A brain tumor is an abnormal growth of brain cells inside the head, which reduces the patient's survival chance if it is not diagnosed at an earlier stage. Brain tumors vary in size, different in type, irregular in shapes and require distinct therapies for different patients. Manual diagnosis of brain tumors is less efficient, prone to error and time-consuming. Besides, it is a strenuous task, which counts on radiologist experience and proficiency. Therefore, a modern and efficient automated computer-assisted diagnosis (CAD) system is required which may appropriately address the aforementioned problems at high accuracy is presently in need. Aiming to enhance performance and minimise human efforts, in this manuscript, the first brain MRI image is pre-processed to improve its visual quality and increase sample images to avoid over-fitting in the network. Second, the tumor proposals or locations are obtained based on the agglomerative clustering-based method. Third, image proposals and enhanced input image are transferred to backbone architecture for features extraction. Fourth, high-quality image proposals or locations are obtained based on a refinement network, and others are discarded. Next, these refined proposals are aligned to the same size, and finally, transferred to the head network to achieve the desired classification task. The proposed method is a potent tumor grading tool assessed on a publicly available brain tumor dataset. Extensive experiment results show that the proposed method outperformed the existing approaches evaluated on the same dataset and achieved an optimal performance with an overall classification accuracy of 98.04%. Besides, the model yielded the accuracy of 98.17, 98.66, 99.24%, sensitivity (recall) of 96.89, 97.82, 99.24%, and specificity of 98.55, 99.38, 99.25% for Meningioma, Glioma, and Pituitary classes, respectively.

The precise and timely diagnosis of brain tumors is essential for accelerating patient recovery and preserving lives. Brain tumors exhibit a variety of sizes, shapes, and visual characteristics, requiring individualized treatment strategies for each patient. Radiologists require considerable proficiency to manually detect brain malignancies. However, tumor recognition remains inefficient, imprecise, and labor-intensive in manual procedures, underscoring the need for automated methods. This study introduces an effective approach for identifying brain lesions in magnetic resonance imaging (MRI) images, minimizing dependence on manual intervention. The proposed method improves image clarity by combining guided filtering techniques with anisotropic Gaussian side windows (AGSW). A morphological analysis is conducted prior to segmentation to exclude non-tumor regions from the enhanced MRI images. Deep neural networks segment the images, extracting high-quality regions of interest (ROIs) and multiscale features. Identifying salient elements is essential and is accomplished through an attention module that isolates distinctive features while eliminating irrelevant information. An ensemble model is employed to classify brain tumors into different categories. The proposed technique achieves an overall accuracy of 99.94% and 99.67% on the publicly available brain tumor datasets BraTS2020 and Figshare, respectively. Furthermore, it surpasses existing technologies in terms of automation and robustness, thereby enhancing the entire diagnostic process.

In this paper, a novel fractional-order fusion model (FFM) is presented for low-light image enhancement. Existing image enhancement methods don’t adequately extract contents from low-light areas, suppress noise, and preserve naturalness. To solve these problems, the main contributions of this paper are using fractional-order mask and the fusion framework to enhance the low-light image. Firstly, the fractional mask is utilized to extract illumination from the input image. Secondly, image exposure adjusts to visible the dark regions. Finally, the fusion approach adopts the extracting of more hidden contents from dim areas. Depending on the experimental results, the fractional-order differential is much better for preserving the visual appearance as compared to traditional integer-order methods. The FFM works well for images having complex or normal low-light conditions. It also shows a trade-off among contrast improvement, detail enhancement, and preservation of the natural feel of the image. Experimental results reveal that the proposed model achieves promising results, and extracts more invisible contents in dark areas. The qualitative and quantitative comparison of several recent and advance state-of-the-art algorithms shows that the proposed model is robust and efficient.

Designing molecules for drugs has been a hot topic for many decades. However, it is hard and expensive to find a new molecule. Thus, the cost of the final drug is also increased. Machine learning can provide the fastest way to predict the biological activity of druglike molecules. In the present work, machine learning models are trained for the prediction of the biological activity of aromatase inhibitors. Data was collected from the literature. Molecular descriptors are calculated to be used as independent features for model training. The results showed that the R ² values for linear regression, random forest regression, gradient boosting regression, and bagging regression are 0.58, 0.84, 0.77, and 0.80, respectively. Using these models, it is possible to predict the activity of new molecules in a short period of time and at a reasonable cost. Furthermore, Tanimoto similarity is used for similarity analysis, as well as a chemical database is mined to search for similar molecules. Nonetheless, this study provides a framework for repurposing other effective drug molecules to prevent cancer.