Microbial contamination of chronic wounds complicates their treatment. Traditional knowledge systems and the diversity of indigenous medicinal plants create a haven for traditional medicine practices in South Africa (SA). This systematic review aims to present a comprehensive ethnobotanical report of traditional medicines used in the documented empirical wound healing studies in SA. Google Scholar, PubMed, Medline EBSCOhost, Science Direct, and Scopus were sourced using the keywords/terminologies “South Africa”, “medicinal plants”, “traditional medicine” “indigenous”, “skin”, “wound”, “ethnobotany”, “survey”, “interview”, and “treatment” in different combinations. Relevant and unpublished records were retrieved from the Global Electronic Thesis Database. The searching process identified 32,419 records, of which 4005 studies were screened. Following the removal of 1795 duplicates, the remaining 2210 sources were screened by title and abstract, and 133 full-text reports were accessed and evaluated. Plants traditionally used for wound-healing purposes comprised 222 species belonging to 71 families, namely Asteraceae (predominantly the Helichrysum species), Asphodelaceae, Fabaceae, Solanaceae, and Euphorbiaceae. Plant organs used for medicinal remedies included leaves, roots, and bark prepared as poultices, infusions, decoctions, gel/ointments/lotions, and pastes. This review provides a valuable reference for future phytochemical and pharmacological studies and highlights the need for further ethnobotanical research to treat wounds in SA.