Visual inspection of the workplace and timely reminders of unsafe behaviors (e.g, not wearing a helmet) are particularly significant for avoiding injuries to workers on the construction site. Video surveillance systems generate large amounts of non-structure image data on site for this purpose; however, they require real-time recognition automation solutions based on computer vision. Although various deep-learning-based models have recently provided new ideas for identifying helmets in traffic monitoring, few solutions suitable for industry applications have been discussed due to the complex scenarios of construction sites. In this paper, a fast and robust network based on a mutilscale Swin Transformer is proposed for safety helmet detection (FRSHNet) at construction sites, which contains the following contributions. Firstly, MAE-NAS with the variant of MobileNetV3’s MobBlock as a basic block is applied to implement feature extraction. Simultaneously, a multiscale Swin Transformer module is utilized to obtain the spatial and contexture relationships in the multiscale features. Subsequently, in order to meet the scheme requirements of real-time helmet detection, efficient RepGFPN are adopted to integrate refined multiscale features to form a pyramid structure. Extensive experiments were conducted on the publicly available Pictor-v3 and SHWD datasets. The experimental results show that FRSHNet consistently provided a favorable performance, outperforming the existing state-of-the-art models.

The application of therapeutic peptides in clinical practice has significantly progressed in the past decades. However, immunogenicity remains an inevitable and crucial issue in the development of therapeutic peptides. The prediction of antigenic peptides presented by MHC class II is a critical approach to evaluating the immunogenicity of therapeutic peptides. With the continuous upgrade of algorithms and databases in recent years, the prediction accuracy has been significantly improved. This has made in silico evaluation an important component of immunogenicity assessment in therapeutic peptide development. In this review, we summarize the development of peptide-MHC-II binding prediction methods for antigenic peptides presented by MHC class II molecules and provide a systematic explanation of the most advanced ones, aiming to deepen our understanding of this field that requires particular attention.

Peptide-mediated protein-protein interactions (PPIs) play an important role in various biological processes. The development of peptide-based drugs to modulate PPIs has attracted increasing attention due to the advantages of high specificity and low toxicity. In the development of peptide-based drugs, one of the most important steps is to determine the interaction details between the peptide and the target protein. In addition to experimental methods, recently developed computational methods provide a cost-effective way for studying protein-peptide interactions. In this article, we carefully reviewed recently developed protein-peptide docking methods, which were classified into three groups: template-based docking, template-free docking, and hybrid method. Then, we presented available benchmarking sets and evaluation metrics for assessing protein-peptide docking performance. Furthermore, we discussed the use of molecular dynamics simulations, as well as deep learning approaches in protein-peptide complex prediction.