Nelleke Gertrude Langerak

Dr. Nelleke Gertrude Langerak

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Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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24 September 2013 in Developmental Medicine & Child Neurology
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Journal Article
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SGSebastian Grunt
Sebastian Grunt
AFAnthony Graham Fieggen
Anthony Graham Fieggen
JVJeroen Vermeulen
Jeroen Vermeulen
JBJules G Becher
Jules G Becher
NLNelleke Gertrude Langerak
Nelleke Gertrude Langerak

1 March 2008 in Journal of neurosurgery. Pediatrics
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Journal Article
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NLNelleke Gertrude Langerak
Nelleke Gertrude Langerak
RLRobert P. Lamberts
Robert P. Lamberts
AFAnthony Graham Fieggen
Anthony Graham Fieggen
JPJonathan C. Peter
Jonathan C. Peter
LMLize Van Der Merwe
Lize Van Der Merwe
CVChristopher Vaughan
Christopher Vaughan
Object: Selective dorsal rhizotomy (SDR) has been widely performed for the reduction of spasticity in patients with cerebral palsy during the past 2 decades. The objective of this study was to determine whether the surgery has yielded long-term functional benefits for these patients. Methods: The authors present results from a prospective 20-year follow-up study of locomotor function in 13 patients who underwent an SDR in 1985. For comparison, we also present gait data for 48 age-matched healthy controls (12 at each of 4 time points). Patients were studied preoperatively and then at 1, 3, 10, and 20 years after surgery. Study participants were recorded in the sagittal plane while walking using a digital video camera, and 6 standard gait parameters were measured. Results: In this group of patients 20 years after surgery, knee range of motion (ROM) was on average 12° greater than preoperative values (p < 0.001). Hip ROM before surgery was no different from that in the healthy control group. This parameter increased markedly immediately after surgery (p < 0.001) but had returned to normal after 20 years. The knee and hip midrange values—a measure of the degree of “collapse” due to muscle weakness after surgery—had returned to preoperative levels after 20 years, although they were respectively 11 and 8° greater than those in healthy controls. Both temporal-distance parameters (dimensionless cadence and dimensionless step length) were significantly greater at 20 years than preoperative values (cadence, p = 0.003; step length, p = 0.02), leading to improved walking speed. Conclusions: Twenty years after undergoing SDR, our patients showed improved locomotor function compared with their preoperative status.

1 November 2003 in Experimental Brain Research
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CVChristopher Vaughan
Christopher Vaughan
NLNelleke Gertrude Langerak
Nelleke Gertrude Langerak
MOMark J. O'MAlley
Mark J. O'MAlley

18 October 2016 in PLOS ONE
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Journal Article
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RLRobert P. Lamberts
Robert P. Lamberts
MBMarlette Burger
Marlette Burger
JTJacques du Toit
Jacques du Toit
NLNelleke Gertrude Langerak
Nelleke Gertrude Langerak
Three-dimensional gait analysis (3DGA) is commonly used to assess the effect of orthopedic single-event multilevel surgery (SEMLS) in children with spastic cerebral palsy (CP). The purpose of this systematic review is to provide an overview of different orthopedic SEMLS interventions and their effects on 3DGA parameters in children with spastic CP. A comprehensive literature search within six databases revealed 648 records, from which 89 articles were selected for the full-text review and 24 articles (50 studies) included for systematic review. The Oxford Centre for Evidence-Based Medicine Scale and the Methodological Index for Non-Randomized Studies (MINORS) were used to appraise and determine the quality of the studies. Except for one level II study, all studies were graded as level III according to the Oxford Centre for Evidence-Based Medicine Scale. The MINORS score for comparative studies (n = 6) was on average 15.7/24, while non-comparative studies (n = 18) scored on average 9.8/16. Nineteen kinematic and temporal-distance gait parameters were selected, and a majority of studies reported improvements after SEMLS interventions. The largest improvements were seen in knee range of motion, knee flexion at initial contact and minimal knee flexion in stance phase, ankle dorsiflexion at initial contact, maximum dorsiflexion in stance and in swing phase, hip rotation and foot progression angles. However, changes in 3DGA parameters varied based on the focus of the SEMLS intervention. The current article provides a novel overview of a variety of SEMLS interventions within different SEMLS focus areas and the post-operative changes in 3DGA parameters. This overview will assist clinicians and researchers as a potential theoretical framework to further improve SEMLS techniques within different SEMLS focus groups. In addition, it can also be used as a tool to enhance communication with parents, although the results of the studies can’t be generalised and a holistic approach is needed when considering SEMLS in a child with spastic CP.

1 February 2012 in Gait & Posture
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Journal Article
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NLNelleke Gertrude Langerak
Nelleke Gertrude Langerak
NTNicholas Tam
Nicholas Tam
CVChristopher Vaughan
Christopher Vaughan
AFAnthony Graham Fieggen
Anthony Graham Fieggen
MSMichael H. Schwartz
Michael H. Schwartz

20 November 2018 in Neurotherapeutics
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JEJohannes M. Nicolaas Enslin
Johannes M. Nicolaas Enslin
NLNelleke Gertrude Langerak
Nelleke Gertrude Langerak
AFAnthony Graham Fieggen
Anthony Graham Fieggen