The harm of air pollution to public health has become a research hotspot, especially atmospheric fine-particulate matter (PM_2.5). In recent years, epidemiological investigations have confirmed that PM_2.5 is closely related to chronic kidney disease and membranous nephropathy Basic research has demonstrated that PM_2.5 has an impact on the normal function of the kidneys through accumulation in the kidney, endothelial dysfunction, abnormal renin-angiotensin system, and immune complex deposition. Moreover, the mechanism of PM_2.5 damage to the kidney involves inflammation, oxidative stress, apoptosis, DNA damage, and autophagy. In this review, we summarized the latest developments in the effects of PM_2.5 on kidney disease in human and animal studies, so as to provide new ideas for the prevention and treatment of kidney disease.