Natural polymer hydrogels are one of the best biomaterials for soft tissue repair because of their excellent biocompatibility, biodegradability and low immune rejection. However, they lack mechanical strength matching that of natural tissue and desired functionality (e.g., self-healing and 3D-printability). To solve these problems, we developed a host–guest supramolecule (HGSM) with three arms covalently crosslinked with a natural polymer to construct a novel hydrogel with non-covalent bonds integrated into a covalently crosslinked network. This unique structure enabled the hydrogel to exhibit improved mechanical properties and show both self-healing and 3D printing capabilities. The three-armed HGSM was first prepared via efficient non-covalent host–guest inclusion interactions between isocyanatoethyl acrylate-modified β-cyclodextrin (β-CD-AOI₂) and acryloylated tetra-ethylene glycol-modified adamantane (A-TEG-Ad). Subsequently, a host–guest supramolecular hydrogel (HGGelMA) was obtained through copolymerization between the arms of the HGSM and gelatin methacryloyl (GelMA) to form a covalently crosslinked network. The HGGelMA was robust, fatigue resistant, reproducible and rapidly self-healing. In the HGGelMA, the covalent crosslinking maintained its overall shape, whereas the weak reversible non-covalent host–guest interactions reinforced its mechanical properties and enabled it to rapidly self-heal upon fracturing. The reversible non-covalent interactions could be re-established upon breaking, so as to heal the hydrogel and dissipate energy to prevent catastrophic fracture propagation. Furthermore, the precursors of the HGGelMA were sufficiently viscous and could be rapidly photocrosslinked to produce a robust scaffold with an exquisite internal structure through 3D printing. The 3D-printed HGGelMA hydrogel scaffold was biocompatible, promoted cell adhesion and proliferation, and supported tissue in-growth. Our strategy of integrating a non-covalently linked HGSM into a covalently linked hydrogel network represents a new approach to the development of natural polymers into biocompatible hydrogels with improved strength as well as desired self-healing and 3D-printability.

Corporate digital transformation, as a key and representational component of the larger digital economy, plays a vital role in furthering both green technological innovation and the transition to a more sustainable economic model. This study collects panel data relating to firms listed on China’s A-share exchanges from 2009 to 2020 and employs textual analysis to estimate the extent of digital transformation within these organizations. It methodically examines the influence of this transformation on the volume and quality of green technological innovations. The findings reveal a substantial enhancement in both the volume and quality of green technological innovations as a result of corporate digital transformation, with a more noticeable improvement in innovation quality. This transition, driven by the mediating function of optimizing resource allocation, facilitates green technological innovation by enhancing human capital composition, curtailing information asymmetry, and augmenting investment in research and development (R&D). Heterogeneity research shows that the influence of digital transformation on green technological innovation is more pronounced in state-owned corporations, low-pollution corporations, and corporations situated in low-carbon pilot cities. Furthermore, this study discovers that the promotive influence of corporate digital transformation tends to diminish with the advancement of the corporation’s lifecycle, peaking during the growth phase. Finally, this study still has some limitations, such as its exclusive focus on Chinese corporations, the need for improvements in the measurement of digital transformation, and potential sample selection biases.

Background: The inflammatory myofibroblastic tumor (IMT) is an uncommon low-risk lesion with only a few cases described in the literature. Case Report: Here, we report a unique case of an IMT coexisting with breast cancer. Modified radical mastectomy was performed, followed by TAC chemotherapy (taxotere, adriamycin and cyclophosphamide). At the 2-year follow-up, the patient continues to be disease free. Conclusion: At the preoperative stage, definitive diagnoses of masses are extremely difficult; surgery is advised only after the diagnosis is confirmed by pathological examination.