Lars N. Jorgensen

Prof. Lars N. Jorgensen

orcid

Research Focus & Metrics

Academic Career Length

39Years (1988-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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20 March 2014 in Hernia
Verified
Journal Article
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MMMarc Miserez
Marc Miserez
EPE. Peeters
E. Peeters
TAT. Aufenacker
T. Aufenacker
JBJ. L. Bouillot
J. L. Bouillot
GCG. Campanelli
G. Campanelli
MSM. P. Simons
M. P. Simons

27 June 2019 in Surgical Endoscopy
Verified
Journal Article
Open access
PDF file
RBR. Bittner
R. Bittner
KBK. Bain
K. Bain
VBV. K. Bansal
V. K. Bansal
FBFrederik Berrevoet
Frederik Berrevoet
JBJ. Bingener-Casey
J. Bingener-Casey
QYQ. Yao
Q. Yao
In 2014, the International Endohernia Society (IEHS) published the first international “Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias.” Guidelines reflect the currently best available evidence in diagnostics and therapy and give recommendations to help surgeons to standardize their techniques and to improve their results. However, science is a dynamic field which is continuously developing. Therefore, guidelines require regular updates to keep pace with the evolving literature. Methods For the development of the original guidelines, all relevant literature published up to year 2012 was analyzed using the ranking of the Oxford Centre for Evidence-Based Medicine. For the present update, all of the previous authors were asked to evaluate the literature published during the recent years from 2012 to 2017 and revise their statements and recommendations given in the initial guidelines accordingly. In two Consensus Conferences (October 2017 Beijing, March 2018 Cologne), the updates were presented, discussed, and confirmed. To avoid redundancy, only new statements or recommendations are included in this paper. Therefore, for full understanding both of the guidelines, the original and the current, must be read. In addition, the new developments in repair of abdominal wall hernias like surgical techniques within the abdominal wall, release operations (transversus muscle release, component separation), Botox application, and robot-assisted repair methods were included. Results Due to an increase of the number of patients and further development of surgical techniques, repair of primary and secondary abdominal wall hernias attracts increasing interests of many surgeons. Whereas up to three decades ago hernia-related publications did not exceed 20 per year, currently this number is about 10-fold higher. Recent years are characterized by the advent of new techniques—minimal invasive techniques using robotics and laparoscopy, totally extraperitoneal repairs, novel myofascial release techniques for optimal closure of large defects, and Botox for relaxing the abdominal wall. Furthermore, a concomitant rectus diastasis was recognized as a significant risk factor for recurrence. Despite insufficient evidence with respect to these new techniques, it seemed to us necessary to include them in the update to stimulate surgeons to do research in these fields. Conclusion Guidelines are recommendations based on best available evidence intended to help the surgeon to improve the quality of his daily work. However, science is a continuously evolving process, and as such guidelines should be updated about every 3 years. For a comprehensive reference, however, it is suggested to read both the initial guidelines published in 2014 together with the update. Moreover, the presented update includes also techniques which were not known 3 years before.

14 October 2009 in JAMA
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Journal Article
Open access
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Christian S. MeyhoffChristian S. Meyhoff
Christian S. Meyhoff
JWJørn Wetterslev
Jørn Wetterslev
LJLars N. Jorgensen
Lars N. Jorgensen
SHSteen W. Henneberg
Steen W. Henneberg
CHClaus Kim Høgdall
Claus Kim Høgdall
FGfor the PROXI Trial Group
for the PROXI Trial Group
Surgical site infection is a common and serious complication following abdominal surgery.1 To prevent surgical site infection, it is essential to optimize perioperative conditions in the first hours following bacterial contamination.2 Tissue oxygen tension is often low in wounds and colorectal anastomoses, and this may reduce tissue healing via oxidative killing by neutrophils and also reduce induction of collagen formation, neovascularization, and epithelialization.3-7 Perioperative arterial and wound oxygen tension can be increased by a higher inspiratory oxygen fraction.7

1 November 2006 in Journal of Thrombosis and Haemostasis
Verified
Journal Article
Closed access
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MRM. S. Rasmussen
M. S. Rasmussen
LJLars N. Jorgensen
Lars N. Jorgensen
PWP. Wille‐Jørgensen
P. Wille‐Jørgensen
JNJ. D. Nielsen
J. D. Nielsen
AHA. Horn
A. Horn
BOB. Olsen
B. Olsen

1 February 2005 in Archives of Surgery
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Journal Article
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LSLars Tue Sørensen
Lars Tue Sørensen
UHUlla B. Hemmingsen
Ulla B. Hemmingsen
LKLene T. Kirkeby
Lene T. Kirkeby
FKFinn Kallehave
Finn Kallehave
LJLars N. Jorgensen
Lars N. Jorgensen
Research from JAMA Surgery — Smoking Is a Risk Factor for Incisional Hernia

1 May 2014 in Annals of Surgery
Verified
Journal Article
Closed access
PKPeter-Martin Krarup
Peter-Martin Krarup
ANAndreas Nordholm-Carstensen
Andreas Nordholm-Carstensen
LJLars N. Jorgensen
Lars N. Jorgensen
HHHenrik Harling
Henrik Harling
To investigate the impact of anastomotic leak (AL) on disease recurrence and long-term mortality in patients alive 120 days after curative resection for colonic cancer. There is no solid data as to whether AL after colonic cancer surgery increases the risk of disease recurrence. This was a nationwide cohort study of 9333 patients, prospectively registered in the database of the Danish Colorectal Cancer Group and merged with data from the Danish Pathology Registry and the National Patient Registry. Multivariable Cox regression analysis was used to adjust for confounding. The incidence of AL was 6.4%, 744 patients died within 120 days. Of the remaining 8589 patients, 861 (10.0%) developed local recurrence with no association to AL [adjusted hazard ratio (HR) = 0.78; 95% confidence interval (CI): 0.55-1.12; P = 0.184]. Distant recurrence developed in 1281 (14.9%) patients and more frequently after AL (adjusted HR = 1.42; 95% CI: 1.13-1.78; P = 0.003). AL was also associated with increased long-term mortality (adjusted HR = 1.20; 95% CI: 1.01-1.44; P = 0.042). In 2841 patients with stage III cancer, AL was associated with both decreased likelihood of receiving adjuvant chemotherapy (adjusted HR = 0.58; 95% CI: 0.45-0.74; P < 0.001) and a delay to initial administration (16 days; 95% CI: 12-20 days; P < 0.001). AL was significantly associated with increased rates of distant recurrence and long-term all-cause mortality. Cancelled or delayed administration of adjuvant chemotherapy may partly account for these findings.