Shengrong Guo

Dr. Shengrong Guo


Research Focus & Metrics

Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2014 in Journal of Controlled Release
Verified
Journal Article
Closed access
FWFeihu Wang
Feihu Wang
YWYun Wang
Yun Wang
XZXiao Zhang
Xiao Zhang
WZWenjun Zhang
Wenjun Zhang
SGShengrong Guo
Shengrong Guo
FJFang Jin
Fang Jin

21 September 2016 in Advanced Synthesis & Catalysis
Verified
Journal Article
Closed access
PDF file
SGShengrong Guo
Shengrong Guo
PKPailla Santhosh Kumar
Pailla Santhosh Kumar
MYMinghua Yang
Minghua Yang

1 June 2016 in Journal of Controlled Release
Verified
Journal Article
Open access
WZWenjun Zhang
Wenjun Zhang
FWFeihu Wang
Feihu Wang
YWYun Wang
Yun Wang
JWJining Wang
Jining Wang
YYYanna Yu
Yanna Yu
DZDejian Zhou
Dejian Zhou
A thiolated pH-responsive DNA conjugated gold nanorod (GNR) was developed as a multifunctional nanocarrier for targeted, pH-and near infrared (NIR) radiation dual-stimuli triggered drug delivery. It was further passivated by a thiolated poly(ethylene glycol)-biotin to improve its cancer targeting ability by specific binding to cancer cell over-expressed biotin receptors. Doxorubicin (DOX), a widely used clinical anticancer drug, was conveniently loaded into nanocarrier by intercalating inside the double-stranded pH-responsive DNAs on the GNR surface to complete the construction of the multifunctional nanomedicine. The nanomedicine can rapidly and effectively release its DOX payload triggered by an acidic pH environment (pH~5) and/or applying an 808nm NIR laser radiation. Compared to free DOX, the biotin-modified nanomedicine displayed greatly increased cell uptake and significantly reduced drug efflux by model multidrug resistant (MDR) breast cancer cell lines (MCF-7/ADR). The application of NIR radiation further increased the DOX release and facilitated its nuclear accumulation. As a result, this new DNA-GNR based multifunctional nanomedicine exerted greatly increased potency (~67 fold) against the MDR cancer cells over free DOX.

1 October 2024 in Progress in Materials Science
Verified
Journal Article
Closed access
JZJunrui Zhang
Junrui Zhang
MLMili Liu
Mili Liu
JQJiacheng Qi
Jiacheng Qi
NLNuo Lei
Nuo Lei
SGShengrong Guo
Shengrong Guo
Liuzhang OuyangLiuzhang Ouyang
Liuzhang Ouyang

12 June 2014 in Chemical Communications
Verified
Journal Article
Closed access
PDF file
SGShengrong Guo
Shengrong Guo
WHWei-Ming He
Wei-Ming He
JXJian-Nan Xiang
Jian-Nan Xiang
YYYan-Qin Yuan
Yan-Qin Yuan
A new method for the preparation of alkyl aryl sulfides through direct oxidative thiolation of alkanes or ethers with arylsulfonyl hydrazides using DTBP as an oxidant catalyzed by Pd(OAc)2 has been reported. The C–H bonds in various alkanes or ethers were successfully converted into C–S bonds with moderate to good yields.

1 September 2017 in Acta Biomaterialia
Verified
Journal Article
Closed access
YYYanna Yu
Yanna Yu
ZZZhipeng Zhang
Zhipeng Zhang
YWYun Wang
Yun Wang
HZHao Zhu
Hao Zhu
FLFangzhou Li
Fangzhou Li
SGShengrong Guo
Shengrong Guo