Background: Peripheral arterial disease (PAD) causes significant morbidity today. Atherosclerosis is evident in the pathophysiological process in most patients, so PAD has similar risk factors as coronary artery disease. Platelet-Hemoglobin ratio (PHR) has been proven to predict mortality in atherosclerotic heart disease. We aimed to determine the relationship between PHR and below-knee amputation. Methods: The study is a single-center retrospective study. Platelet count/hemoglobin amount formula was used for PHR. Only PAD patients with below-knee critical extremity ischemia and unsuitable for revascularization were included in the study. Results: 235 patients were included in the study retrospectively. The mean age was 65.7 ± 9.9 years and 175(74.5%) of them were male. In the amputated group, white blood cell, neutrophil, platelet, creatinine, glucose, and PHR were higher (p = .031, p = .045, p = .011, p = .048 p = .018, p = .004, respectively). Only hemoglobin values were lower (p = .003). Multivariable regression analysis showed; age, albumin and PHR were determined as independent risk factors for amputation (Age; OR (95%CI): (1.094(1.040–1.152), p = .001) (Albumin; OR (95% CI): 1.950(1.623–1.799), p = .001) (PHR; OR (95% CI): 1.872(1.246–2.812), p = .003). Receiver operating characteristics analysis performed to determine the optimal cut-off value of PHR for amputation, the optimal value was found 2.08 (65.8% sensitivity, 67.5% specificity, p < .001). Conclusions: PHR was a good predictor for BKA. Using the PHR, it may be possible to identify high-risk patients for amputation.

Left atrial (LA) and left atrial appendage (LAA) remodeling are critical indicators of adverse cardiovascular outcomes linked to various risk factors. This study aims to investigate the correlation between CHA2DS2-VASc and left atrial measurements in patients with sinus rhythm. The retrospective, single-center study included 250 patients who underwent coronary computed tomography angiography (CCTA) imaging at a state hospital in Turkey. LA dimensions, volumes, LAA types, and LAA orifice area and volume were assessed using CCTA images. Additionally, we evaluated CHA₂DS₂-VASc scores and cardiovascular risk factors. This present study indicated that patients with low CHA₂DS₂-VASc scores had smaller appendage orifice area (270.69±84.72 vs. 300.97±97.65 mm², p=0.01), LA long diameter (60.73±6.83 vs. 64.53±7.66 mm, p<0.001), LA short diameter (40.32±5.88 vs. 43.02±6.54 mm, p=0.001), and LA volume (101.55±34.14 vs. 114.34±32.58 mm³, p=0.003). There was a significant relationship between patient age and all LA and LAA measurements, including LAA volume (r=0.204, p<0.001), LAA orifice area (r=0.342, p<0.001), LA long diameter (r=0.329, p<0.001), LA short diameter (r=0.257, p<0.001), and LA volume (r=0.231, p<0.001). Cardiovascular risk factors and CHA₂DS₂-VASc scores are valuable markers for assessing atrial cardiomyopathy and left atrial appendage (LAA) remodeling, and they may aid in predicting stroke risk.