Gang Zhou

Prof. Gang Zhou


Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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11 June 2018 in Journal of Nanobiotechnology
Verified
Journal Article
Open access
PDF file
XCXiao-Jie Chen
Xiao-Jie Chen
XZXue-Qiong Zhang
Xue-Qiong Zhang
QLQi Liu
Qi Liu
JZJing Zhang
Jing Zhang
GZGang Zhou
Gang Zhou
Oral cancer is a common and aggressive cancer with high morbidity, mortality, and recurrence rate globally. Early detection is of utmost importance for cancer prevention and disease management. Currently, tissue biopsy remains the gold standard for oral cancer diagnosis, but it is invasive, which may cause patient discomfort. The application of traditional noninvasive methods-such as vital staining, exfoliative cytology, and molecular imaging-is limited by insufficient sensitivity and specificity. Thus, there is an urgent need for exploring noninvasive, highly sensitive, and specific diagnostic techniques. Nano detection systems are known as new emerging noninvasive strategies that bring the detection sensitivity of biomarkers to nano-scale. Moreover, compared to current imaging contrast agents, nanoparticles are more biocompatible, easier to synthesize, and able to target specific surface molecules. Nanoparticles generate localized surface plasmon resonances at near-infrared wavelengths, providing higher image contrast and resolution. Therefore, using nano-based techniques can help clinicians to detect and better monitor diseases during different phases of oral malignancy. Here, we review the progress of nanotechnology-based methods in oral cancer detection and diagnosis.

1 June 2022 in International Journal of Oral Science
Verified
Journal Article
Open access
PDF file
XZXin Zeng
Xin Zeng
XJXin Jin
Xin Jin
LZLiang Zhong
Liang Zhong
GZGang Zhou
Gang Zhou
MZMing Zhong
Ming Zhong
QCQianming Chen
Qianming Chen
The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists. The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers, based on factors such as detailed clinical medical history inquiry, histopathological examination, and ulceration-related systemic diseases screening. Not only it can provide a standardized procedure of oral ulceration, but also it can improve the diagnostic efficiency, in order to avoid misdiagnosis and missed diagnosis.

1 June 2019 in Pathology - Research and Practice
Verified
Journal Article
Closed access
XCXiao-Jie Chen
Xiao-Jie Chen
YTYa-Qin Tan
Ya-Qin Tan
NZNa Zhang
Na Zhang
MHMing-Jing He
Ming-Jing He
GZGang Zhou
Gang Zhou

7 April 2020 in Nanomedicine
Verified
Journal Article
Closed access
XCXiao-Jie Chen
Xiao-Jie Chen
XZXue-Qiong Zhang
Xue-Qiong Zhang
MTMing-Xiu Tang
Ming-Xiu Tang
QLQi Liu
Qi Liu
GZGang Zhou
Gang Zhou
Aim: To develop nanomedicines for immuno-therapy of oral dysplasia and oral squamous cell carcinoma. Materials & methods: All-trans retinoic acid (ATRA)-poly(lactide-co-glycolide acid) (PLGA)-poly(... Graphical abstract

24 May 2020 in Cell & Bioscience
Verified
Journal Article
Open access
PDF file
QPQiao Peng
Qiao Peng
JYJing-Ya Yang
Jing-Ya Yang
GZGang Zhou
Gang Zhou
Exosomes are cell-derived membranous vesicles of endosomal origin secreted by all type of cells and present in various body fluids. Exosomes are enriched in peptides, lipids, and nucleic acids, emerging as vital modulators in intercellular communication. Exosomes are increasingly being evaluated as biomarkers for diagnosis and prognosis of diseases, because the constituents of exosomes could be reprogrammed depending on the states of diseases. These features also make exosomes a research hotspot in oral diseases in recent years. In this review, we outlined the characteristics of exosomes, focused on the differential expressions and altered biological functions of exosomes in oral diseases, including oral squamous cell carcinoma, oral leukoplakia, periodontitis, primary Sjögren’s syndrome, oral lichen planus, as well as hand foot and mouth disease. Besides, accumulated evidence documents that it is implementable to consider the natural nanostructured exosomes as a new strategy for disease treatment. Herein, we highlighted the therapeutic potential of exosomes in oral tissue regeneration, oncotherapy, wound healing, and their superiority as therapeutic drug delivery vehicles.

10 February 2022 in Journal of Ethnopharmacology
Verified
Journal Article
Closed access
XWXin Wang
Xin Wang
MHMing-Jing He
Ming-Jing He
XCXiao-Jie Chen
Xiao-Jie Chen
YBYu-Ting Bai
Yu-Ting Bai
GZGang Zhou
Gang Zhou