The two-phase ejector is a simple and compact pressure boosting device and widely used in ejector steam-generator water feeding systems and core emergency cooling systems. The direct contact condensation of water and steam is the key process of a two-phase ejector. Usually, the high-temperature and high-pressure steam will inevitably induce non-condensable gases. The existence of non-condensable gases will reduce the condensation heat transfer rate between steam and water, and harm the equipment. This study carried out 3D numerical simulations of a two-phase ejector based on an inhomogeneous multiphase model. The steam inlet pressure and the non-condensable gas mass fraction rang in 0.6–2.9 MPa and 1–10%, respectively. The heat and mass transfer characteristics were analyzed under different conditions. The results show that the heat transfer coefficient and plume penetration length increased with the steam inlet pressure. Non-condensable gas prevents direct contact condensation between the steam and water. The non-condensable gas mass fraction rises from 1% to 10%, the heat transfer between steam and water deteriorates, and leads to a lower heat transfer coefficient.