Colorectal cancer (CRC) is the third most common cancer diagnosed in the United States, excluding nonmelanoma skin cancers.¹ The median age of CRC diagnosis is 69 years in males and 73 years in females; 10% of patients with CRC are diagnosed when they are younger than 50 years.¹ Early-onset cancer is a hallmark of inherited cancer predisposition. Identification of hereditary cancer syndromes has significant implications for patients and families, as it facilitates risk assessment, directs clinical management, and can guide treatment options.

The American Journal of Gastroenterology is published by Nature Publishing Group (NPG) on behalf of the American College of Gastroenterology (ACG). Ranked the #1 clinical journal covering gastroenterology and hepatology*, The American Journal of Gastroenterology (AJG) provides practical and professional support for clinicians dealing with the gastroenterological disorders seen most often in patients. Published with practicing clinicians in mind, the journal aims to be easily accessible, organizing its content by topic, both online and in print. www.amjgastro.com, *2007 Journal Citation Report (Thomson Reuters, 2008)