Microbial co-infections is becoming a global issue in the health care system, leading to an increase in mortality and morbidity rate. The overuse of antibiotics has led to the development of antimicrobial resistance (AMR), which is increasing, which then limits the currently used antibiotic. Hybrid molecules and metal complexes have sparked interest in the medical field for their therapeutic properties. In my research, we synthesize, characterize, and in-vitro biological evaluate compounds with effective antimicrobial potency against microbial co-infections associated with COVID-19.