In this manuscript, distinct approaches were used in order to obtain the best electrical power estimation from photovoltaic systems located at different selected places in Mexico. Multiple Linear Regression (MLR) and Gradient Descent Optimization (GDO) were applied as statistical methods and they were compared against an Adaptive Neuro-Fuzzy Inference System (ANFIS) as an intelligent technique. The data gathered involved solar radiation, outside temperature, wind speed, daylight hour and photovoltaic power; collected from on-site real-time measurements at Mexico City and Hermosillo City, Sonora State. According to our results, all three methods achieved satisfactory performances, since low values were obtained for the convergence error. The GDO improved the MLR results, minimizing the overall error percentage value from 7.2% to 6.9% for Sonora and from 2.0% to 1.9% for Mexico City; nonetheless, ANFIS overcomes both statistical methods, achieving a 5.8% error percentage value for Sonora and 1.6% for Mexico City. The results demonstrated an improvement by applying intelligent systems against statistical techniques achieving a lesser mean average error.

Doxorubicin (Dox) is the most widely used chemotherapeutic agent and is considered a highly powerful and broad-spectrum for cancer treatment. However, its application is compromised by the cumulative side effect of dose-dependent cardiotoxicity. Because of this, targeted drug delivery systems (DDS) are currently being explored in an attempt to reduce Dox systemic side-effects. In this study, DDS targeting hepatocellular carcinoma (HCC) has been designed, specifically to the asialoglycoprotein receptor (ASGPR). Dox-loaded albumin-albumin/lactosylated (core-shell) nanoparticles (tBSA/BSALac NPs) with low (LC) and high (HC) crosslink using glutaraldehyde were synthesized. Nanoparticles presented spherical shapes with a size distribution of 257 ± 14 nm and 254 ± 14 nm, as well as an estimated surface charge of −28.0 ± 0.1 mV and −26.0 ± 0.2 mV, respectively. The encapsulation efficiency of Dox for the two types of nanoparticles was higher than 80%. The in vitro drug release results showed a sustained and controlled release profile. Additionally, the nanoparticles were revealed to be biocompatible with red blood cells (RBCs) and human liver cancer cells (HepG2 cells). In cytotoxicity assays, Dox-loaded nanoparticles decrease cell viability more efficiently than free Dox. Specific biorecognition assays confirmed the interaction between nanoparticles and HepG2 cells, especially with ASGPRs. Both types of nanoparticles may be possible DDS specifically targeting HCC, thus reducing side effects, mainly cardiotoxicity. Therefore, improving the quality of life from patients during chemotherapy.

Schiff bases are imine derivatives widely recognized for their structural versatility and ability to coordinate transition metals, giving rise to compounds with remarkable physicochemical and biological properties. Over the last decade, numerous studies have reported their diverse applications, ranging from antimicrobial, antioxidant, and anticancer activities to roles as catalysts, fluorescent sensors, and photovoltaic materials. While previous reviews have focused on specific aspects—such as biomedical activity, catalytic transformations, or luminescent sensing—there is still a lack of an integrative perspective that connects these different areas. In this review, we provide a comprehensive analysis of recent advances in Schiff bases and their metal complexes, emphasizing their multifunctionality at the interface of bioinorganic chemistry and materials science. We highlight how metal coordination enhances biological activity, how structural design expands the scope of asymmetric catalysis, how Schiff‐based fluorophores are emerging as versatile luminescent sensors, and how aromatic and metal‐Schiff derivatives contribute to the development of next‐generation photovoltaic devices. By offering this transversal vision, the article aims to bridge fragmented knowledge and outline future research directions to fully exploit the potential of Schiff bases in medicine, catalysis, sensing, and sustainable energy.

Two new glycine-Schiff base copper(II) complexes were synthesized. Single crystal X-ray diffraction (SCXRD) allowed us to establish the structure of both complexes in the solid state. The glycine-Schiff base copper(II) complex derived from 2′-hydroxy-5′-nitroacetophenone showed a mononuclear hydrated structure, in which the Schiff base acted as a tridentate ligand, and the glycine-Schiff base copper(II) complex derived from 2′-hydroxy-5′-methylacetophenone showed a less common tetranuclear anhydrous metallocyclic structure, in which the Schiff base acted as a tetradentate ligand. In both compounds, copper(II) had a tetracoordinated square planar geometry. The results of vibrational, electronic, and paramagnetic spectroscopies, as well as thermal analysis, were consistent with the crystal structures. Both complexes were evaluated as catalysts in the olefin cyclopropanation by carbene transference, and both led to very high diastereoselectivity (greater than 98%).

The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe₂PO and Fe₂PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe₂PO and Fe₂PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.

With the objective of studying the conformational and macrocyclic effects of selected metal chelates on their peroxidase activities, Cu²⁺ and Fe³⁺ complexes were synthesized with a macrocyclic derivative of ethylenediaminetetraacetic acid and o-phenylenediamine (abbreviated as edtaodH₂) and its new open-chain analogue (edtabzH₂). The Fe³⁺ complex of edtaodH₂ has a peroxidase-like activity, whereas the complex of edtabzH₂ does not. The X-ray study of the former shows the formation of a dimeric molecule {[Fe(edtaod)]₂O} in which each metal with an octahedral coordination is overposed over the macrocyclic cavity, as a result of rigid macrocyclic frame, to form an Fe–O–Fe bridge; the exposure of the central metal to the environment facilitates the capture of oxygen to drive the biomimetic activity. The peroxidase-inactive Fe³⁺ complex consists of a mononuclear complex ion [Fe(edtabz)(H₂O)]⁺, the metal ion of which is suited in a distorted pentagonal bipyramid to be protected from environmental oxygen. The copper(II) complexes, which have mononuclear structures with high thermodynamic stability compared with the iron(III) complexes, show no peroxidase activity. The steric effects play a fundamental role in the biomimetic activity.