Konstantinos Kostopanagiotou

Dr. Konstantinos Kostopanagiotou

orcid

Research Focus & Metrics

Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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10 March 2023 in Medicina
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Journal Article
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EBEstera Bakinowska
Estera Bakinowska
KKKonstantinos Kostopanagiotou
Konstantinos Kostopanagiotou
MWMałgorzata Wojtyś
Małgorzata Wojtyś
KKKajetan Kiełbowski
Kajetan Kiełbowski
KPKonrad Ptaszyński
Konrad Ptaszyński
PTPeriklis Tomos
Periklis Tomos
Human echinococcosis is a zoonotic infection caused by the larvae of the tapeworm species Echinococcus. The liver is the most common location for a primary echinococcosis. However, the parasite may bypass or spread from the liver to the lungs, causing primary or secondary pulmonary echinococcosis, respectively. Pulmonary echinococcosis is a clinically challenging condition in which anthelminthic regiments are important, but surgery has the central role in removing the cysts and preventing recurrences. Surgical treatment may involve cystotomy, enucleation, capitonnage, or atypical resections, which occasionally are in combination with hepatic procedures. The utilization of modern devices is greatly underdescribed in surgery for thoracic infections, even though these facilitate much of the work. Therefore, this article aims to describe pulmonary echinococcosis and the role of modern surgical devices in the treatment process. Furthermore, we report surgical treatment of three different cases of pulmonary echinococcosis. Surgeries of uncomplicated and ruptured hepatic or pulmonary cysts are described. Simple small pulmonary echinococcal lesions can be excised by endostaplers both for diagnostic and curative reasons. Larger cysts can be removed by energy devices unless large bronchial air leaks occur. Complicated cysts require treatment by more extensive techniques. Inexperienced surgeons should not abstain but should carefully decide preoperatively how to proceed.

1 January 2015 in Annals of Thoracic Medicine
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Journal Article
Open access
KKKonstantinos Kostopanagiotou
Konstantinos Kostopanagiotou
RGRobertS George
RobertS George
EKEmmanuel Kefaloyannis
Emmanuel Kefaloyannis
KPKostas Papagiannopoulos
Kostas Papagiannopoulos
Th bronchopleural fistula following lung resection. Their role in the treatment of BBF has never been described. In this paper we report the successful embolization using silicon spigots in two patients with BBF secondary to malignant disease, when all surgical options were exhausted....

9 August 2021 in Journal of Clinical Medicine
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AKAndreas Kostroglou
Andreas Kostroglou
Emmanouil Ioannis KapetanakisEmmanouil Ioannis Kapetanakis
Emmanouil Ioannis Kapetanakis
PMParaskevi Matsota
Paraskevi Matsota
PTPeriklis Tomos
Periklis Tomos
KKKonstantinos Kostopanagiotou
Konstantinos Kostopanagiotou
Tatiana SidiropoulouTatiana Sidiropoulou
Tatiana Sidiropoulou
Although pleuroscopy is considered a safe and well tolerated procedure with a low complication rate, it requires the administration of procedural sedation and analgesia. The purpose of this study was to assess the effects of dexmedetomidine administration on oxygenation and respiratory function in patients undergoing diagnostic or therapeutic pleuroscopy. Through a prospective, single center, cohort study, we studied 55 patients receiving either a dexmedetomidine intravenous infusion supplemented by midazolam/fentanyl (Group DEX + MZ/F) or a conventional sedation protocol with midazolam/fentanyl (Group MZ/F). Our primary outcome was the changes in lung gas exchange (PaO2/FiO2 ratio) obtained at baseline and at predetermined end points, while changes in respiratory mechanics (FEV1, FVC and the ratio FEV1/FVC) and PaCO2 levels, drug consumption, time to recover from sedation and adverse events were our secondary endpoints (NCT03597828). We found a lower postoperative decrease in FEV1 volumes in Group DEX + MZ/F compared to Group MZ/F (p = 0.039), while FVC, FEV1/FVC and gas exchange values did not differ between groups. We also found a significant reduction in midazolam (p < 0.001) and fentanyl consumption (p < 0.001), along with a more rapid recovery of alertness postprocedure in Group DEX + MZ/F compared to Group MZ/F (p = 0.003), while pain scores during the postoperative period, favored the Group DEX + MZ/F (p = 0.020). In conclusion, the use of intravenous dexmedetomidine during pleuroscopy is associated with a smaller decrease in FEV1, reduction of the consumption of supplementary sedatives and analgesics and quicker awakening of patients postoperatively, when compared to midazolam/fentanyl. Therefore, dexmedetomidine administration may provide clinically significant benefits in terms of lung mechanics and faster recovery of patients undergoing pleuroscopy.

6 November 2024 in Current Oncology
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MWMałgorzata Wojtyś
Małgorzata Wojtyś
KKKonstantinos Kostopanagiotou
Konstantinos Kostopanagiotou
DKDawid Kordykiewicz
Dawid Kordykiewicz
PSPatryk Skorka
Patryk Skorka
AGAlexandros Polykarpos Polykarpos Gkioulekas
Alexandros Polykarpos Polykarpos Gkioulekas
PTPeriklis Tomos
Periklis Tomos
Mediastinal yolk sac tumors (YST) constitute a highly malignant subtype of primary non-seminomatous germ cell tumors, which are often locally advanced and unresectable at diagnosis. Due to their rarity and aggressiveness, there is not yet a standard optimal treatment approach. A widely employed multimodal strategy involves neoadjuvant cisplatin-based combination chemotherapy followed by consolidation surgery. Tumor infiltration into the lungs and adjacent cardiovascular structures is common, such that surgical intervention typically requires extensive resections, performed either by sternotomy or thoracotomy. For this review, we extensively searched the PubMed and Embase medical databases, identifying articles describing surgical treatment of mediastinal yolk sac tumors. The current literature provides limited details regarding the utilized surgical procedures, leaving clinicians without comprehensive guidance about the demanding nature of these resections. Here, we present a narrative description of the range of current surgical procedures. By highlighting these techniques, we provide a comprehensive overview of the current surgical landscape, thereby helping clinicians understand the potential complexities and considerations involved in managing these rare and aggressive tumors.

7 November 2022 in Surgery Open Science
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Journal Article
Open access
KKKajetan Kiełbowski
Kajetan Kiełbowski
MWMałgorzata Wojtyś
Małgorzata Wojtyś
KKKonstantinos Kostopanagiotou
Konstantinos Kostopanagiotou
HJHenryk Janowski
Henryk Janowski
JWJanusz Zenon Wójcik
Janusz Zenon Wójcik
One of the most uncommon manifestations of perioperative Covid-19 infection is impaired wound healing. The aim of this study is to present previously unreported observation of thoracotomy and esophageal anastomosis dehiscence in the course of Covid-19 infection after uncomplicated thoracic surgeries. This is a single-center study describing unusual wound and anastomosis complications in COVID-19 patients after uncomplicated thoracic surgeries. Medical data was prospectively collected and retrospectively reviewed. All patients admitted to the hospital were symptom free and tested negative for COVID-19 infection preoperatively. Clinical courses were compared to a non-infected control group from historical data. The total of 14 patients were included. Study group involved 7 patients with major wound and anastomosis complications concurrent with COVID-19 infection. Control group was composed of 7 patients matched with the type of surgeries and treated before Coronavirus pandemic. Surgeries included lung transplantations, lung cancer surgeries and esophagectomies. The mean age of the study group was 65.7 years. Major wound and anastomosis complications occurred 13.6 days postoperatively while the mean time of Covid-19 detection was 21 days. The course of infection varied from mild to very severe which resulted in 3 deaths due to COVID-19 induced ARDS. The mean time of hospital stay was 40,9 days. There were no differences between both groups in baseline characteristics while hospitalization time was significantly longer in the study group. COVID-19 infection should be included in differential diagnosis in postoperative patients with major wound or anastomosis complications.

20 July 2024 in Medicina
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Journal Article
Open access
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MWMałgorzata Wojtyś
Małgorzata Wojtyś
DKDawid Kordykiewicz
Dawid Kordykiewicz
JWJanusz Zenon Wójcik
Janusz Zenon Wójcik
PTPeriklis Tomos
Periklis Tomos
KKKonstantinos Kostopanagiotou
Konstantinos Kostopanagiotou
Poland syndrome (PS) is a rare congenital musculoskeletal entity occurring in approximately 1 in 30,000 newborns that manifests with variable symbrachydactyly, ipsilateral costochondral deformities, an absence of pectoral muscles, and breast underdevelopment. These have potential impacts on social, somatic, and psychological functionality, often leading affected individuals to seek expert opinions on corrective surgery. Due to phenotypic variability, strict management guidelines are lacking, with treatment decisions often based on the specialist’s personal experience rather than published evidence. Comprehensive imaging with CT and MRI with 3D reconstruction is crucial for providing a descriptive assessment of musculoskeletal defects. Management is multidisciplinary, involving thoracic, plastic, and pediatric surgeons and hand surgery specialists, as well as psychologists and developmental growth specialists. Surgery should achieve both structural and cosmetic correction to reverse the psychological and social impact and achieve patient satisfaction. We aim to provide thoracic surgeons the essential answers for sharing with affected adult individuals during consultations focusing on chest surgical correction.