An iterative learning fault-tolerant control method is designed for an actuator fault intermittent process with simultaneous uncertainties for the system parameters. First, an intermittent fault tolerance controller is designed using 2D system theory, and the iterative learning control (ILC) intermittent process is transformed into a 2D Roesser model. Secondly, sufficient conditions for the controller’s existence are analyzed using the linear matrix inequality (LMI) technique, and the control gain matrices are obtained by convex optimization with LMI constraints. Under these conditions for all additive uncertainties for the system parameters and admissible failures, the controller can ensure closed-loop fault-tolerant performance in both the time and batch directions, and it can also meet the H∞ robust performance level against outside disturbances. Eventually, the algorithm’s computational complexity is analyzed, and the effectiveness of the algorithm is verified by simulation with respect to an injection molding machine model. Compared with traditional ILC laws, which do not consider actuator faults, the proposed algorithm has a better convergence speed and stability when the time-invariant and time-variant actuator faults occur during implementation.