Maneeth Mylavarapu

Dr. Maneeth Mylavarapu

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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2 January 2024 in Cureus
Verified
Journal Article
Open access
DSDhruvikumari D Sharma
Dhruvikumari D Sharma
NCNidhi R Chandresh
Nidhi R Chandresh
AJAyesha Javed
Ayesha Javed
PGPeter Girgis
Peter Girgis
MZMadiha Zeeshan
Madiha Zeeshan
MMManeeth Mylavarapu
Maneeth Mylavarapu
Preeclampsia (PE) is a disease in pregnancy that is characterized by new-onset hypertension end-organ dysfunction, often occurring after 20 weeks of gestation. Risk factors include a prior history of PE, diabetes, kidney disease, obesity, and high maternal age at pregnancy. Current treatment and management guidelines focus on the management of high blood pressure and any potential complications. The only known curative treatment is termination of pregnancy (either induction of delivery or cesarean section). However, the current guidelines and recommendations lack adequate prediction markers and are unable to prevent maternal and fetal mortality. There also exists a need for multidisciplinary collaborative action in view of the quality of life and psycho-educational counseling.

27 June 2025 in Reviews in Cardiovascular Medicine
Verified
Journal Article
Open access
NJNihar K Jena
Nihar K Jena
PSprabhat singh
prabhat singh
DCDeepak Chandramohan
Deepak Chandramohan
HGHari Naga Garapati
Hari Naga Garapati
JGJyotsna Gummadi
Jyotsna Gummadi
PSprathap kumar Simhadri
prathap kumar Simhadri
As the use of wearable devices continues to expand, their integration into various aspects of healthcare becomes increasingly prevalent. Indeed, significant advancements have been made in the field of cardiology through the application of wearable technology to monitor heart rate, rhythm, and other biological signals. This review examines the various applications of wearable technology in cardiology, with the goal of improving patient care. We evaluate the accuracy and functionality of existing wearable electrocardiograms, defibrillators, blood pressure monitors, fitness trackers, activity trackers, and sleep trackers, including their roles in cardiac rehabilitation. Furthermore, we highlight the significant advancements in wearable electrocardiograms, demonstrating their accuracy comparable to that of traditional monitoring devices, as shown by studies such as the Apple Heart Study and the Fitbit Heart Study. Recent research suggests that wearable electrocardiograms are comparable to conventional monitoring devices in terms of performance and can help reduce healthcare costs. However, as technological improvements continue to evolve, challenges related to accessibility, patient privacy, and the need for improved accuracy are also emerging. This review highlights recent advancements that aim to address these challenges. Nonetheless, further research is crucial to critically assess and identify shortcomings, as wearable devices possess significant potential to enhance cardiovascular and overall health.

1 January 2026 in Cardiology Research and Practice
Verified
Journal Article
Open access
MMManeeth Mylavarapu
Maneeth Mylavarapu
ATANGAD TIWARI
ANGAD TIWARI
HKHarshaman Kaur
Harshaman Kaur
RVRoopeessh Vempati
Roopeessh Vempati
Harendra KumarHarendra Kumar
Harendra Kumar
VPVikramjit S. Purewal
Vikramjit S. Purewal
This review examines the bidirectional relationship between the gut microbiota and cardiovascular diseases (CVDs), aiming to understand how microbial dysbiosis contributes to CVDs, including atherosclerosis, hypertension, and heart failure. Recent research emphasizes the gut microbiota’s role in modulating immunity via SCFAs and tryptophan metabolites, maintaining intestinal barrier integrity, and producing metabolites such as SCFAs (acetate, propionate, butyrate) and pro‐atherogenic TMAO. Dietary patterns, particularly the Mediterranean versus Western diet, significantly influence gut microbiota composition and CVD risk. Polyphenols and exercise have shown positive effects on gut microbiota and cardiovascular outcomes. A significant interplay exists between gut microbiota and cardiovascular health. Dysbiosis and metabolites like TMAO and LPS are implicated in CVD, while SCFAs and a balanced microbiota offer protection. Future research should focus on precision medicine, next‐gen probiotics, optimized FMT, and multiomics approaches to identify personalized CVD therapies.

24 December 2025 in Cells
Verified
Journal Article
Open access
PDF file
MSMuhammad Sanusi
Muhammad Sanusi
RVRoopeessh Vempati
Roopeessh Vempati
DUDinakaran Umashankar
Dinakaran Umashankar
STSuha Tarannum
Suha Tarannum
YVYash Varma
Yash Varma
CGChristian C. Toquica Gahona
Christian C. Toquica Gahona
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia globally, linked to significant cardiovascular morbidity and mortality. Catheter ablation has emerged as a primary therapeutic approach, yet substantial recurrence rates limit its long-term efficacy. This review critically examines the molecular mechanisms underlying AF recurrence post-ablation, synthesizing recent findings from current literature. Key molecular pathways identified include structural remodeling mediated by fibrosis involving transforming growth factor-beta 1 (TGF-β1) and matrix metalloproteinases (MMPs), ion-channel dysregulation, inflammatory pathways, autonomic nervous system imbalance, and genetic and epigenetic alterations. Despite considerable advances, critical gaps persist due to small, heterogeneous studies and insufficient long-term follow-up. Comprehensive mechanistic research integrating genomics, proteomics, and advanced imaging is urgently needed to better characterize these pathways. Future studies must validate biomarkers such as TGF-β1, MMPs, connexins, and novel markers like GDF-15 and relaxin. Clinical translation of these molecular insights through precision diagnostics and personalized interventions holds great promise to enhance patient selection, optimize ablation strategies, reduce recurrence, and ultimately improve clinical outcomes in AF management.

4 March 2024 in Journal of Asthma
Verified
Journal Article
Closed access
TSTahoora Abdul Nasir Surve
Tahoora Abdul Nasir Surve
DSDhruviKumari D Sharma
DhruviKumari D Sharma
KKKiyan Ghani Khan
Kiyan Ghani Khan
NGNeisha Ghanie
Neisha Ghanie
RCRiley Charanrak
Riley Charanrak
MMManeeth Mylavarapu
Maneeth Mylavarapu
Objective To emphasize the necessity for increased research in this field, incorporating depression into the preventative, diagnostic, and therapeutic considerations for asthma. Additionally, we seek to highlight upcoming advancements that can be applied to simultaneously address these comorbidities, ultimately improving the overall well-being and quality of life for individuals coping with these conditions.Methods A rigorous search in PubMed using the MeSH terms "asthma" and "depression" was performed, and papers were screened by the authors in view of their eligibility to contribute to the study.Results There exists a correlation between these two conditions, with specific biological mechanisms and genetic factors playing a crucial role in their concurrent occurrence. In this review, we present preclinical and clinical research data, shed light on the possible mechanisms contributing to the co-occurrence of symptoms associated with both asthma and depression, and explore the intricate relationship between both conditions.Conclusion The evidence presented here supports the existence of a correlation between asthma and depression. By acknowledging these shared biological mechanisms, genetic factors, and epidemiological trends, we can formulate more efficacious strategies for addressing the dual impact of asthma and depression.

14 March 2024 in Infection
Verified
Journal Article
Closed access
PDF file
VSVivek Sanker
Vivek Sanker
MMManeeth Mylavarapu
Maneeth Mylavarapu
PGPrakash Gupta
Prakash Gupta
NSNaureen Syed
Naureen Syed
MSMaitri Shah
Maitri Shah
VDVenkata Vamshi Krishna Dondapati
Venkata Vamshi Krishna Dondapati