The origin of highly permeable flow paths in carbonate-siliciclastic rocks, such as large-aperture fractures in aquifers in the Eastern Bohemian Cretaceous Basin (EBCB), is poorly understood. The karst potential was assessed from the rock carbonate content and the degree of disintegration after leaching in HCl. Surprisingly, dissolution of calcite in EBCB usually did not lead to rock disintegration until calcite > 78%. Instead, porosity increased significantly. High-porosity rock is held together by microns-thick secondary silica cement with a foam-like structure and considerable tensile strength. Three types of conduits occur in the EBCB: (i) bedding-parallel conduits associated with calcite-rich layers, (ii) subvertical fracture swarm conduits that develop on damaged zones of fracture swarms, and (iii) conduits formed by dissolution of calcite veins by groundwater flow. These are ghost-rock karst features where calcite is leached from the rock in the first phase and the residue is washed out by conduits under steep hydraulic gradients in the second phase. Very similar features have been described in Minnesota and Wisconsin, USA. Research has shown that fractures with sharp-edged walls that give the impression of an extensional tectonics origin may actually be ghost-rock karst features in which dissolution and piping have played an important role in their enlargement.