Vitamins are essential for a healthy life. Compared to other nutrients, the body needs them in very small amounts. B vitamins, often known as the vitamin B complex, are a class of water-soluble vitamins with key functions in cellular metabolism. Thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), biotin (vitamin B7), folate (vitamin B9), often known as folic acid, and cobalamin (vitamin B12) are the eight distinct vitamins that collectively constitute the vitamin B complex. The body's energy levels, cognitive activity, and cell metabolism are all directly impacted by B vitamins. Four main factors contribute to vitamin B deficiency: an unbalanced diet, excessive alcohol intake, different drugs, and disorders that induce gut malabsorption. If these B vitamin deficiencies are left untreated, they can eventually cause symptoms such as peripheral neuropathy, heart attacks, strokes etc. B vitamins are present in natural, whole foods. Compared to their unprocessed counterparts, white flour and other processed carbohydrates like sugar often contain fewer B vitamins. Excellent sources of vitamins Bs comprise legumes (beans or pulses), potatoes, bananas, whole grains, tempeh, chilli peppers, brewer's yeast, nutritional yeast, and molasses. This paper provides an in-depth summary of the most popular types of vitamin B, emphasizing why the body needs them, the symptoms of a deficiency, and what diet or foods are rich in them.

The hepatoprotective potential of grape and polyphenols has been scientifically well demonstrated in several experimental studies. However, there is no systematic review performed on their hepatoprotective activity. Based on scientific evidence, the goal of this systematic review was to describe and make inferences on the therapeutic advantages of grape and polyphenols against various chemical hepatotoxicities. Grape and polyphenols from preclinical and clinical studies were included for the online search utilising electronic databases such as PubMed, Web of Science, Scopus, Springer Nature, and Google Scholar. The searched words and terms were: “Hepatotoxicity” OR “Hepatoprotective” OR “Liver injury” AND “Hepatotoxic drug” AND “Grape” OR “Grapefruit” OR “Grape seed” OR “Grape peels” OR “Bioactive compounds” OR “Polyphenols” AND “Preclinical studies” OR “Clinical studies”. A total of sixty-five studies were included based on the rigorous inclusion and exclusion criteria. The systematic review revealed that grape and polyphenolic compounds could significantly alleviate hepatic markers (ALP, ALT and AST), antioxidant status (CAT, GPx, GSH and SOD), hepatic anti-inflammatory status (TNF-α, IL-1, IL-6, COX-2, and NF-κB pathways) and apoptosis markers [caspase-3 (CASP) and caspase-9] in chemical induced-hepatotoxicity. Furthermore, improvements in the structural, functional, and physiological characteristics of the liver were observed after treatment with grape and polyphenols, reflecting modulation in the cellular and molecular alterations. Conclusively, this study supports the therapeutic potential of grape and polyphenols for the management of hepatotoxicity in various conditions based on available scientific evidence.

Ashwagandha ( Withania somnifera ), which is widely used in Ayurveda and other system of medicine, is best known for its ability to reduce depression and associated problems. Notably, important constituents of the body such as enzymes are intimately associated with the chemicals present in...