A multidisciplinary approach embedded with sustainability represents a pathway to design strategies applicable in different cultural contexts. Considering the emissions attributed to building processes, the design of conservation measures is evolving to create high performance both in terms of healthiness and safety. On this, heritage buildings in earthquake-prone cities proved their vulnerability during the recent seismic events. However, the most important aspect of restoration interventions is that the design process must respect the architectural peculiarities of the building. In this regard, the contribution presents the reuse of a heritage building, currently disused, in the novel role of University of Perugia’s plaster cast gallery, in line with the aims declared by the University with the adoption of the “Action Plan for University Sustainability 2021–2023”. Such architecture is part of Palazzo Murena, University of Perugia headquarters, a former monastery designed by Luigi Vanvitelli and completed in 1762 by Carlo Murena. A historical-iconographical investigation, together with a survey, revealed the building origin: a pre-existing architecture, anciently a hospice, included by Vanvitelli in their project. The purpose was the masonries’ reinforcement conceiving, at once, a flexible space according to the adaptive architecture principle: give to buildings configurations new, whole or in part, from the original ones in response to emerging threats. An integrated project was designed to restore the building in order to realize a contemporary museum in which full-height exhibition spaces alternate with the pre-existing ones. In this way, the new Gypso|TechA showcases the academic plasters, actually without a seat matching their cultural value, and through a peculiar layout encodes the collection’s message in a site-specific cognitive process.

This research concerns the analysis of the evolution of the landscape of Lake Trasimeno, in the Umbria region (Italy). The case study is marked by an inconsistent settlement pattern. Nevertheless, it retains wide glimpses of unspoilt territory, still tied to its original values. The same landscape transformations offer a series of opportunities for recomposition. These require representative instruments capable of interpreting and guiding the valorisation of the rich heritage, all this also considering the strong tourism value of the area under study. From a methodological point of view, the contribution is structured in three main phases: a first phase of studying the tourism dynamics in the area; a second phase of mapping the identity and evolutionary characteristics of the area; a third phase of conception and development of three project proposals aimed at enhancing the identity characteristics of the place and at favouring its usability with a view to sustainable tourism. The restitution and interpretation of the analysis and mapping phases (albeit partial, because they are limited to only a part of the lake’s coastline) become fundamental for identifying sustainable project strategies, as they are integrated with the social, cultural and economic characteristics of the area.