In recent years, the digital economy has shown great potential in regard to in driving social production and development. In the context of the construction of digital villages, the deep integration of the digital economy and agricultural development has injected new vitality into improving the quality and efficiency of agricultural production, becoming an important way to promote sustainable agricultural development. Based on the panel data of 31 provinces in China from 2012 to 2021, the study utilizes the entropy method to measure the level of the digital economy and the high-quality development of agriculture. Additionally, this study explores the impact and mechanism of the digital economy on the high-quality development of agriculture by the fixed effect, mediation effect, and the spatial spillover models. In summary, the digital economy can significantly drive the high-quality development of agriculture, which is still valid after considering endogeneity and robustness. Mechanistically, the rationalization of industrial structure is an important path for the digital economy in regard to driving the high-quality development of agriculture. Regionally, the dividends of the digital economy for high-quality agricultural development in the central and western regions are greater than those in the eastern region. Spatially, the digital economy has a spatial spillover effect on the high-quality development of agriculture. Moreover, it can promote the synergistic development of adjoining regions. Therefore, policy recommendations are made in terms of strengthening rural infrastructure, emphasizing the development of regional shortcomings, and strengthening internal with external regional linkages.