The factors affecting information systems and technology have become a growing topic in many disciplines. This study focuses on factors affecting the adoption of digital dental technologies and dental informatics in dental practice. There are limited studies in the literature on factors that affect the adoption of digital dental technologies (DDT) and dental informatics (DI). Understanding the factors is important for the success of the adoption of technologies. Therefore, this study aims to fill that gap. This paper reviews peer-reviewed literature to analyze factors that affect the adoption of digital dental technologies (DDT) and dental informatics (DI) and critically examines an array of technology acceptance models to unveil the underlying determinants of DDT and DI adoption. Usability and practical considerations, work efficiency factors, socioeconomic and organizational aspects, aspects of the learning curve, and system design are the most important factors influencing the adoption of digital dental technologies and dental informatics. The study results identified the conceptual framework for the factors affecting the adoption of digital dentistry.