenne; Elena Colizzi; Marco Mantovani; Andrea Corsonello; Francesco Landi; Tiziana Meschi; Marcello Maggio. 2018. "Assessing sarcopenia with vastus lateralis muscle ultrasound: an operative protocol." Aging Clinical and Experimental Research 30, no. 12: 1437-1443.
Sexuality is defined as the dynamic outcome of physical capacity, motivation, attitudes, opportunity for partnership, and sexual conduct. Sexual health in older persons is a topic deserving increasing interest and attention for both a public audience and physicians. Over half of people over 65 years of age, report sexual dysfunction, women more so than men. Since sexual health is dependent on general health and can be considered a mirror of general health, its assessment should be part of the routine clinical assessment, even in older subjects. However, asking about sexual health especially in older persons is often a difficult or embarrassing task for many primary care physicians. In addition, many patients find difficult to raise sexual issues with their doctor. Early recognition of sexual symptoms is the first step to starting multimodal treatments aimed at improving sexual health and related quality of life in older persons.
Marcello Maggio; Fulvio Lauretani; Gian Paolo Ceda. Sexuality in older persons. Oxford Textbook of Geriatric Medicine 2017, 1149 -1156.
AMA StyleMarcello Maggio, Fulvio Lauretani, Gian Paolo Ceda. Sexuality in older persons. Oxford Textbook of Geriatric Medicine. 2017; ():1149-1156.
Chicago/Turabian StyleMarcello Maggio; Fulvio Lauretani; Gian Paolo Ceda. 2017. "Sexuality in older persons." Oxford Textbook of Geriatric Medicine , no. : 1149-1156.
Inadequate nutrition and physical inactivity are the mainstays of primary sarcopenia–physiopathology in older individuals. Gut microbiota composition is strongly dependent on both of these elements, and conversely, can also influence the host physiology by modulating systemic inflammation, anabolism, insulin sensitivity, and energy production. The bacterial metabolism of nutrients theoretically influences skeletal muscle cell functionality through producing mediators that drive all of these systemic effects. In this study, we review the scientific literature supporting the concept of the involvement of gut microbiota in primary sarcopenia physiopathology. First, we examine studies associating fecal microbiota alterations with physical frailty, i.e., the loss of muscle performance and normal muscle mass. Then, we consider studies exploring the effects of exercise on gut microbiota composition. Finally, we examine studies demonstrating the possible effects of mediators produced by gut microbiota on skeletal muscle, and intervention studies considering the effects of prebiotic or probiotic administration on muscle function. Even if there is no evidence of a distinct gut microbiota composition in older sarcopenic patients, we conclude that the literature supports the possible presence of a “gut–muscle axis”, whereby gut microbiota may act as the mediator of the effects of nutrition on muscle cells.
Andrea Ticinesi; Fulvio Lauretani; Christian Milani; Antonio Nouvenne; Claudio Tana; Daniele Del Rio; Marcello Maggio; Marco Ventura; Tiziana Meschi. Aging Gut Microbiota at the Cross-Road between Nutrition, Physical Frailty, and Sarcopenia: Is There a Gut–Muscle Axis? Nutrients 2017, 9, 1303 .
AMA StyleAndrea Ticinesi, Fulvio Lauretani, Christian Milani, Antonio Nouvenne, Claudio Tana, Daniele Del Rio, Marcello Maggio, Marco Ventura, Tiziana Meschi. Aging Gut Microbiota at the Cross-Road between Nutrition, Physical Frailty, and Sarcopenia: Is There a Gut–Muscle Axis? Nutrients. 2017; 9 (12):1303.
Chicago/Turabian StyleAndrea Ticinesi; Fulvio Lauretani; Christian Milani; Antonio Nouvenne; Claudio Tana; Daniele Del Rio; Marcello Maggio; Marco Ventura; Tiziana Meschi. 2017. "Aging Gut Microbiota at the Cross-Road between Nutrition, Physical Frailty, and Sarcopenia: Is There a Gut–Muscle Axis?" Nutrients 9, no. 12: 1303.
The association of metabolic syndrome (MetS) traits with urinary calcium (UCE) or oxalate excretion (UOE) is uncertain in calcium stone formers (CSFs). Our aim was to investigate this association in a large group of Caucasian CSFs. We retrospectively reviewed data of CSFs evaluated at our Kidney Stone Clinic from 1984 to 2015. Data on body mass index (BMI), MetS traits defined according to international consensus, family history of urolithiasis, anti-hypertensive treatments, calcemia, renal function, and 24-h urinary profile of lithogenic risk were collected. The association between MetS traits and UCE or UOE was tested with multivariate linear regression models accounting for a long list of potential confounders. We included 3003 CSFs, aged 44 ± 14 years. The prevalence of hypertension, diabetes, overweight (BMI ≥ 25 kg/m2) and dyslipidemia was 17, 2, 42 and 38%, respectively. Median values of UCE and UOE were 211 mg/24 h (IQR 143–296) and 28 mg/24 h (IQR 22–34), respectively. At a multivariate model, including age, sex, date of examination, drug treatments, family history, renal function, blood calcium and urinary factors as covariates, hypertension was a significant positive determinant of UCE (β ± SE 0.23 ± 0.07, p = 0.003), but overweight, dyslipidemia and diabetes were not. No MetS trait was significantly associated with UOE in multivariate models. In a large group of Caucasian CSFs, hypertension was the only MetS trait significantly associated with UCE, while no MetS trait was associated with oxalate excretion.
Andrea Ticinesi; Angela Guerra; Franca Allegri; Antonio Nouvenne; Gianfranco Cervellin; Marcello Maggio; Fulvio Lauretani; Loris Borghi; Tiziana Meschi. Determinants of calcium and oxalate excretion in subjects with calcium nephrolithiasis: the role of metabolic syndrome traits. Journal of Nephrology 2017, 31, 395 -403.
AMA StyleAndrea Ticinesi, Angela Guerra, Franca Allegri, Antonio Nouvenne, Gianfranco Cervellin, Marcello Maggio, Fulvio Lauretani, Loris Borghi, Tiziana Meschi. Determinants of calcium and oxalate excretion in subjects with calcium nephrolithiasis: the role of metabolic syndrome traits. Journal of Nephrology. 2017; 31 (3):395-403.
Chicago/Turabian StyleAndrea Ticinesi; Angela Guerra; Franca Allegri; Antonio Nouvenne; Gianfranco Cervellin; Marcello Maggio; Fulvio Lauretani; Loris Borghi; Tiziana Meschi. 2017. "Determinants of calcium and oxalate excretion in subjects with calcium nephrolithiasis: the role of metabolic syndrome traits." Journal of Nephrology 31, no. 3: 395-403.