Of all the renewable power generation technologies, solar tower power system is expected to be the most promising technology that is capable of large-scale electricity production. However, the optimization of heliostat field layout is a complicated process, in which thousands of heliostats have to be considered for any heliostat field optimization process. Therefore, in this paper, in order to optimize the heliostat field to obtain the highest energy collected per unit cost (ECUC), a mathematical model of a heliostat field and a hybrid algorithm combining particle swarm optimization algorithm and genetic algorithm (PSO-GA) are coded in Matlab and the heliostat field in Lhasa is investigated as an example. The results show that, after optimization, the annual efficiency of the heliostat field increases by approximately six percentage points, and the ECUC increases from 12.50 MJ/USD to 12.97 MJ/USD, increased about 3.8%. Studies on the key parameters indicate that: for un-optimized filed, ECUC first peaks and then decline with the increase of the number of heliostats in the first row of the field (Nhel₁). By contrast, for optimized field, ECUC increases with Nhel₁. What is more, for both the un-optimized and optimized field, ECUC increases with tower height and decreases with the cost of heliostat mirror collector.