This literature review examines the relationship between the urban environment and human health, focusing on five key parameters: air pollution, extreme temperatures, noise, green spaces, and urban mobility. A systematic review was conducted using indexed scientific databases (Scopus, Web of Science, and PubMed) and technical reports, following predefined search terms and exclusion criteria. A total of 131 publications were selected and analyzed. The study highlights the negative health effects of air pollution, heat, and noise—particularly on the respiratory, cardiovascular, nervous, and reproductive systems—especially in vulnerable populations including older adults, children, pregnant women, individuals with chronic illnesses, and those living in socioeconomically disadvantaged areas. In contrast, green spaces and sustainable mobility have shown beneficial impacts, including improvements in mental health, increased physical activity, and indirect benefits as they contribute to reducing air pollution, urban heat, and noise. Among all parameters, air pollution emerges as the most extensively studied and regulated, while significant research gaps persist in the fields of urban mobility and noise pollution. Furthermore, regulatory development remains limited across all parameters analyzed, highlighting the need for more comprehensive and consistent policy frameworks. Based on the evidence, three key urban strategies are proposed: renaturalizing cities, promoting sustainable mobility, and implementing data-driven management and educational tools. These actions are essential to create healthier, more resilient, and sustainable urban environments.

The rise in outdoor temperatures and heatwaves highlights the limitations of buildings in adapting to warming conditions, even in temperate climates. This paper analyses the indoor overheating of residential dwellings in Pamplona (a city in northern Spain, with a Cfb climate) using an urban-scale diagnostic methodology and presents different envelopes’ retrofitting scenarios as a strategy to reduce it. The results come from energy simulations conducted during an extremely warm summer in 2022, considering the microclimate effects. The residential typologies most vulnerable to overheating are those with only one orientation, built before the EPBD 2002, and located on top floors. These dwellings show a 23.7% mean of indoor overheating hours (IOH), representing approximately 870 h above the EN 16798-1:2019 adaptive threshold from May to September. Renovating building envelopes to meet current energy standards reduces the IOH by an average of 8.6% and up to 15.35% in the most vulnerable typologies. In the retrofitting scenario with green roof systems, indoor temperatures are up to 0.5 °C lower than when roofs are renovated with traditional systems. This study assists policy-makers in preventing the risk of overheating within cities and encourages them to promote nature-based solutions in order to adapt urban residential buildings and cities to warming conditions.