Background: Skin aging can be observed at various levels in the epidermis, dermis, and dermo‐epidermal junction. Reducing the cosmetic effects of skin aging in the facial region is a widespread demand due to common aesthetic concerns. Consequently, many injectable products on the market promise antiaging effects and cosmetic improvements. We aimed to evaluate the cosmetic efficacy of a high molecular weight sodium hyaluronate and amino acids mixture for the facial region using morphometric analysis.Methods: This study evaluates the morphometric effectiveness of an injectable mixture (high molecular weight sodium hyaluronate, glycine, L‐Proline, L‐leucine, L‐lysine HCL, L‐valine, and L‐alanine collagen active ingredient) on the mid‐face and jawline in women aged 30–55. We used morphological measurements and digital image data to assess changes and determine effectiveness. Various computational methods were applied simultaneously with statistical tests for validation.Results: The hydration assessment showed a significant increase on both sides of the face. A noticeable decrease was observed in gonion angle, bitragion breadth, bigonion breadth, and marionette wrinkle scale. These results suggest combining mechanical and chemical stimulation from the injection and its components (hyaluronic and amino acids) effectively enhances skin quality.Conclusions: The study indicates that the mechanical stimulation of the injection improves skin quality. Combining hyaluronic and amino acids (collagen, elastin, and pro‐synthetic) is a safe and effective alternative for antiaging treatments.

This study is among the first to systematically evaluate the indirect anatomical effects of hyaluronic acid injections on the glabellar and nasolabial regions. It focuses on changes in wrinkle severity and anatomical parameters to enhance safety and efficacy. In this study, we analyzed pre- and post-treatment photographs of 31 women with a mean age of 45.97 ± 7.10, who received hyaluronic acid treatment. The study was designed retrospectively. Photographs taken before the procedure and one month after treatment were obtained from the clinical archive. Digital anatomical measurements were performed on these images. The anatomical measurements focused on the glabella (including facial convexity, total facial convexity, and facial concavity) and the nasolabial regions (including nasolabial and nasolabial fold angles on both the right and left sides). Wrinkle Severity Rating Scale (WSRS) evaluations were also conducted for both the glabella and nasolabial folds. Evaluations were performed by analyzing photographs taken before, 4 weeks after, and 12 weeks after hyaluronic acid filler application. In the glabellar region, hyaluronic acid injections into the temporal and zygomatic areas significantly reduced wrinkles, especially 12 weeks post-treatment ( P = .004), indicating an indirect improvement in glabellar wrinkles. A positive correlation between age and wrinkle improvement was found ( r = 0.601, P = .000), suggesting more pronounced effects in older individuals. In the nasolabial region, significant reductions were observed in both the right ( P < .001) and left ( P < .001) nasolabial folds post-treatment, with age also correlating with improvement (right: r = 0.693, P = .000; left: r = 0.496, P = .005). The S300 and S500 formulations reduced wrinkles, with the S500 showing greater efficacy than the S300. The findings of our study suggest that hyaluronic acid fillers can indirectly reduce the depth of nasolabial folds, and this effect can be achieved particularly when applied using techniques that are suitable for anatomical and vascular structures. This approach may be considered a viable alternative in aesthetic procedures, as it has the potential to enhance treatment safety by reducing the risk of complications associated with direct interventions.

This study aims to investigate the indirect effects of calcium hydroxylapatite (CaHA) injections in the zygomatic and malar regions on the healing of nasolabial folds (NLFs). Given the anatomical complexity and proximity of the nasolabial area, selecting appropriate techniques for CaHA applications is crucial to prevent potential complications. The study is designed to contribute insights into the safety and efficacy of injections, aiming to enhance patient outcomes and minimize risks in aesthetic applications. This retrospective single-center study analyzed the effectiveness of CaHA injections in the zygomatic and malar regions for correcting NLFs in 51 female participants aged between 30 and 55. Images from clinical archives were used, taken before the application and 6 months after the application. The primary outcomes were evaluated using Gabor filter analysis, Global Aesthetic Improvement Scale, and Wrinkle Severity Rating Scale, complemented by morphometric measurements using Image J 1.52a software. Measurements before and 6 months after the application revealed significant improvements in NLF length: from 2.59 ± 0.64 cm to 2.24 ± 0.53 cm on the right side and from 2.76 ± 0.81 cm to 2.59 ± 0.61 cm on the left side. This corresponds to an improvement of 13.51 % and 6.16%, respectively. Evaluations using the Wrinkle Severity Rating Scale, Global Aesthetic Improvement Scale scores, and Gabor filter analysis also demonstrated positive NLF depth post-treatment changes. The results of our study indicate that CaHA injections in the zygomatic and malar regions lead to an indirect improvement in NLFs. Furthermore, our study provides standardized quantitative methods that can be used to assess the effectiveness of treatments in the nasolabial area. These analyses offer reliable tools for evaluating aesthetic procedures and provide valuable contributions to clinical practice.

Background: The skin around the glabella area is the region most affected by the underlying muscle activity during facial expressions and wrinkling. Although glabellar lines or wrinkles are commonly considered a cosmetic concern in the facial region, objective clinical assessment of this condition remains important. This study investi-gated the relationship between various patient characteristics, potentially reflecting lifestyle and physiological factors, and glabellar wrinkle patterns, which were categorized according to distinct muscle contraction types described in the literature. Materials and Methods: Data were collected from a total of 870 patients. One of the study's primary objectives was to explore the potential of using multiple patient-related variables in a machine learning-based prediction system while identifying the most influential characteristics associated with glabellar wrinkles. Multiple super-vised machine learning algorithms were employed to uncover potentially nonlinear associations and identify the most informative predictors, including Naïve Bayes, Random Forest, Logistic Regression, and K-Nearest Neigh-bors. Each model was tested across all possible feature subsets to evaluate their predictive performance. Results: The study aimed to demonstrate that a machine learning-based approach could be functional for the early prediction of glabellar wrinkles. The analysis revealed significant associations between patient characteris-tics, such as age, gender, education, marital status, and occupation, and distinct glabellar wrinkle patterns. Fur-thermore, the machine learning models demonstrated that these characteristics could be used to predict wrin-kle types with considerable performance. In the best scenario, separating the U-type pattern from others, an F1 score of 0.71 was achieved using K-Nearest Neighbors, supporting the potential for early identification and personalized intervention planning. Conclusions: The study confirmed that specific patient characteristics are strongly related to the formation of different glabellar wrinkle types. In addition, machine learning-based predictive systems showed promising performance, indicating their potential use in supporting clinicians with personalized cosmetic assessments and early intervention strategies.