Michele Vacca

Dr. Michele Vacca


Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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28 March 2024 in Cells
Verified
Journal Article
Open access
PDF file
MPMichele Prisciandaro
Michele Prisciandaro
ESEnrico Santinelli
Enrico Santinelli
VTValeria Tomarchio
Valeria Tomarchio
MTMaria Antonietta Tafuri
Maria Antonietta Tafuri
CBCecilia Bonchi
Cecilia Bonchi
MVMichele Vacca
Michele Vacca
Achieving successful hematopoietic stem cell transplantation (HSCT) relies on two fundamental pillars: effective mobilization and efficient collection through apheresis to attain the optimal graft dose. These cornerstones pave the way for enhanced patient outcomes. The primary challenges encountered by the clinical unit and collection facility within a transplant program encompass augmenting mobilization efficiency to optimize the harvest of target cell populations, implementing robust monitoring and predictive strategies for mobilization, streamlining the apheresis procedure to minimize collection duration while ensuring adequate yield, prioritizing patient comfort by reducing the overall collection time, guaranteeing the quality and purity of stem cell products to optimize graft function and transplant success, and facilitating seamless coordination between diverse entities involved in the HSCT process. In this review, we aim to address key questions and provide insights into the critical aspects of mobilizing and collecting hematopoietic stem cells for transplantation purposes.

29 January 2024 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
AMAntonio Moffa
Antonio Moffa
DNDomiziana Nardelli
Domiziana Nardelli
LGLucrezia Giorgi
Lucrezia Giorgi
SGSimone Di Giovanni
Simone Di Giovanni
LCLuca Carnuccio
Luca Carnuccio
Manuele CasaleManuele Casale
Manuele Casale
Background: With promising outcomes, platelet-rich plasma (PRP) has recently been suggested as a treatment for olfactory dysfunction (OD). Methods: Clinical studies utilizing PRP in OD caused by COVID-19, trauma, anesthetic exposure, viral infection, and chronic rhinosinusitis were included in a systematic review. Results: Ten clinical studies were qualitatively analyzed. Six of these studies used the PRP for OD caused by COVID-19, one on OD after functional endoscopic sinus surgery, and three on post-infectious or post-trauma OD. The population included 531 patients, ranging in age from 15 to 63. Conclusion: The use of PRP may be a risk-free and efficient therapeutic option with very encouraging outcomes. Indeed, it enhances olfactory perception in patients who not only exhibit COVID-19 infection aftereffects, but also in those who have lost their sense of smell due to trauma, rhinosinusitis, rhinitis, or even surgery. To evaluate the PRP’s therapeutic benefits in OD patients and to compare the efficacy of different therapeutic protocols with regard to treatment schedules, there is an urgent need for focused controlled trials.