Longitudinal studies have shown inconsistent findings regarding the association between cognition, demographic characteristics, and clinical decline in relapsing-remitting multiple sclerosis (RRMS). Our objective was to further explore these relations, over time, while also considering age and sex. A total of 183 patients with RRMS were assessed at two time points, using a neuropsychological battery and the Expanded Disability Status Scale (EDSS). For the first assessment, participants were divided by age (<29, 30–39, 40–49, 50–60) and sex. Next, they were divided according to their participation in one of three interval assessment points: 2–3, 4–5, and 6–8 years. Cognitive function was not correlated with disease duration but was negatively correlated with EDSS score. Men under 29 and women under 39 showed negative correlations between cognitive and clinical impairment. Executive functions, attention, and information processing speed (IPS) showed cognitive decline between the first and second assessments. Furthermore, at the 4–5 year interval IPS predicted EDSS scores, while at the 6–8 year interval it was IPS and visuo-spatial ability. Therefore, relation between clinical status and cognition is not consistent across different age and sex groups. Additionally, cognitive deterioration is only partially evident longitudinally; however, IPS appears to be the most sensitive in predicting one’s future clinical condition.

The span paradigm is commonly used to assess working memory (WM), predominantly through the visual and auditory routes and less often through the tactile modality. The current study aimed to validate the “Tactual Span”, a new task developed to evaluate WM in the tactile modality. Participants were 140 healthy young adults, who performed the Tactual Span alongside span tasks in three additional modalities (auditory, visual, and visuospatial), as well as a selective attention task and a semantic verbal fluency task. The Tactual Span and other span tasks were found to correlate, while correlations with the selective attention and semantic fluency tasks were largely nonsignificant, indicating good construct validity. Cronbach’s alpha for both stages as well as skewness and kurtosis were also adequate. An exploratory factor analysis for the forward stage showed that the Tactual Span and Visuospatial Span were loaded on one factor, whereas the Auditory and Visual Spans were loaded on another factor. In the backward stage, all span tasks were loaded on a single factor. The findings provide an initial indication that the Tactual Span task is a feasible and valid tool for assessing WM in the tactile modality.

Traumatic spinal cord injury (tSCI) has implications in many areas, including cognitive functioning. Findings regarding cognitive problems in people with SCI are inconsistent, presumably due to mul...

Background: Working memory (WM) involves temporarily storing and manipulating information. Research on the impact of aging on WM has shown inconsistent results regarding the decline in visual and verbal WM, with a lack of studies on tactile WM. This study aimed to assess the effects of aging on WM across verbal, visuospatial, and tactile modalities using span tasks of forward (storage) and backward (manipulation) stages. Methods: A total of 130 participants, divided into four age groups of 20–29, 60–69, 70–79, and 80–89, completed the Digit, Visuospatial, and Tactual Spans. Performance was analyzed using a 3 (Task) × 4 (Group) × 2 (Stage) mixed design repeated measures ANOVA. Results: The analysis revealed significant main effects for modality (p < 0.001, η_p² = 0.15), age (p < 0.001, η_p² = 0.48), and stage (p < 0.001, η_p² = 0.30). Digit Span outperformed the other modalities, while Tactual Span showed the worst performance. Additionally, task performance declined with age, and the forward stage was superior to the backward stage. Interaction effects indicated that Digit Span was less affected by aging compared to the Visuospatial and Tactual Spans (p = 0.004, η_p² = 0.07). Post hoc analyses further revealed that the Digit Span consistently outperformed the other modalities in both stages, with more pronounced differences observed in the forward stage. Conclusions: Verbal WM is more resilient to aging compared to the other modalities while tactile WM declines with age in a manner similar to verbal and visuospatial WM, suggesting a modality-specific impact of aging on WM.