DAIANA LOPES

Dr. DAIANA LOPES


Research Focus & Metrics

Academic Career Length

19Years (2008-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 February 2013 in Parasitology
Verified
Journal Article
Closed access
PDF file
DNDébora C. O. Nunes
Débora C. O. Nunes
MFMárcia M. N. R. Figueira
Márcia M. N. R. Figueira
DLDAIANA LOPES
DAIANA LOPES
DSDayane L. Naves DE Souza
Dayane L. Naves DE Souza
LILuiz Fernando M. Izidoro
Luiz Fernando M. Izidoro
KYKelly A. G. Yoneyama
Kelly A. G. Yoneyama
SUMMARY: This paper reports the effects of BnSP-7 toxin, a catalytically inactive phospholipase A2 from Bothrops pauloensis snake venom, on Leishmania (Leishmania) amazonensis. BnSP-7 presented activity against promastigote parasite forms both in the MTT assay, with IC50 of 58·7 μg mL−1 of toxin, and a growth curve, inhibiting parasite proliferation 60–70% at concentrations of 50–200 μg mL−1 of toxin 96 h after treatment. Also, the toxin presented effects on amastigotes, reducing parasite viability by 50% at 28·1 μg mL−1 and delaying the amastigote–promastigote differentiation process. Ultrastructural studies showed that BnSP-7 caused severe morphological changes in promastigotes such as mitochondrial swelling, nuclear alteration, vacuolization, acidocalcisomes, multiflagellar aspects and a blebbing effect in the plasma membrane. Finally, BnSP-7 interfered with the infective capacity of promastigotes in murine peritoneal macrophages, causing statistically significant infectivity-index reductions (P < 0·05) of 20–35%. These data suggest that the BnSP-7 toxin is an important tool for the discovery of new parasite targets that can be exploited to develop new drugs for treating leishmaniasis.

1 January 2016 in International Journal of Biological Macromolecules
Verified
Journal Article
Closed access
Fernanda Van Petten AzevedoFernanda Van Petten Azevedo
Fernanda Van Petten Azevedo
DLDAIANA LOPES
DAIANA LOPES
SGSarah Gimenes
Sarah Gimenes
DADavid Collares Achê
David Collares Achê
LVLara Vecchi
Lara Vecchi
KYKelly Aparecida Geraldo Yoneyama
Kelly Aparecida Geraldo Yoneyama

1 June 2019 in Journal of Inorganic Biochemistry
Verified
Journal Article
Closed access
MCMônica Soares Costa
Mônica Soares Costa
YGYasmim Garcia Gonçalves
Yasmim Garcia Gonçalves
STSamuel Cota Teixeira
Samuel Cota Teixeira
DNDébora Cristina de Oliveira Nunes
Débora Cristina de Oliveira Nunes
DLDAIANA LOPES
DAIANA LOPES
KYKelly Aparecida Geraldo Yoneyama
Kelly Aparecida Geraldo Yoneyama

1 October 2018 in International Journal of Biological Macromolecules
Verified
Journal Article
Closed access
MSMakswell Almeida Silva
Makswell Almeida Silva
DLDAIANA LOPES
DAIANA LOPES
STSamuel Cota Teixeira
Samuel Cota Teixeira
SGSarah Gimenes
Sarah Gimenes
Fernanda Van Petten AzevedoFernanda Van Petten Azevedo
Fernanda Van Petten Azevedo
RRRenata Santos Rodrigues
Renata Santos Rodrigues

1 April 2017 in International Journal of Biological Macromolecules
Verified
Journal Article
Closed access
DGDenise de Oliveira Guimarães
Denise de Oliveira Guimarães
DLDAIANA LOPES
DAIANA LOPES
Fernanda Van Petten AzevedoFernanda Van Petten Azevedo
Fernanda Van Petten Azevedo
SGSarah Gimenes
Sarah Gimenes
MSMakswell Almeida Silva
Makswell Almeida Silva
VRVeridiana Rodrigues
Veridiana Rodrigues

1 July 2009 in Toxicon
Verified
Journal Article
Closed access
DLDAIANA LOPES
DAIANA LOPES
CBCristiani Baldo
Cristiani Baldo
COCarolina de Freitas Oliveira
Carolina de Freitas Oliveira
TATânia Machado de Alcântara
Tânia Machado de Alcântara
JOJaqueline D. Dias Oliveira
Jaqueline D. Dias Oliveira
VRVeridiana Rodrigues
Veridiana Rodrigues