Deep eutectic solvents (DESs) are increasingly being recognized as sustainable and promising solvents because of their unique properties: low melting point, low cost, and biocompatibility. Some DESs possess high viscosity, remarkable stability, and minimal toxicity, enhancing their appeal for diverse applications. Notably, they hold promise in biomass pretreatment, a crucial step in biomass conversion, although their potential in algal biomass carbohydrates extraction remains largely unexplored. Understanding the correlation between DESs’ properties and their behavior in carbohydrate extraction, alongside cellulose degradation mechanisms, remains a gap. This review provides an overview of the use of DESs in extracting carbohydrates from lignocellulosic and algal biomass, explores the factors that influence the behavior of DESs in carbohydrate extraction, and sheds light on the mechanism of cellulose degradation by DESs. Additionally, the review discusses potential future developments and applications of DESs, particularly extracting carbohydrates from algal biomass.

The water oxidation reaction plays an important role in clean energy conversion, utilization, and storage, but mimicking the oxygen-evolving complex of photosystem II for designing active and stable water oxidation catalysts (WOCs) is still an appealing challenge. Here, we innovatively engineered a molecular ruthenium WOC as a metal complex building unit to construct a series of three-dimensional metal covalent organic frameworks (3D MCOFs) for realizing efficient oxidation catalysis. The resultant MCOFs possessed rare 3D interlocking structures with inclined interpenetration of two-dimensional covalent rhombic nets, and the Ru sites were periodically arranged in the crystalline porous frameworks. Impressively, these MCOFs showed excellent performance towards water oxidation (the O₂ evolution rate is as high as 2830 nmol g⁻¹ s⁻¹) via the water nucleophilic attack pathway. Besides, the MCOFs were also reactive for oxidizing organic substrates. This work highlights the potential of MCOFs as a designable platform in integrating molecular catalysts for various applications.

Adhesion of monocytes to the vascular endothelium is crucial in atherosclerosis development. Connexins (Cxs) which form hemichannels or gap junctions, modulate monocyte-endothelium interaction. We previously found that rutaecarpine, an active ingredient of the Chinese herbal medicine Evodia, reversed the altered Cx expression induced by oxidized low-density lipoprotein (ox-LDL) in human umbilical vein endothelial cells, and consequently decreases the adhesive properties of endothelial cells to monocytes. This study further investigated the effect of rutaecarpine on Cx expression in monocytes exposed to ox-LDL. In cultured human monocytic cell line THP-1, ox-LDL rapidly reduced the level of atheroprotective Cx37 but enhanced that of atherogenic Cx43, thereby inhibiting adenosine triphosphate release through hemichannels. Pretreatment with rutaecarpine recovered the expression of Cx37 but inhibited the upregulation of Cx43 induced by ox-LDL, thereby improving adenosine triphosphate-dependent hemichannel activity and preventing monocyte adhesion. These effects of rutaecarpine were attenuated by capsazepine, an antagonist of transient receptor potential vanilloid subtype 1. The antiadhesive effects of rutaecarpine were also attenuated by hemichannel blocker 18α-GA. This study provides additional evidence that rutaecarpine can modulate Cx expression through transient receptor potential vanilloid subtype 1 activation in monocytes, which contributes to the antiadhesive properties of rutaecarpine.