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This study aimed to explore whether there were differences in suicidal ideation at different time points among sexual minority men (SMM) within five years of HIV diagnosis, and to investigate the influence of time and psychosocial variables on suicidal ideation. This was a five-year follow-up study focusing on the suicidal ideation among HIV-positive SMM who were recruited when they were newly diagnosed with HIV. Suicidal ideation and psychosocial characteristics including depression, anxiety, HIV-related stress, and social support were assessed within one month, the first year, and the fifth year after HIV diagnosis. A total of 197 SMM newly diagnosed with HIV completed three-time point surveys in this study. The prevalence of suicidal ideation was 27.4%, 15.7%, and 23.9% at one month, the first year, and the fifth year after HIV diagnosis, respectively. The risk of suicidal ideation was lower in the first year than baseline, but there was no significant difference between the fifth year and baseline. Emotional stress and objective support independently predicted suicidal ideation and they had interactions with time. The suicidal ideation of SMM newly diagnosed with HIV decreased in the first year and then increased in the fifth year, not showing a sustained decline trend in a longer trajectory of HIV diagnosis. Stress management, especially long-term stress assessment and management with a focus on emotional stress should be incorporated into HIV health care in an appropriate manner. In addition, social support should also be continuously provided to this vulnerable population.
Rui Luo; Vincent M. B. Silenzio; Yunxiang Huang; Xi Chen; Dan Luo. The Changes and the Predictors of Suicidal Ideation Among HIV-positive Sexual Minority Men: A Five-year Longitudinal Study from China. AIDS and Behavior 2021, 1 -11.
AMA StyleRui Luo, Vincent M. B. Silenzio, Yunxiang Huang, Xi Chen, Dan Luo. The Changes and the Predictors of Suicidal Ideation Among HIV-positive Sexual Minority Men: A Five-year Longitudinal Study from China. AIDS and Behavior. 2021; ():1-11.
Chicago/Turabian StyleRui Luo; Vincent M. B. Silenzio; Yunxiang Huang; Xi Chen; Dan Luo. 2021. "The Changes and the Predictors of Suicidal Ideation Among HIV-positive Sexual Minority Men: A Five-year Longitudinal Study from China." AIDS and Behavior , no. : 1-11.
Associations between most single metals and children's intelligence quotient (IQ) scores have been evaluated in previous studies. However, associations between multi-metal exposures and children’s IQ scores have not been analyzed. To assess the joint effects of lead (Pb), manganese (Mn), antimony (Sb), tin (Sn) and titanium (Ti) co-exposure on children’s IQ scores. A prospective cohort study was conducted in Shimen and Huayuan, Hunan Province, China. Urine metals levels were measured by inductively coupled plasma mass spectrometry (ICP-MS) at baseline. Children’s IQ scores were repeatedly measured at baseline and follow-up following the method of Raven's Standard Progressive Matrices (SPM) and standardized as z scores. We fitted linear regression models and Bayesian kernel machine regression (BKMR) models to investigate the associations of metal levels with children’s IQ scores after adjusting for covariates. A total of 633 participants aged 7–10 years completed the survey. Urinary Pb (β = -0.028, P = 0.022) and urinary Ti (β = -0.0003, P = 0.001) were inversely associated with children’s IQ scores. The BKMR analyses revealed significant negative overall effects of the five metals on children’s IQ scores when all the metals were above their median levels, while significant positive associations were shown when all the metal concentrations were below their median levels. The model also showed negative trends of Sn and Ti on children’s IQ. Furthermore, Ti and Sn had a synergistic relationship, with a decline in IQ score when Sn exposure was relatively high. The urinary Sn concentration was significantly higher but the urinary Ti concentration was significantly lower in participants from the Shimen area than in those from the Huayuan area. Decreasing trends of the overall effects were observed in both the Shimen and Huayuan areas. Our findings revealed that multi-metal exposures caused a decline in children’s IQ scores according to traditional linear regression models and the BKMR model. Our results provide some evidence of the association between multi-metal exposure and children’s IQ. Meanwhile, interactions between multi-metal exposures on children's IQ should be given more attention.
Minxue Shen; Chengcheng Zhang; Xiping Yi; Jian Guo; Shuaishuai Xu; Zhijun Huang; Meian He; Xiang Chen; Dan Luo; Fei Yang. Association of multi-metals exposure with intelligence quotient score of children: A prospective cohort study. Environment International 2021, 155, 106692 .
AMA StyleMinxue Shen, Chengcheng Zhang, Xiping Yi, Jian Guo, Shuaishuai Xu, Zhijun Huang, Meian He, Xiang Chen, Dan Luo, Fei Yang. Association of multi-metals exposure with intelligence quotient score of children: A prospective cohort study. Environment International. 2021; 155 ():106692.
Chicago/Turabian StyleMinxue Shen; Chengcheng Zhang; Xiping Yi; Jian Guo; Shuaishuai Xu; Zhijun Huang; Meian He; Xiang Chen; Dan Luo; Fei Yang. 2021. "Association of multi-metals exposure with intelligence quotient score of children: A prospective cohort study." Environment International 155, no. : 106692.
Background Studies have shown that the outbreak of infectious diseases would result in mental health problems. Females are in greater risk for psychological problems than males. The present study investigated gender differences of depression and anxiety and explored associated factors during the COVID-19 epidemic among Chinese social media users. Methods We recruited 3088 participants through social media cross China. Participants completed sociodemographic and the COVID-19 epidemic related questions, the 2-item Patient Health Questionnaire (PHQ-2), and the 2-item Generalized Anxiety Disorder Scale (GAD-2), the Chinese version of the 10-item Connor-Davidson Resilience Scale. We applied Chi-square test and ANOVA for data description and linear regression analysis for exploring factors associated with depression and anxiety. Results Of 3063 participants eligible for analysis, the total prevalence of depression and anxiety was 14.14 and 13.25%. Females were experiencing more severe stress and anxiety symptoms, while males showed better resilience to stress. The severity of depression symptoms would decrease with the increase of age resilience, and it would increase if being unemployed, feeling less adapted, being more stressed. The severity of anxiety symptoms would decrease with higher education and better resilience, and it would increase if being female, spending over 60 min on COVID-19 related information, less adapted, and being more stressed. Conclusion The findings show the increased prevalence of depression and anxiety in Chinese population during the COVID-19 epidemic, and females are experiencing more severe anxiety symptoms than males. As social media is the current main resource of information related to COVID-19, interventions should be implemented to help users to limit the time they spend on social media and to get key information related to the epidemic from authoritative and authentic resource to avoid infodemic and prevent mental health problems.
Fengsu Hou; Fengying Bi; Rong Jiao; Dan Luo; Kangxing Song. Gender differences of depression and anxiety among social media users during the COVID-19 outbreak in China:a cross-sectional study. BMC Public Health 2020, 20, 1 -11.
AMA StyleFengsu Hou, Fengying Bi, Rong Jiao, Dan Luo, Kangxing Song. Gender differences of depression and anxiety among social media users during the COVID-19 outbreak in China:a cross-sectional study. BMC Public Health. 2020; 20 (1):1-11.
Chicago/Turabian StyleFengsu Hou; Fengying Bi; Rong Jiao; Dan Luo; Kangxing Song. 2020. "Gender differences of depression and anxiety among social media users during the COVID-19 outbreak in China:a cross-sectional study." BMC Public Health 20, no. 1: 1-11.
Metabolic syndrome is an important risk factor for cardiovascular disease, type 2 diabetes mellitus, and all-cause mortality. However, the relationship between napping and metabolic syndrome remains contradictory. The aim of this study was to evaluate the association between nap duration after lunch and prevalence of metabolic syndrome, and subgroup differences in the associations among a government employee population. A total of 5129 participants (mean age 39.4 years) were included in this study. Nap duration after lunch was self-reported, and metabolic syndrome was defined according to the Joint Interim Statement in 2009. Multivariate logistic regression models and adjusted restricted cubic spline functions were used to examine the association and dose-response relationship between nap duration after lunch and prevalence of metabolic syndrome. Of the participants, 17.3% had metabolic syndrome and 81.4% were habitual nappers. Adjusted odds ratio (OR) (95% confidence interval (CI)) of metabolic syndrome for longer nap duration (>90 min) per day was 1.77 (95% CI 1.09 to 2.89), compared with reference (~30 min). Results of stratification analyses indicated the association was found only among females (OR 3.02, 95% CI 1.38 to 6.57), participants without mood symptoms (OR 1.97, 95% CI 1.19 to 3.25), and those having longer night sleep duration (≥8 h) (OR 2.34, 95% CI 1.20 to 4.56). Longer nap duration was also associated with components of metabolic syndrome, including elevated waist circumference, elevated fasting plasma glucose, and elevated triglycerides. In conclusion, longer nap duration after lunch was associated with a higher prevalence of metabolic syndrome in females, people without mood symptoms, and people having longer night sleep duration.
Jun He; Feiyun Ouyang; Dan Qiu; Yanying Duan; Dan Luo; Shuiyuan Xiao. Association of Nap Duration after Lunch with Prevalence of Metabolic Syndrome in a Chinese Government Employee Population. International Journal of Environmental Research and Public Health 2020, 17, 4268 .
AMA StyleJun He, Feiyun Ouyang, Dan Qiu, Yanying Duan, Dan Luo, Shuiyuan Xiao. Association of Nap Duration after Lunch with Prevalence of Metabolic Syndrome in a Chinese Government Employee Population. International Journal of Environmental Research and Public Health. 2020; 17 (12):4268.
Chicago/Turabian StyleJun He; Feiyun Ouyang; Dan Qiu; Yanying Duan; Dan Luo; Shuiyuan Xiao. 2020. "Association of Nap Duration after Lunch with Prevalence of Metabolic Syndrome in a Chinese Government Employee Population." International Journal of Environmental Research and Public Health 17, no. 12: 4268.
This study aimed to determine the change in mental health (depression and anxiety) among HIV-positive gay and bisexual men (GBM) one year after diagnosis and the disparities in trajectories of mental health between them. The potential factors contributing to the disparities were also investigated. This was a one-year follow-up study focusing on the mental health of newly diagnosed HIV-positive individuals. Participants rated their depression, anxiety, stress, and social support levels at baseline and one year later. Information on the utilization of mental healthcare and the initiation of antiretroviral therapy (ART) after diagnosis was collected at one-year follow-up. A total of 171 and 87 HIV-positive gay and bisexual men, respectively, completed two-time points surveys in this study. The depressive and anxiety symptoms experienced by HIV-positive GBM improvement one year after diagnosis. These improvements tended to be smaller in gay participants. Other factors including mental health care utilization and ART status during the one-year follow-up period, changes in social stress scores and objective social support scores were also associated with the changes in depression and anxiety, and all these factors, except for change in objective support, were found to be statistically different between HIV-positive GBM. Special attention should be given to the mental health of HIV-positive gay men. Promoting HIV-positive gay men to assess to mental health services and ART may be important for these populations to improve mental health. Enhancing social support and reducing stress levels may also be necessary for the vulnerable HIV-positive sexual minority groups.
Rui Luo; Vincent M.B. Silenzio; Yunxiang Huang; Xi Chen; Dan Luo. The Disparities in Mental Health Between Gay and Bisexual Men Following Positive HIV Diagnosis in China: A One-Year Follow-Up Study. International Journal of Environmental Research and Public Health 2020, 17, 3414 .
AMA StyleRui Luo, Vincent M.B. Silenzio, Yunxiang Huang, Xi Chen, Dan Luo. The Disparities in Mental Health Between Gay and Bisexual Men Following Positive HIV Diagnosis in China: A One-Year Follow-Up Study. International Journal of Environmental Research and Public Health. 2020; 17 (10):3414.
Chicago/Turabian StyleRui Luo; Vincent M.B. Silenzio; Yunxiang Huang; Xi Chen; Dan Luo. 2020. "The Disparities in Mental Health Between Gay and Bisexual Men Following Positive HIV Diagnosis in China: A One-Year Follow-Up Study." International Journal of Environmental Research and Public Health 17, no. 10: 3414.
Evidence have consistently shown social support to be protective against suicidal ideation among people living with HIV (PLWH), but little is known how social support protects PLHW from suicidal ideation. We aimed to explore whether social support could reduce suicidal ideation by reducing HIV-related stress levels or depression among PLWH during the early post-diagnosis phase. A cross-sectional study of 557 newly diagnosed PLWH was conducted. Information on suicidal ideation, social support, HIV-related stress and depression was collected using a self-administered questionnaire. Generalized structural equation modeling (GSEM) analyses were performed to determine the mediating effect of HIV-related stress and depression on the relationship between social support and suicidal ideation. One-fourth of participants reported considering suicide after HIV diagnosis. Higher social support could prevent PLWH from suicidal ideation directly or indirectly via reducing the HIV-related stress levels. The mediating effect of depression, as well as the chain mediating effect of HIV-related stress and depression were not found. Enhancing social support and reducing HIV-related stress are important to prevent suicide among PLWH.
Fengying Bi; Dan Luo; Yunxiang Huang; Xi Chen; Dexing Zhang; Shuiyuan Xiao. The relationship between social support and suicidal ideation among newly diagnosed people living with HIV: the mediating role of HIV-related stress. Psychology, Health & Medicine 2020, 1 -11.
AMA StyleFengying Bi, Dan Luo, Yunxiang Huang, Xi Chen, Dexing Zhang, Shuiyuan Xiao. The relationship between social support and suicidal ideation among newly diagnosed people living with HIV: the mediating role of HIV-related stress. Psychology, Health & Medicine. 2020; ():1-11.
Chicago/Turabian StyleFengying Bi; Dan Luo; Yunxiang Huang; Xi Chen; Dexing Zhang; Shuiyuan Xiao. 2020. "The relationship between social support and suicidal ideation among newly diagnosed people living with HIV: the mediating role of HIV-related stress." Psychology, Health & Medicine , no. : 1-11.
About 83000 COVID-19 patients were confirmed in China up to May 2020. The effects of this public health crisis - and the varied efforts to contains its spread - have altered individuals’ “normal” daily functioning. This impact on social, psychological, and emotional well-being remain relatively unexplored, especially the ways in which Chinese men and women experience and respond to potential behavioral-related stressors. A cross-sectional study was conducted in late February 2020. Demographic characteristics and residential living conditions were measured along with psychological stress and behavior responses to the COVID-19 epidemic. 3088 questionnaires were received: 1749 females (56.6%) and 1339 males (43.4%). The mean level of stress, as measured by a visual analog scale, was 3.4 (SD=2.4) - but differed significantly by sex. Besides sex, factors positively associated with stress included: age (≤45 years), employment (unsteady income, unemployed), risk infection population (exposed to COVID-19, completed medical observation), difficulties encountered (diseases, work/study, financial, mental), behaviors(higher desire for COVID-19 knowledge, more time spent on the COVID-19). “Protective” factors included frequently contact with colleagues, calmness, and psychological resilience. Males and females also differed significantly in adapting to current living/working status, coping with heating, and psychological support service needs. Among Chinese, self-reported stress related to the COVID-19 epidemic were significantly related to sex, age, employment, resilience and coping styles. Future responses to such public health threats may wish to provide sex- and/or age-appropriate supports for psychological health and emotional well-being to those at greatest risk of experiencing stress.
Kangxing Song; Rui Xu; Terry D. Stratton; Voyko Kavcic; Dan Luo; Fengsu Hou; Fengying Bi; Rong Jiao; Shiyan Yan; Yang Jiang. Sex differences and Psychological Stress: Responses to the COVID-19 epidemic in China. 2020, 1 .
AMA StyleKangxing Song, Rui Xu, Terry D. Stratton, Voyko Kavcic, Dan Luo, Fengsu Hou, Fengying Bi, Rong Jiao, Shiyan Yan, Yang Jiang. Sex differences and Psychological Stress: Responses to the COVID-19 epidemic in China. . 2020; ():1.
Chicago/Turabian StyleKangxing Song; Rui Xu; Terry D. Stratton; Voyko Kavcic; Dan Luo; Fengsu Hou; Fengying Bi; Rong Jiao; Shiyan Yan; Yang Jiang. 2020. "Sex differences and Psychological Stress: Responses to the COVID-19 epidemic in China." , no. : 1.
Background A reasonable allocation of health resources is often characterized by equity and high efficiency. This study aims to evaluate the equity and efficiency of maternal and child health (MCH) resources allocation in Hunan Province, China. Methods Data related to MCH resources and services was obtained from the Hunan maternal and child health information reporting and management system. The Gini coefficient and data envelopment analysis (DEA) were employed to evaluate the equity and efficiency of MCH resources allocation, respectively. Results The MCH resources allocation in terms of demographic dimension were in a preferred equity status with the Gini values all less than 0.3, and the Gini values for each MCH resources’ allocation in terms of the geographical dimension ranged from 0.1298 to 0.4256, with the highest values in the number of midwives and medical equipment (≥ CNY 10,000), which exceeds 0.4, indicating an alert of inequity. More than 40% regions in Hunan were found to be relatively inefficient with decreased return to scale in the allocation of MCH resources, indicating those inefficient regions were using more inputs than needed to obtain the current output levels. Conclusions The equity of MCH resources by population size is superior by geographic area and the disproportionate distribution of the number of medical equipment (≥ CNY 10,000) and midwives between different regions was the main source of inequity. Policy-makers need to consider the geographical accessibility of health resources among different regions to ensure people in different regions could get access to available health services. More than 40% of regions in Hunan were found to be inefficient, with using more health resources than needed to produce the current amount of health services. Further investigations on factors affecting the efficiency of MCH resources allocation is still needed to guide regional health plans-making and resource allocation.
Minyuan Huang; Dan Luo; Zhanghua Wang; YongMei Cao; Hua Wang; Fengying Bi; Yunxiang Huang; Luxi Yi. Equity and efficiency of maternal and child health resources allocation in Hunan Province, China. BMC Health Services Research 2020, 20, 1 -10.
AMA StyleMinyuan Huang, Dan Luo, Zhanghua Wang, YongMei Cao, Hua Wang, Fengying Bi, Yunxiang Huang, Luxi Yi. Equity and efficiency of maternal and child health resources allocation in Hunan Province, China. BMC Health Services Research. 2020; 20 (1):1-10.
Chicago/Turabian StyleMinyuan Huang; Dan Luo; Zhanghua Wang; YongMei Cao; Hua Wang; Fengying Bi; Yunxiang Huang; Luxi Yi. 2020. "Equity and efficiency of maternal and child health resources allocation in Hunan Province, China." BMC Health Services Research 20, no. 1: 1-10.
This study explored the HIV-related stressors that people living with HIV (PLWH) commonly experience and express as stressful at the time of diagnosis and 1 year later. The factors associated with stress levels and whether social support would moderate the negative effects of stress on psychological health (depressive and anxiety symptoms) were also investigated. Newly diagnosed PLWH were consecutively recruited in this study. Participants rated their stress with the HIV/AIDS Stress Scale at baseline and 1 year later. Social support, depression, and anxiety were also self-reported at both time points. There were significant decreases in stress levels 1 year after diagnosis. Stressors regarding confidentiality, disclosure, emotional distress, fear of infecting others, and excessive attention to physical functions were the most problematic at baseline and 1-year follow-up. A younger age, married status, not living alone, less income, presence of HIV symptoms, and lack of social support were associated with higher levels of stress. No stress-buffering effect of social support on depressive and anxiety symptoms was found in this study. Interventions to reduce stress among PLWH should take into consideration the following priority stressors: confidentiality, discrimination/stigma, serostatus disclosure, distressing emotions, fear of infecting others, and excessive attention to physical functions. More attention should be paid to PLWH with younger age, not living alone, less income, presence of HIV symptoms, and lack of social support.
Yunxiang Huang; Dan Luo; Xi Chen; Dexing Zhang; Zhulin Huang; Shuiyuan Xiao. HIV-Related Stress Experienced by Newly Diagnosed People Living with HIV in China: A 1-Year Longitudinal Study. International Journal of Environmental Research and Public Health 2020, 17, 2681 .
AMA StyleYunxiang Huang, Dan Luo, Xi Chen, Dexing Zhang, Zhulin Huang, Shuiyuan Xiao. HIV-Related Stress Experienced by Newly Diagnosed People Living with HIV in China: A 1-Year Longitudinal Study. International Journal of Environmental Research and Public Health. 2020; 17 (8):2681.
Chicago/Turabian StyleYunxiang Huang; Dan Luo; Xi Chen; Dexing Zhang; Zhulin Huang; Shuiyuan Xiao. 2020. "HIV-Related Stress Experienced by Newly Diagnosed People Living with HIV in China: A 1-Year Longitudinal Study." International Journal of Environmental Research and Public Health 17, no. 8: 2681.
Psychosocial problems are common among people living with HIV (PLWH) and have been cross-sectionally associated with health-related quality of life (HRQoL). We evaluated the longitudinal relationship between psychosocial status and HRQoL among PLWH during the first year after diagnosis. A consecutive sample of newly diagnosed PLWH was recruited from Changsha Center for Disease Control and Prevention in Hunan Province, China. Assessments were conducted at baseline and 1 year later. The measures used in this study included the Medical Outcomes Study HIV Survey (MOS-HIV), the 9-item Patient Health Questionnaire (PHQ-9), the HIV/AIDS Stress Scale (SS-HIV) and the Social Support Rating Scale (SSRS). The trajectories of depression from baseline to 1-year follow-up were categorized into four groups: never (PHQ-9 < 10 at two time points), new-onset (PHQ-9 < 10 at baseline & PHQ-9 ≥ 10 at follow-up), recovered (PHQ-9 ≥ 10 at baseline & PHQ-9 < 10 at follow-up) and persistent depression (PHQ-9 ≥ 10 at two time points). In addition, the trajectories of stress and social support were classified by calculating the proportions of participants whose stress and social support scores changed between baseline and 1-year follow-up by more than 0.5 effect size in either direction. Generalized linear models were used to examine the potential role of baseline and changes in psychosocial status in predicting the HRQoL at 1 year, after adjusting for socio-demographic and clinical characteristics. A total of 410 participants completed both the baseline and 1-year follow-up surveys. Higher stress levels at baseline predicted a lower HRQoL at 1 year, while baseline depression status and social support did not predict 1-year HRQoL scores. Compared to those who were never depressed at both baseline and follow-up, participants who experienced new-onset or persistent depression had lower HRQoL at 1 year. Additionally, the 1-year HRQoL score of participants who recovered from depression by follow-up was comparable to that of participants who were never depressed. Moreover, participants who experienced increases in stress levels by follow-up had lower HRQoL scores at 1 year than those with decreases in stress levels. Changes in social support did not predict 1-year HRQoL scores in this study. Assessing psychosocial status regularly and implementing effective interventions targeted at psychosocial problems may be particularly important for PLWH to improve their HRQoL. Among PLWH, special attention should be given to those with new-onset or persistent depression and those with high stress levels at the time of diagnosis and increased stress levels 1 year after the new HIV diagnosis.
Yunxiang Huang; Dan Luo; Xi Chen; Dexing Zhang; Zhulin Huang; Shuiyuan Xiao. Role of psychosocial status in predicting health-related quality of life at 1-year follow-up among newly diagnosed people living with HIV. PLOS ONE 2019, 14, e0224322 .
AMA StyleYunxiang Huang, Dan Luo, Xi Chen, Dexing Zhang, Zhulin Huang, Shuiyuan Xiao. Role of psychosocial status in predicting health-related quality of life at 1-year follow-up among newly diagnosed people living with HIV. PLOS ONE. 2019; 14 (10):e0224322.
Chicago/Turabian StyleYunxiang Huang; Dan Luo; Xi Chen; Dexing Zhang; Zhulin Huang; Shuiyuan Xiao. 2019. "Role of psychosocial status in predicting health-related quality of life at 1-year follow-up among newly diagnosed people living with HIV." PLOS ONE 14, no. 10: e0224322.
Concern over mental health morbidity affecting people living with HIV is increasing worldwide. The objective of this study was to describe the longitudinal trajectories of depression and anxiety, and mental health service utilization among people newly diagnosed with HIV. This was an observational cohort study that enrolled people newly diagnosed with HIV consecutively and followed them for one year in Changsha, China. Socio-demographic, clinical and psychological data were collected at the baseline and at one-year follow-up. Participants were recruited between March 1, 2013 and September 30, 2014. The final follow-up was in September 30, 2015. Among 557 people newly diagnosed with HIV enrolled at the baseline, 410 (73.6%) completed the one-year follow-up survey (median (interquartile range) age at follow-up: 29 (25, 39) years; 376 men (91.7%)), and were included in the analysis. 39.3% and 30.2% of the 410 participants were screened with significant symptoms of depression and anxiety at baseline respectively. An overall drop in the prevalence of each condition was found at follow-up, however, 10.5% and 6.1% of participants were found to have persistent depression and anxiety. The results of mixed-effect models showed that bisexuality, homosexual transmission, other clinical symptoms (for example, not on antiretroviral therapy (ART)), non-disclosure, higher levels of HIV/AIDS-related stress, and lack of social support were associated with significant symptoms of depression and anxiety. One year after diagnosis, 8.3% had visited healthcare providers for emotional or psychological problems. Despite the obvious need people newly diagnosed with HIV in China rarely seek professional help. Integrating depression and anxiety screening and referral into HIV care settings is warranted.
Lu Niu; Dan Luo; Xi Chen; Min Wang; Wei Zhou; Dexing Zhang; Shuiyuan Xiao. Longitudinal trajectories of emotional problems and unmet mental health needs among people newly diagnosed with HIV in China. Journal of the International AIDS Society 2019, 22, e25332 .
AMA StyleLu Niu, Dan Luo, Xi Chen, Min Wang, Wei Zhou, Dexing Zhang, Shuiyuan Xiao. Longitudinal trajectories of emotional problems and unmet mental health needs among people newly diagnosed with HIV in China. Journal of the International AIDS Society. 2019; 22 (8):e25332.
Chicago/Turabian StyleLu Niu; Dan Luo; Xi Chen; Min Wang; Wei Zhou; Dexing Zhang; Shuiyuan Xiao. 2019. "Longitudinal trajectories of emotional problems and unmet mental health needs among people newly diagnosed with HIV in China." Journal of the International AIDS Society 22, no. 8: e25332.
Microcystin-LR is a cyclic heptapeptide hepatotoxin produced by harmful cyanobacteria. A panel of microRNAs containing miR-451a were found to be significantly changed in normal human liver cells HL7702 after exposure to microcystin-LR (MC-LR) in our previous study. However, the functions of miR-451a in hepatotoxicity induced by MC-LR remained unclear. The study aimed to investigate the impacts of miR-451a in HL7702 cells following treatment with 5 or 10 μM MC-LR. The comet assay indicated that MC-LR can influence Olive tail moment (OTM) in HL7702 cells. Furthermore, increase of miR-451a significantly repressed DNA damage and the protein expression level of γ-H2AX induced by MC-LR. Moreover, over-expression of miR-451a inhibited the expression level of p-AKT1 protein in cells following treatment by MC-LR. These results showed that miR-451a may protect from MC-LR-induced DNA damage by down-regulating the expression of p-AKT1, which provides new clues for the diagnosis and therapy policies for liver damage induced by MC-LR.
Lv Chen; Shu Yang; Cong Wen; Shuilin Zheng; Yue Yang; Xiangling Feng; Jihua Chen; Dan Luo; Ran Liu; Fei Yang. Regulation of Microcystin-LR-Induced DNA Damage by miR-451a in HL7702 Cells. Toxins 2019, 11, 164 .
AMA StyleLv Chen, Shu Yang, Cong Wen, Shuilin Zheng, Yue Yang, Xiangling Feng, Jihua Chen, Dan Luo, Ran Liu, Fei Yang. Regulation of Microcystin-LR-Induced DNA Damage by miR-451a in HL7702 Cells. Toxins. 2019; 11 (3):164.
Chicago/Turabian StyleLv Chen; Shu Yang; Cong Wen; Shuilin Zheng; Yue Yang; Xiangling Feng; Jihua Chen; Dan Luo; Ran Liu; Fei Yang. 2019. "Regulation of Microcystin-LR-Induced DNA Damage by miR-451a in HL7702 Cells." Toxins 11, no. 3: 164.
This study aimed to investigate changes in health-related quality of life (HRQoL) among people newly diagnosed with HIV and to identify factors associated with HRQoL. Newly diagnosed HIV-positive individuals were consecutively recruited and assessed at baseline and 1-year follow-up after diagnosis. HRQoL was measured through the physical health summary score (PHS) and mental health summary score (MHS) derived from the Medical Outcomes Study HIV Health Survey. Socio-demographic, clinical, and psychological information was also collected at both times. Generalized estimating equations were applied to explore factors associated with HRQoL in 1 year. A total of 410 participants were included. After 1 year, significant increases were observed for both the mean PHS score (53.5–55.0; p = 0.009) and the mean MHS score (44.2–49.0; p < 0.001). Older age (p = 0.024), rural household registration (p = 0.031), HIV-related symptoms (p < 0.001), and depression (p = 0.014) were negatively associated with PHS. Additionally, the negative association between stress and PHS increased over time (β = − 0.07 for the baseline; β = − 0.18 for the 12-month follow-up; p < 0.001). HIV-related symptoms, depression, lower social support, and higher levels of stress (all p < 0.001) were negatively associated with MHS. Additionally, the negative relationship between stress and MHS was stronger among participants who were asymptomatic (p = 0.015). A relatively lower HRQoL among HIV-infected people shortly after HIV diagnosis and an increase in HRQoL among people 1 year after HIV diagnosis were observed. Additional attention should be paid to individuals of older age, from rural areas, with HIV-related symptoms, with depression, with high levels of stress, and with a lack of social support.
Yunxiang Huang; Dan Luo; Xi Chen; Dexing Zhang; Min Wang; Yangyang Qiu; Ying Liu; Bihua Peng; Lu Niu; Shuiyuan Xiao. Changes and determinants of health-related quality of life among people newly diagnosed with HIV in China: a 1-year follow-up study. Human Genetics 2018, 28, 35 -46.
AMA StyleYunxiang Huang, Dan Luo, Xi Chen, Dexing Zhang, Min Wang, Yangyang Qiu, Ying Liu, Bihua Peng, Lu Niu, Shuiyuan Xiao. Changes and determinants of health-related quality of life among people newly diagnosed with HIV in China: a 1-year follow-up study. Human Genetics. 2018; 28 (1):35-46.
Chicago/Turabian StyleYunxiang Huang; Dan Luo; Xi Chen; Dexing Zhang; Min Wang; Yangyang Qiu; Ying Liu; Bihua Peng; Lu Niu; Shuiyuan Xiao. 2018. "Changes and determinants of health-related quality of life among people newly diagnosed with HIV in China: a 1-year follow-up study." Human Genetics 28, no. 1: 35-46.
Free antiretroviral therapy has been implemented in China since 2004, but adherence to antiretroviral therapy among people living with HIV is suboptimal. The effectiveness of antiretroviral therapy is subject to medication adherence, which decreases with prolonged treatment times. The aim of this study was to investigate medication adherence and related factors among people living with HIV with newly initiated antiretroviral therapy. This observational study was conducted in consecutive samples of people living with HIV who had newly initiated antiretroviral therapy. Participants were recruited between March 1, 2013, and August 31, 2014, from the local Center for Disease Control and Prevention and Infectious Disease hospital in a capital city in central China. A standard set of questionnaires was adopted, including the Community Programs for Clinical Research on AIDS Antiretroviral Medications and Self-Report Questionnaire (CPCRA), the Patient Health Questionnaire-9 (PHQ-9) and the 7-item Generalized Anxiety Disorder Scale (GAD-7). T-test, Chi square test and multivariate logistic regression analysis with backward stepwise were performed to explore factors that might influence medication adherence. Of the 207 participants, 85.5% of the participants (177/207) were categorized with good adherence, and 14.5% (30/207) with poor adherence. The multivariate logistic regression analyses showed that participants with positive depression (OR = 5.95, 95% CI: 2.34–15.11) and without disclosure of their HIV status to others (OR = 2.62, 95% CI: 1.06–6.50) were more susceptible to poor adherence. One-sixth of the participants reported suboptimal medication adherence within the first 6 months. Factors associated with poor adherence included non-disclosure of their HIV status, had positive depression. Tailored interventions, such as effective psychological coping strategies, should be implemented for people living with HIV with newly initiated antiretroviral therapy to improve their medication adherence.
Yang Yu; Dan Luo; Xi Chen; Zhulin Huang; Min Wang; Shuiyuan Xiao. Medication adherence to antiretroviral therapy among newly treated people living with HIV. BMC Public Health 2018, 18, 825 .
AMA StyleYang Yu, Dan Luo, Xi Chen, Zhulin Huang, Min Wang, Shuiyuan Xiao. Medication adherence to antiretroviral therapy among newly treated people living with HIV. BMC Public Health. 2018; 18 (1):825.
Chicago/Turabian StyleYang Yu; Dan Luo; Xi Chen; Zhulin Huang; Min Wang; Shuiyuan Xiao. 2018. "Medication adherence to antiretroviral therapy among newly treated people living with HIV." BMC Public Health 18, no. 1: 825.
Objective: The present study was designed to assess the quality of Chinese-language Internet-based information on HIV/AIDS. Methods: We entered the following search terms, in Chinese, into Baidu and Sogou: “HIV/AIDS”, “symptoms”, and “treatment”, and evaluated the first 50 hits of each query using the Minervation validation instrument (LIDA tool) and DISCERN instrument. Results: Of the 900 hits identified, 85 websites were included in this study. The overall score of the LIDA tool was 63.7%; the mean score of accessibility, usability, and reliability was 82.2%, 71.5%, and 27.3%, respectively. Of the top 15 sites according to the LIDA score, the mean DISCERN score was calculated at 43.1 (95% confidence intervals (CI) = 37.7–49.5). Noncommercial websites showed higher DISCERN scores than commercial websites; whereas commercial websites were more likely to be found in the first 20 links obtained from each search engine than the noncommercial websites. Conclusions: In general, the HIV/AIDS related Chinese-language websites have poor reliability, although their accessibility and usability are fair. In addition, the treatment information presented on Chinese-language websites is far from sufficient. There is an imperative need for professionals and specialized institutes to improve the comprehensiveness of web-based information related to HIV/AIDS.
Lu Niu; Dan Luo; Ying Liu; Shuiyuan Xiao. The Accessibility, Usability, and Reliability of Chinese Web-Based Information on HIV/AIDS. International Journal of Environmental Research and Public Health 2016, 13, 834 .
AMA StyleLu Niu, Dan Luo, Ying Liu, Shuiyuan Xiao. The Accessibility, Usability, and Reliability of Chinese Web-Based Information on HIV/AIDS. International Journal of Environmental Research and Public Health. 2016; 13 (8):834.
Chicago/Turabian StyleLu Niu; Dan Luo; Ying Liu; Shuiyuan Xiao. 2016. "The Accessibility, Usability, and Reliability of Chinese Web-Based Information on HIV/AIDS." International Journal of Environmental Research and Public Health 13, no. 8: 834.
Background: This study is one part of a five-year tobacco-control project in China, which aimed to gain insight into the smoking behavior, knowledge, and attitudes among medical teachers in China. Methods: In May 2010, a cross-sectional survey was conducted among medical teachers of Xiangya Medical School, Central South University, China. Results: A total number of 682 medical teachers completed the surveys. Latent class analysis indicated the sample of smoking patterns was best represented by three latent subgroups of smoking consumption severity levels. Most respondents were informed of smoking related knowledge, but lack of knowledge on smoking cessation. Most of them held a supportive attitude towards their responsibilities among tobacco control, as well as the social significance of smoking. However, both smoking related knowledge and attitude were not correlated with severity of smoking consumption among medical teachers. Conclusion: The smoking prevalence among medical teachers in China remains high. Programs on smoking cessation training are required. Future study should also develop targeted interventions for subgroups of smokers based on smoking consumption. Persistent and effective anti-tobacco efforts are needed to achieve the goals of creating smoke-free campuses and hospitals.
Lu Niu; Dan Luo; Vincent M.B. Silenzio; Shuiyuan Xiao; Yongquan Tian. Are Informing Knowledge and Supportive Attitude Enough for Tobacco Control? A Latent Class Analysis of Cigarette Smoking Patterns among Medical Teachers in China. International Journal of Environmental Research and Public Health 2015, 12, 12030 -12042.
AMA StyleLu Niu, Dan Luo, Vincent M.B. Silenzio, Shuiyuan Xiao, Yongquan Tian. Are Informing Knowledge and Supportive Attitude Enough for Tobacco Control? A Latent Class Analysis of Cigarette Smoking Patterns among Medical Teachers in China. International Journal of Environmental Research and Public Health. 2015; 12 (10):12030-12042.
Chicago/Turabian StyleLu Niu; Dan Luo; Vincent M.B. Silenzio; Shuiyuan Xiao; Yongquan Tian. 2015. "Are Informing Knowledge and Supportive Attitude Enough for Tobacco Control? A Latent Class Analysis of Cigarette Smoking Patterns among Medical Teachers in China." International Journal of Environmental Research and Public Health 12, no. 10: 12030-12042.